Contact

Dr. Gerd Krause

phone +49 30 94793 228
fax +49 30 94 793 230
gkrause(at)fmp-berlin.de

Structural Bioinformatics and Protein Design
(Gerd Krause)

Research

The group investigates in silico and experimental sequence-structure-function relationships of membrane proteins and interaction partners. Investigated systems include G-protein coupled receptors (GPCRs), transporters and tight junction proteins. In this context one strength is the development of bioinformatic tools that support the analysis of evolutionary and functionally relevant mutations. Furthermore, dedicated databases provide access to structure-function analysis of GPCRs (www.ssfa-gphr.de, www.ssfa-7tmr.de/p2y12) and include a toolkit to generate new GPCR models (www.ssfa-7tmr.de/ssfe).  The protein models guide experimental mutagenis of the respective protein. The main aims are:  i) rational discovery of molecular mechanisms and sites for protein-protein and protein-ligand interactions;  ii) pinpointing spatially interacting residues at the target protein by predicting functional sensitive residues that are subsequently evaluated experimentally, such as by site-directed mutagenesis or peptide mapping and iii) derive new molecules (small compounds or proteins) as counterparts for potential pharmacological intervention.

News

Anna Piontek (nee Veshnyakova) was successful in publishing the shared first authorship paper
Neuhaus W* , Piontek A*  et al., 2018

"Reversible opening of the blood-brain barrier by claudin-5-binding variants of Clostridium perfingens enterotoxin`s clauding binding domain"
in the high standing journal Biomaterials.              18.01.2018   accepted


Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)
info(at)fmp-berlin.de

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