Contact

Prof. Dr. Volker Haucke

phone +49 30 94793 100
haucke(at)fmp-berlin.de

 

 

 

 

 

 

 

 

 

 

Department Molecular Pharmacology and Cell Biology (Volker Haucke)

Welcome to the Volker Haucke department!

The focus of research in the Haucke laboratory is the dissection of the molecular mechanisms of endocytosis and endolysosomal membrane dynamics and its role in cell signaling and neurotransmission. The laboratory uses a wide range of technologies that include biochemical and molecular biological approaches in vitro, chemical biology and screening technology, super-resolution and electron microscopy as well as genetic manipulations at the organismic level in vivo. The overarching goal of these studies is to provide a mechanistic understanding of exo-endocytosis and endolysosomal function and its regulation by proteins and lipids and to use this know-how to develop novel strategies for acute chemical and pharmacological interference.

Video presentation of the lab's research focus: Volker Haucke explaining endosomal recycling

Recent highlights of research

• Membrane retrieval at synapses occurs in part by clathrin-independent endocytosis, while clathrin and its major endocytic adaptor AP-2 regenerate synaptic vesicles from internal endosome-like vacuoles in addition to their action at the plasma membrane (Kononenko et al., Neuron 2014 link to pubmed abstract).

 • Endocytic adaptors (e.g. AP180) limit diffusional spread of newly exocytosed synaptic vesicle proteins (Gimber et al., Nat. Commun. 2015 link to pubmed abstract) and chaperone their sorting to recycling vesicle membranes (Koo et al., Neuron 2015 link to pubmed abstract link to video abstract); Kononenko et al., Proc. Natl. Acad. Sci. USA 2013 link to pubmed abstract; Diril et al., Dev. Cell 2006 link to pubmed abstract) to maintain neurotransmission in vivo.

• Identification of dGIT/ GIT1, a protein mutated in attention deficit hyperactivity syndrome (ADHS), as the first molecular link between the active zone cytomatrix for exocytosis and the endocytic machinery, thereby coupling neurotransmitter release to synaptic vesicle reformation (Podufall et al., Cell Reports 2014 link to pubmed abstract; Haucke et al., Nat Rev Neurosci. 2011 link to pubmed abstract).

• Discovery of phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) synthesized by phosphatidylinositol-3-kinase C2α as a novel key lipid that spatiotemporally controls endocytosis (Posor et al., Nature 2013 link to pubmed abstract)

• Development of the first small molecule inhibitors of clathrin function (von Kleist et al., Cell 2011 link to pubmed abstract)

• Discovery of a mechanism for phosphoinositide conversion at endosomes to enable exit from the endosomal system, suggesting that defective phosphoinositide conversion at endosomes underlies X-linked centronuclear myopathy (Ketel et al., Nature 2016 link to pubmed abstract).

Head

Prof. Dr. Volker Haucke

CV Volker Haucke

 

 

The Department also hosts the research group of

Prof. Dr. Michael Krauß
Small GTPases in Membrane Traffic


The Krauß lab is interested in elucidating roles of GTPases, in particular of septins, in membrane traffic and signaling, and for the maintenance of organelle integrity.

Read more about the Krauß Lab here!

Leibniz-Institut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)
info(at)fmp-berlin.de