Molecular Cell Physiology (Ingolf E. Blasig)

The group focuses on the elucidation of structure, function, and manipulation of cell-cell contacts. The major objective is to explore tight junctions (TJ) in barrier-forming endothelial and epithelial cells under normal and pathological conditions to disclose neuropathophysiological mechanisms that underlie stroke, lesional epilepsy, and other conditions with the aim of finding better therapies. In addition, the development of new strategies specifically modulating the blood-brain barrier (BBB) may lead to improved drug delivery. The tightness of the BBB is mainly determined by transmembranal proteins which constantly seal the intercellular cleft. Special interest is directed towards the oligomerisation, scaffolding, and regulation of TJ proteins. The investigations are based on state-of-the-art technologies for molecular and cell biology, proteomic analyses and pharmacological approaches.

 

 

Projects


  • Peptide-mediated transient modulation of tight junctions

Leibniz-Institut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)
info(at)fmp-berlin.de