AG Andrew Plested

Leibniz-Institut für Molekulare Pharmakologie &
Cluster of Excellence NeuroCure, Charité Universitätsmedizin

Robert-Rössle-Str. 10
13125 Berlin

Tel.: +49 (0) 30 9406-3071
                      -3011/5 (Lab.)

Fax: +49 (0) 30 9406-2960

plested [at]

Molecular Neuroscience and Biophysics (Andrew Plested)

In the Plested lab, we are interested in ion channel receptors. These receptors are found at synapses between nerve cells, and also at the junction between nerve and muscle. The activation of these complex macromolecular machines is triggered by neurotransmitters in a fraction of a second. Our objective is to understand the relationship between the molecular structure of a given receptor (its shape) and its activity (what it does).

We are members of the NeuroCure Cluster of Excellence, and the Leibniz-Institut für Molekulare Pharmakologie (FMP). Our laboratories are located in the Timoféeff-Ressovsky Haus (also called the Genomhaus or just plain Haus 87) at the Campus Berlin Buch. If you would like to contact us, please write to the email address on the right.

Latest News

17.02.17 Mechanism of partial agonism in AMPA-type glutamate receptors

Our paper on the relationship between partial agonists, conformational space and AMPA receptor activation is now online at Nature Communications. PDB entry is here. Congratulations to Hector, Clarissa and Miriam!

15.10.16 Sebastian Opfermann has joined us to do his PhD, studying glutamate receptors at the single channel level as part of our ERC funded project GluActive. Welcome Sebastian!

04.10.16 October seems to be Spanish month in the Plested lab. Alberto Gonzalez is visiting us from Tenerife, and Boris Bouazza is doing his first rotation of the Medical Neurosciences doctoral programme. Benvenidos a Berlín! 

20.08.16 Single Channel Recording of Ligand-Gated Ion Channels

A topic introduction and protocol for single channel recording of glycine receptors are now available as part of the Ion Channels collection at Cold Spring Harbor Lab Protocols. These articles are based on the lectures and practical course held every year at CSHL. Thanks to Jelena for help with the protocol!

16.06.16 Structural rearrangement of the intracellular domains during AMPA receptor activation

Mila's paper describing patch-clamp fluorometry of AMPARs is online at PNAS Early Edition. This work was a collaboration with Anders Kristensen's lab in Copenhagen. Congratulations to all!

Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)