Screening Unit

Chemical Biology

Graphical representation of compound properties in 3D to compare libraries. Red dots mark the ChemBioNet collection, yellow dots a fragment library of FMP and violet dots the NIH diversity set.
Live cell imaging with YFP coupled PKC.

Specific Features of Small Molecules used for Biology

Compounds which interfere with biological functions provide unique application features:

  • temporally:  recovery of function, timelines
  • dosage:       analysis of threshold levels
  • locally:        light inducible release of caged compounds
  • multiple:      application of modulator combinations

Efficient and systematic usage of small molecules as probes for exploring biological systems requires the set up of:

  • well designed compound libraries
  • automation for high throughput screening
  • chemistry for modification and optimization of hits
  • a well designed set of pharmacological profiling routines
  • tools for automated data documentation, analysis and communication

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Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)