RESEARCH GROUPS

Scientific Coordinator: Thomas Jentsch

A thorough knowledge of the molecular mechanisms that govern cellular life is essential in understanding how drugs work and identifying suitable new targets for pharmaceutical intervention. The genetic modification of mice is a powerful tool for clarifying the physiological and pathological roles of individual protein targets.

We perform basic research on the physiology and cell biology of ion channels and transporters, pre- and postsynaptic membrane proteins including synaptic vesicles, G-protein coupled receptors, exo-endocytic trafficking and the permeation properties of epithelia. To investigate these processes, we employ a broad arsenal of techniques, encompassing biochemistry, molecular and cellular biology, biophysics and imaging (light and electron microscopy), and the generation and analysis of transgenic mouse models.

Department Physiology and Pathology of Ion Transport  (Thomas J. Jentsch)

We study ion transport across cellular membranes using techniques of biophysics, cell and molecular biology, and genetically modified mouse models. This work has provided insights into cellular phenotypes including impaired endocytosis and lysosomal storage, and pathologoies such as deafness, epilepsy, kidney stones, etc.

 

Department Molecular Pharmacology and Cell Biology (Volker Haucke)

Membrane dynamics within the endocytic and endosomal system play crucial roles in cell physiology and membrane homeostasis, cell signaling and development, as well as in the functioning of the nervous system. Research in the laboratory is centered on the visualization and manipulation of the endocytic machinery and of endosomal membrane organization using a combination of biochemical, genetic, chemical, and optical imaging approaches with a particular focus on the nervous system.


Junior Research Group: Molecular Neuroscience and Biophysics (Andrew Plested)

Our interest is the glutamate-gated ion channel receptors of excitatory synapses. These receptors underlie essential functions in the brain, including learning and memory. We use electrophysiology to examine receptor kinetics in cell membranes. We combine this approach with molecular and structural biology to determine the shape and composition of receptor complexes.

 

 

Junior Research Group: Membrane Traffic and Cell Motility (Tanja Maritzen)

Our group studies the function of adaptor proteins in endocytic sorting and endosomal membrane traffic using cell biological methods as well as mouse genetics. We are especially interested in understanding the coordinated interplay between membrane transport and cytoskeletal dynamics and its role in regulating cellular motility. 

 

 

Junior Research Group: Proteostasis in Aging and Disease (Janine Kirstein)

The focus of our group is the analysis of the fold and function of proteins in a metazoan organism. We aim to uncover the complex mechanisms of the proteostasis network that is comprised of molecular chaperones and proteolytic machines, its strategies to cope with protein aggregates and its changes during development and with the progression of aging.

 

 

Junior Research Group / Liaison Group-Neuroscience: Behavioural Neurodynamics (Alexey Ponomarenko/Tatiana Korotkova)

We study molecular determinants of population neuronal activity. To establish the contribution of specific membrane conductancies and network pathways to the generation of network oscillations in vivo we apply parallel unitary recording techniques in freely behaving rodents and optogenetics. We further aim to  reveal and decode neural dynamics of genetically-defined hypothalamic circuits that coordinate multiple vital functions.

 

 

 

Emmy Noether Junior Group / Liaison Group-Neuroscience: Molecular and Theoretical Neuroscience (Alexander Walter)

Brain function relies on the communication between neurons via fast chemical transmission across synaptic contacts. Using electrophysiology and live-cell-imaging in combination with genetic and theoretical approaches our group wishes to identify the molecular principles of this incredibly well organized and highly complex process.

 


Protein-Trafficking (Ralf Schülein)

The Schülein group looks at the mechanisms that regulate the specific cell surface densities of G-protein coupled receptors (GPCRs), the main target molecules for drugs. We use a combination of molecular biology, biochemical and imaging methods as well as automated microscopy to identify new substances that influence GPCR trafficking.

 

Molecular Cell Physiology (Ingolf E. Blasig)

Our focus is the investigation of basic mechanisms in the establishment, maintenance and regulation of tight junction (TJ) structures which form cell-cell contacts. We use molecular and cell biology techniques, proteomic analyses and pharmacological approaches.

 

 

Core Facility: Cellular Imaging (Burkhard Wiesner)

Our group addresses questions of biological and pharmacological importance using the full repertoire of light microscopy techniques (confocal laser scanning microscopy, two-photon excitation, uncaging processes, FCS, FRAP, FRET, FLIM, cellular uptake of peptides, colocalisation studies, intracellular ion concentrations, protein translations studies, etc. in conjunction with the electron microscopic and electrophysiological techniques.

  

Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)
info(at)fmp-berlin.de