Solution NMR (Peter Schmieder)


  • Yang, Y., Linke, M., von Haimberger, T., Matute, R., González, L., Schmieder, P., Heyne, K. (2014). Active and silent chromophore isoforms for phytochrome Pr photoisomerization: An alternative evolutionary strategy to optimize photoreaction quantum yields. Struct. Dyn. 1, 014701.   DOI: 10.1063/1.4865233


  • Dorn, M., Jurk, M., Wartenberg, A., Hahn, A. & Schmieder, P. (2013). LOV takes a pick: thermodynamic and structural aspects of the Flavin-LOV-Interaction of the blue-light sensitive Photoreceptor YtvA from Bacillus subtilis. PLoS ONE 8, e81268. DOI: 10.1371/journal.pone.0081268

  • Fiebig, J., Weidauer, S., Qiu, L.-Y., Bauer, M., Schmieder, P., Beerbaum, M., Zhang, J.-L., Oschkinat, H., Sebald, W. & Mueller, T. (2013). The Clip-Segment of the von Willebrand Domain 1 of the BMP Modulator Protein Crossveinless 2 Is Preformed. Molecules 18, 11658-11682. DOI: 10.3390/molecules181011658

  • Schäfer, G., Milic, J., Eldahshan, A., Gotz, F., Zuhlke, K., Schillinger, C., Kreuchwig, A., Elkins, J. M., Abdul Azeez, K. R., Oder, A., Moutty, M. C., Masada, N., Beerbaum, M., Schlegel, B., Niquet, S., Schmieder, P., Krause, G., von Kries, J. P., Cooper, D. M., Knapp, S., Rademann, J., Rosenthal, W. & Klussmann, E. (2013). Highly Functionalized Terpyridines as Competitive Inhibitors of AKAP-PKA Interactions. Angew Chem Int Ed Engl 52, 12187-12191. DOI: 10.1002/anie.201304686

  • Hack, V., Reuter, C., Opitz, R., Schmieder, P., Beyermann, M., Neudörfl, J.-M., Kühne, R. & Schmalz, H.-G. (2013). Efficient α-Helix Induction in a Linear Peptide Chain by N-Capping with a Bridged-tricyclic Diproline Analogue. Angew Chem Int Ed Engl 52, 9539-9543. DOI: 10.1002/anie.201302014

  • Beerbaum, M., Ballaschk, M., Erdmann, N., Schnick, C., Diehl, A., Uchanska-Ziegler, B., Ziegler, A. & Schmieder, P. (2013). NMR spectroscopy reveals unexpected structural variation at the protein–protein interface in MHC class I molecules. J Biomol NMR 57, 167-178. DOI: 10.1007/s10858-013-9777-z

  • Schmieder, P., Nitschke, F., Steup, M., Mallow, K. & Specker, E. (2013). Determination of glucan phosphorylation using heteronuclear 1H,13C double and 1H,13C,31P triple-resonance NMR spectra. Magn Reson Chem 51, 655-661. DOI: 10.1002/mrc.3996

  • Nitschke, F., Wang, P., Schmieder, P., Girard, J.-M., Awrey, Donald E., Wang, T., Israelian, J., Zhao, X., Turnbull, J., Heydenreich, M., Kleinpeter, E., Steup, M. & Minassian, Berge A. (2013). Hyperphosphorylation of Glucosyl C6 Carbons and Altered Structure of Glycogen in the Neurodegenerative Epilepsy Lafora Disease. Cell Metabolism 17, 756-767. DOI: 10.1016/j.cmet.2013.04.006

  • Uchanska-Ziegler, B., Ziegler, A. & Schmieder, P. (2013). Structural and dynamic features of HLA-B27 subtypes. Curr Opin Rheumatol 25, 411-418. DOI: 10.1097/BOR.0b013e32836203ab

  • Jurk, M., Schramm, P. & Schmieder, P. (2013). The blue-light receptor YtvA from Bacillus subtilis is permanently incorporated into the stressosome independent of the illumination state. Biochem Biophys Res Commun 432, 499-503. DOI: 10.1016/j.bbrc.2013.02.025

  • Naue, N., Beerbaum, M., Bogutzki, A., Schmieder, P. & Curth, U. (2013). The helicase-binding domain of Escherichia coli DnaG primase interacts with the highly conserved C-terminal region of single-stranded DNA-binding protein. Nucleic Acids Res 41, 4507-4517. DOI: 10.1093/nar/gkt107

  • Elgabarty, H., Schmieder, P. & Sebastiani, D. (2013). Unraveling the existence of dynamic water channels in light-harvesting proteins: alpha-C-phycocyanobilin in vitro. Chem Sci 4, 755-763. DOI: 10.1039/c2sc21145a

  • Hee, C.-S., Beerbaum, M., Loll, B., Ballaschk, M., Schmieder, P., Uchanska-Ziegler, B. & Ziegler, A. (2013). Dynamics of free versus complexed β2-microglobulin and the evolution of interfaces in MHC class I molecules. Immunogenetics 65, 157-172. DOI: 10.1007/s00251-012-0667-4


  • Yang, Y., Linke, M., von Haimberger, T., Hahn, J., Matute, R., González, L., Schmieder, P. & Heyne, K. (2012). Real-Time Tracking of Phytochrome’s Orientational Changes During Pr Photoisomerization. J Am Chem Soc 134, 1408-1411. DOI: 10.1021/ja209413d

  • Dorn, M., Jurk, M. & Schmieder, P. (2012). Blue news update: BODIPY-GTP binds to the blue-light receptor YtvA while GTP does not. PLoS ONE 7, e29201. DOI: 10.1371/journal.pone.0029201


  • Hoppmann, C., Schmieder, P., Heinrich, N. & Beyermann, M. (2011). Photoswitchable click amino acids: light control of conformation and bioactivity. Chembiochem 12, 2555-2559. DOI: 10.1002/cbic.201100578

  • Jurk, M., Dorn, M. & Schmieder, P. (2011). Blue flickers of hope: secondary structure, dynamics, and putative dimerization interface of the blue-light receptor YtvA from Bacillus subtilis. Biochemistry 50, 8163-8171. DOI: 10.1021/bi200782j

  • Röben, M. & Schmieder, P. (2011). Assignment of phycocyanobilin in HMPT using triple resonance experiments. Magn Reson Chem 49, 543-548. DOI: 10.1002/mrc.2776

  • Hoppmann, C., Schmieder, P., Domaing, P., Vogelreiter, G., Eichhorst, J., Wiesner, B., Morano, I., Ruck-Braun, K. & Beyermann, M. (2011). Photocontrol of contracting muscle fibers. Angew Chem Int Ed Engl 50, 7699-7702. DOI: 10.1002/anie.201101398

  • Fidan, Z., Younis, A., Schmieder, P. & Volkmer, R. (2011). Chemical synthesis of the third WW domain of TCERG 1 by native chemical ligation. J Pept Sci 17, 644-649. DOI: 10.1002/psc.1383

  • Linser, R., Dasari, M., Hiller, M., Higman, V., Fink, U., Lopez del Amo, J. M., Markovic, S., Handel, L., Kessler, B., Schmieder, P., Oesterhelt, D., Oschkinat, H. & Reif, B. (2011). Proton-detected solid-state NMR spectroscopy of fibrillar and membrane proteins. Angew Chem Int Ed Engl 50, 4508-4512. DOI: 10.1002/anie.201008244

  • Schmiederer, T., Rausch, S., Valdebenito, M., Mantri, Y., Mosker, E., Baramov, T., Stelmaszyk, K., Schmieder, P., Butz, D., Muller, S. I., Schneider, K., Baik, M. H., Hantke, K. & Sussmuth, R. D. (2011). The E. coli siderophores enterobactin and salmochelin form six-coordinate silicon complexes at physiological pH. Angew Chem Int Ed Engl 50, 4230-4233. DOI: 10.1002/anie.201005792

  • Kohler, C., Lighthouse, J. K., Werther, T., Andersen, O. M., Diehl, A., Schmieder, P., Du, J., Holdener, B. C. & Oschkinat, H. (2011). The structure of MESD45-184 brings light into the mechanism of LDLR family folding. Structure 19, 337-348. DOI: 10.1016/j.str.2010.12.022

  • Christian, F., Szaszak, M., Friedl, S., Drewianka, S., Lorenz, D., Goncalves, A., Furkert, J., Vargas, C., Schmieder, P., Gotz, F., Zuhlke, K., Moutty, M., Gottert, H., Joshi, M., Reif, B., Haase, H., Morano, I., Grossmann, S., Klukovits, A., Verli, J., Gaspar, R., Noack, C., Bergmann, M., Kass, R., Hampel, K., Kashin, D., Genieser, H. G., Herberg, F. W., Willoughby, D., Cooper, D. M., Baillie, G. S., Houslay, M. D., von Kries, J. P., Zimmermann, B., Rosenthal, W. & Klussmann, E. (2011). Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. J Biol Chem 286, 9079-9096. DOI: 10.1074/jbc.M110.160614


  • Asami, S., Schmieder, P. & Reif, B. (2010). High Resolution 1H-Detected Solid-State NMR Spectroscopy of Protein Aliphatic Resonances: Access to Tertiary Structure Information. J Am Chem Soc 132, 15133-15135. DOI: 10.1021/ja106170h

  • Jurk, M., Dorn, M., Kikhney, A., Svergun, D., Gartner, W. & Schmieder, P. (2010). The switch that does not flip: the blue-light receptor YtvA from Bacillus subtilis adopts an elongated dimer conformation independent of the activation state as revealed by a combined AUC and SAXS study. J Mol Biol 403, 78-87. DOI: 10.1016/j.jmb.2010.08.036

  • Seedorff, S., Appelt, C., Beyermann, M. & Schmieder, P. (2010). Design, synthesis, structure and binding properties of PDZ binding, cyclic beta-finger peptides. Biochem Biophys Res Commun 395, 535-539. DOI: 10.1016/j.bbrc.2010.04.060

  • Röben, M., Hahn, J., Klein, E., Lamparter, T., Psakis, G., Hughes, J. & Schmieder, P. (2010). NMR spectroscopic investigation of mobility and hydrogen bonding of the chromophore in the binding pocket of phytochrome proteins. Chemphyschem 11, 1248-1257. DOI: 10.1002/cphc.200900897

  • Weng, A., Jenett-Siems, K., Schmieder, P., Bachran, D., Bachran, C., Gorick, C., Thakur, M., Fuchs, H. & Melzig, M. F. (2010). A convenient method for saponin isolation in tumour therapy. J Chromatogr B Analyt Technol Biomed Life Sci 878, 713-718. DOI: 10.1016/j.jchromb.2010.01.026


  • Hoppmann, C., Seedorff, S., Richter, A., Fabian, H., Schmieder, P., Ruck-Braun, K. & Beyermann, M. (2009). Light-directed protein binding of a biologically relevant beta-sheet. Angew Chem Int Ed Engl 48, 6636-6639.

  • Rutkowska, A., Beerbaum, M., Rajagopalan, N., Fiaux, J., Schmieder, P., Kramer, G., Oschkinat, H. & Bukau, B. (2009). Large-scale purification of ribosome-nascent chain complexes for biochemical and structural studies. FEBS Lett 583, 2407-2413.

  • Jacso, T., Grote, M., Schmieder, P., Schneider, E. & Reif, B. (2009). NMR assignments of the periplasmic loop P2 of the MalF subunit of the maltose ATP binding cassette transporter. Biomol NMR Assign 3, 21-23.

  • Ahsanullah, Schmieder, P., Kuhne, R. & Rademann, J. (2009). Metal-free, regioselective triazole ligations that deliver locked cis peptide mimetics. Angew Chem Int Ed Engl 48, 5042-5045.

  • Mroginski, M. A., von Stetten, D., Escobar, F. V., Strauss, H. M., Kaminski, S., Scheerer, P., Gunther, M., Murgida, D. H., Schmieder, P., Bongards, C., Gartner, W., Mailliet, J., Hughes, J., Essen, L. O. & Hildebrandt, P. (2009). Chromophore structure of cyanobacterial phytochrome Cph1 in the Pr state: reconciling structural and spectroscopic data by QM/MM calculations. Biophys J 96, 4153-4163.

  • Jacso, T., Grote, M., Daus, M. L., Schmieder, P., Keller, S., Schneider, E. & Reif, B. (2009). Periplasmic loop P2 of the MalF subunit of the maltose ATP binding cassette transporter is sufficient to bind the maltose binding protein MalE. Biochemistry 48, 2216-2225.

  • Weidauer, S. E., Schmieder, P., Beerbaum, M., Schmitz, W., Oschkinat, H. & Mueller, T. D. (2009). NMR structure of the Wnt modulator protein Sclerostin. Biochem Biophys Res Commun 380, 160-165.

  • Agarwal, V., Faelber, K., Schmieder, P. & Reif, B. (2009). High-Resolution Double-Quantum Deuterium Magic Angle Spinning Solid-State NMR Spectroscopy of Perdeuterated Proteins. J Am Chem Soc 131, 2-3.


  • Hahn, J., Strauss, H. M. & Schmieder, P. (2008). Heteronuclear NMR Investigation on the Structure and Dynamics of the Chromophore Binding Pocket of the Cyanobacterial Phytochrome Cph1. J Am Chem Soc 130, 11170-11178.

  • Coin, I., Beerbaum, M., Schmieder, P., Bienert, M. & Beyermann, M. (2008). Solid-phase synthesis of a cyclodepsipeptide: cotransin. Org Lett 10, 3857-3860.

  • Appelt, C., Wessolowski, A., Dathe, M. & Schmieder, P. (2008). Structures of cyclic, antimicrobial peptides in a membrane-mimicking environment define requirements for activity. J Pept Sci 14, 524-527.

  • Coin, I., Schmieder, P., Bienert, M. & Beyermann, M. (2008). The depsipeptide technique applied to peptide segment condensation: scope and limitations. J Pept Sci 14, 299-306.

  • Koehler, C., Bishop, S., Dowler, E. F., Schmieder, P., Diehl, A., Oschkinat, H. & Ball, L. J. (2008). Backbone and sidechain 1H, 13C and 15N resonance assignments of the Bright/ARID domain from the human JARID1C (SMCX) protein. Biomol NMR Assign 2, 9-11.

  • Hupfer, M., Glöss, S., Schmieder, P. & Grossart, H.-P. (2008). Methods for Detection and Quantification of Polyphosphate and Polyphosphate Accumulating Microorganisms in Aquatic Sediments. Int Rev Hydrobiol 93, 1-30.


  • Hahn, J., Kuhne, R. & Schmieder, P. (2007). Solution-state (15)N NMR spectroscopic study of alpha-C-phycocyanin: implications for the structure of the chromophore-binding pocket of the cyanobacterial phytochrome Cph1. Chembiochem 8, 2249-2255.

  • Scholz, I., Jehle, S., Schmieder, P., Hiller, M., Eisenmenger, F., Oschkinat, H. & van Rossum, B.-J. (2007). J-Deconvolution Using Maximum Entropy Reconstruction Applied to 13C−13C Solid-State Cross-Polarization Magic-Angle-Spinning NMR of Proteins. J Am Chem Soc 129, 6682-6683.

  • Dowler, E. F., Diehl, A., Schmieder, P., Brockmann, C., Elkins, J., Soundararajan, M., Oschkinat, H. & Ball, L. J. (2007). Backbone and sidechain 1H, 13C and 15N resonance assignments of the RGS domain from human RGS14. Biomol NMR Assign 1, 95-97.

  • Appelt, C., Schrey, A. K., Soderhall, J. A. & Schmieder, P. (2007). Design of antimicrobial compounds based on peptide structures. Bioorg Med Chem Lett 17, 2334-2337.

  • Fedorov, O. Y., Higman, V. A., Schmieder, P., Leidert, M., Diehl, A., Elkins, J., Soundararajan, M., Oschkinat, H. & Ball, L. J. (2007). Resonance assignment of the RGS domain of human RGS10. J Biomol NMR 38, 191.


  • Köhler, C., Andersen, O. M., Diehl, A., Krause, G., Schmieder, P. & Oschkinat, H. (2006). The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family. J Struct Funct Genomics 7, 131-138.

  • Rohmer, T., Strauss, H., Hughes, J., de Groot, H., Gartner, W., Schmieder, P. & Matysik, J. (2006). 15N MAS NMR studies of cph1 phytochrome: Chromophore dynamics and intramolecular signal transduction. J Phys Chem B 110, 20580-20585.

  • Mac, T. T., Beyermann, M., Pires, J. R., Schmieder, P. & Oschkinat, H. (2006). High yield expression and purification of isotopically labelled human endothelin-1 for use in NMR studies. Protein Expr Purif 48, 253-260.

  • Neuhof, T., Schmieder, P., Seibold, M., Preussel, K. & von Dohren, H. (2006). Hassallidin B--second antifungal member of the Hassallidin family. Bioorg Med Chem Lett 16, 4220-4222.

  • Joshi, M., Vargas, C., Boisguerin, P., Diehl, A., Krause, G., Schmieder, P., Moelling, K., Hagen, V., Schade, M. & Oschkinat, H. (2006). Discovery of low-molecular-weight ligands for the AF6 PDZ domain. Angew Chem Int Ed Engl 45, 3790-3795.

  • Hahn, J., Strauss, H. M., Landgraf, F. T., Gimenez, H. F., Lochnit, G., Schmieder, P. & Hughes, J. (2006). Probing protein-chromophore interactions in Cph1 phytochrome by mutagenesis. FEBS J 273, 1415-1429.


  • Appelt, C., Eisenmenger, F., Kuhne, R., Schmieder, P. & Soderhall, J. A. (2005). Interaction of the antimicrobial peptide cyclo(RRWWRF) with membranes by molecular dynamics simulations. Biophys J 89, 2296-2306.

  • Appelt, C., Wessolowski, A., Soderhall, J. A., Dathe, M. & Schmieder, P. (2005). Structure of the antimicrobial, cationic hexapeptide cyclo(RRWWRF) and its analogues in solution and bound to detergent micelles. Chembiochem 6, 1654-1662.

  • Strauss, H. M., Schmieder, P. & Hughes, J. (2005). Light-dependent dimerisation in the N-terminal sensory module of cyanobacterial phytochrome 1. FEBS Lett 579, 3970-3974.

  • Leitner, D., Wahl, M., Labudde, D., Krause, G., Diehl, A., Schmieder, P., Pires, J. R., Fossi, M., Wiedemann, U., Leidert, M. & Oschkinat, H. (2005). The solution structure of an N-terminally truncated version of the yeast CDC24p PB1 domain shows a different beta-sheet topology. FEBS Lett 579, 3534-3538.

  • Strauss, H. M., Hughes, J. & Schmieder, P. (2005). Heteronuclear solution-state NMR studies of the chromophore in cyanobacterial phytochrome Cph1. Biochemistry 44, 8244-8250.

  • Neuhof, T., Schmieder, P., Preussel, K., Dieckmann, R., Pham, H., Bartl, F. & von Dohren, H. (2005). Hassallidin A, a glycosylated lipopeptide with antifungal activity from the cyanobacterium Hassallia sp. J Nat Prod 68, 695-700.

  • Schubert, M., Labudde, D., Leitner, D., Oschkinat, H. & Schmieder, P. (2005). A modified strategy for sequence specific assignment of protein NMR spectra based on amino acid type selective experiments. J Biomol NMR 31, 115-128.


  • Gaiser, O. J., Ball, L. J., Schmieder, P., Leitner, D., Strauss, H., Wahl, M., Kuhne, R., Oschkinat, H. & Heinemann, U. (2004). Solution structure, backbone dynamics, and association behavior of the C-terminal BRCT domain from the breast cancer-associated protein BRCA1. Biochemistry 43, 15983-15995.

  • Brockmann, C., Diehl, A., Rehbein, K., Strauss, H., Schmieder, P., Korn, B., Kuhne, R. & Oschkinat, H. (2004). The oxidized subunit B8 from human complex I adopts a thioredoxin fold. Structure 12, 1645-1654.

  • Kahmann, J. D., Wecking, D. A., Putter, V., Lowenhaupt, K., Kim, Y. G., Schmieder, P., Oschkinat, H., Rich, A. & Schade, M. (2004). The solution structure of the N-terminal domain of E3L shows a tyrosine conformation that may explain its reduced affinity to Z-DNA in vitro. Proc Natl Acad Sci USA 101, 2712-2717.

  • Hupfer, M., Rube, B. & Schmieder, P. (2004). Origin and diagenesis of polyphosphate in lake sediments: A P-31-NMR study. Limnol Oceanogr 49, 1-10.


  • Otte, L., Wiedemann, U., Schlegel, B., Pires, J. R., Beyermann, M., Schmieder, P., Krause, G., Volkmer-Engert, R., Schneider-Mergener, J. & Oschkinat, H. (2003). WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains. Protein Sci 12, 491-500.


  • Schubert, M., Labudde, D., Oschkinat, H. & Schmieder, P. (2002). A software tool for the prediction of Xaa-Pro peptide bond conformations in proteins based on 13C chemical shift statistics. J Biomol NMR 24, 149-154.

  • Schubert, M., Kolbe, M., Kessler, B., Oesterhelt, D. & Schmieder, P. (2002). Heteronuclear multidimensional NMR spectroscopy of solubilized membrane proteins: resonance assignment of native bacteriorhodopsin. Chembiochem 3, 1019-23.

  • Patzelt, H., Simon, B., terLaak, A., Kessler, B., Kuhne, R., Schmieder, P., Oesterhelt, D. & Oschkinat, H. (2002). The structures of the active center in dark-adapted bacteriorhodopsin by solution-state NMR spectroscopy. Proc Natl Acad Sci USA 99, 9765-9770.


  • Kelly, M. J., Ball, L. J., Krieger, C., Yu, Y., Fischer, M., Schiffmann, S., Schmieder, P., Kuhne, R., Bermel, W., Bacher, A., Richter, G. & Oschkinat, H. (2001). The NMR structure of the 47-kDa dimeric enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase and ligand binding studies reveal the location of the active site. Proc Natl Acad Sci USA 98, 13025-13030.

  • Schubert, M., Oschkinat, H. & Schmieder, P. (2001). MUSIC and aromatic residues: amino acid type-selective (1)H-(15)N correlations, III. J Magn Reson 153, 186-192.

  • Schubert, M., Oschkinat, H. & Schmieder, P. (2001). Amino acid type-selective backbone 1H-15N-correlations for Arg and Lys. J Biomol NMR 20, 379-384.

  • Schubert, M., Oschkinat, H. & Schmieder, P. (2001). MUSIC, selective pulses, and tuned delays: amino acid type-selective (1)H-(15)N correlations, II. J Magn Reson 148, 61-72.


  • Ball, L. J., Kuhne, R., Hoffmann, B., Hafner, A., Schmieder, P., Volkmer-Engert, R., Hof, M., Wahl, M., Schneider-Mergener, J., Walter, U., Oschkinat, H. & Jarchau, T. (2000). Dual epitope recognition by the VASP EVH1 domain modulates polyproline ligand specificity and binding affinity. EMBO J 19, 4903-4914.

  • Schubert, M., Ball, L. J., Oschkinat, H. & Schmieder, P. (2000). Bridging the gap: A set of selective 1H-15N-correlations to link sequential neighbors of prolines. J Biomol NMR 17, 331-335.

  • Krause, E., Bienert, M., Schmieder, P. & Wenschuh, H. (2000). The Helix-Destabilizing Propensity Scale of d-Amino Acids:  The Influence of Side Chain Steric Effects. J Am Chem Soc 122, 4865-4870.


  • Schade, M., Turner, C. J., Kuhne, R., Schmieder, P., Lowenhaupt, K., Herbert, A., Rich, A. & Oschkinat, H. (1999). The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA. Proc Natl Acad Sci USA 96, 12465-12470.

  • Schubert, M., Smalla, M., Schmieder, P. & Oschkinat, H. (1999). MUSIC in triple-resonance experiments: amino acid type-selective (1)H-(15)N correlations. J Magn Reson 141, 34-43.

  • Smalla, M., Schmieder, P., Kelly, M., Ter Laak, A., Krause, G., Ball, L., Wahl, M., Bork, P. & Oschkinat, H. (1999). Solution structure of the receptor tyrosine kinase EphB2 SAM domain and identification of two distinct homotypic interaction sites. Protein Sci 8, 1954-1961.

  • Kelly, M. J., Krieger, C., Ball, L. J., Yu, Y., Richter, G., Schmieder, P., Bacher, A. & Oschkinat, H. (1999). Application of amino acid type-specific 1H- and 14N-labeling in a 2H-, 15N-labeled background to a 47 kDa homodimer: potential for NMR structure determination of large proteins. J Biomol NMR 14, 79-83.


  • Schmieder, P., Leidert, M., Kelly, M. & Oschkinat, H. (1998). Multiplicity-Selective Coherence Transfer Steps for the Design of Amino Acid-Selective Experiments-A Triple-Resonance Experiment Selective for Asn and Gln. J Magn Reson 131, 199-202.

  • Schultz, J., Hoffmuller, U., Krause, G., Ashurst, J., Macias, M. J., Schmieder, P., Schneider-Mergener, J. & Oschkinat, H. (1998). Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels. Nat Struct Biol 5, 19-24.


  • Schmieder, P., Stern, A. S., Wagner, G. & Hoch, J. C. (1997). Quantification of maximum-entropy spectrum reconstructions. J Magn Reson 125, 332-339.


  • Yang, J. X., Krezel, A., Schmieder, P., Wagner, G. & Havel, T. F. (1994). An evaluation of least-squares fits to COSY spectra as a means of estimating proton-proton coupling constants. II. Applications to polypeptides. J Biomol NMR 4, 827-844.

  • Schmieder, P., Stern, A. S., Wagner, G. & Hoch, J. C. (1994). Improved resolution in triple-resonance spectra by nonlinear sampling in the constant-time domain. J Biomol NMR 4, 483-490.


  • Schmieder, P., Stern, A. S., Wagner, G. & Hoch, J. C. (1993). Application of nonlinear sampling schemes to COSY-type spectra. J Biomol NMR 3, 569-576.

  • Schüler, W., Schmieder, P., Kessler, H., Christians, U., Holze, I., Sewing, K.-F. & Schiebel, H.-M. (1993). Structural Investigations of 13-O-Demethyl-FK506 and Its Isomers Generated by in vitro Metabolism of FK506 Using Human-Liver Microsomes. Helv Chim Acta 76, 2288-2302.


  • Schmieder, P., Ippel, J. H., van den Elst, H., van der Marel, G. A., van Boom, J. H., Altona, C. & Kessler, H. (1992). Heteronuclear NMR of DNA with the heteronucleus in natural abundance: facilitated assignment and extraction of coupling constants. Nucleic Acids Res 20, 4747-4751.

  • Schmieder, P. & Kessler, H. (1992). Determination of the ϕ angle in a peptide backbone by NMR spectroscopy with a combination of homonuclear and heteronuclear coupling constants. Biopolymers 32, 435-440.


  • Kurz, M., Schmieder, P. & Kessler, H. (1991). Hetloc, an Efficient Method for Determining Heteronuclear Long-Range Couplings with Heteronuclei in Natural Abundance. Angew Chem Int Ed Engl 30, 1329-1331.

  • Mierke, D. F., Schmieder, P., Karuso, P. & Kessler, H. (1991). Conformational Analysis of the cis- and trans-Isomers of FK506 by NMR and Molecular Dynamics. Helv Chim Acta 74, 1027-1047.

  • Seebach, D., Ko, S. Y., Kessler, H., Köck, M., Reggelin, M., Schmieder, P., Walkinshaw, M. D., Bölsterli, J. J. & Bevec, D. (1991). Thiocyclosporins: Preparation, Solution and Crystal Structure, and Immunosuppressive Activity. Helv Chim Acta 74, 1953-1990.

  • Schmieder, P., Kurz, M. & Kessler, H. (1991). Determination of heteronuclear long-range couplings to heteronuclei in natural abundance by two- and three-dimensional NMR spectroscopy. J Biomol NMR 1, 403-420.

  • Schmieder, P., Thanabal, V., McIntosh, L. P., Dahlquist, F. W. & Wagner, G. (1991). Measurements of H.alpha.-HN vicinal coupling constants in a protein with large line widths in a new 3D 1H-15N-13C quadruple resonance NMR experiment. J Am Chem Soc 113, 6323-6324.

  • Wagner, G., Schmieder, P. & Thanabal, V. (1991). A New H-1-N-15-C-13 Triple-Resonance Experiment for Sequential Assignments and Measuring Homonuclear H-Alpha-H-N Vicinal Coupling-Constants in Polypeptides. J Magn Reson 93, 436-440.

  • Schmieder, P., Domke, T., Norris, D. G., Kurz, M., Kessler, H. & Leibfritz, D. (1991). Editing of multiplicity in two- and three-dimensional heteronuclear NMR spectroscopy by fourier transformation of the pulse-angle dependency. J Magn Reson 93, 430-435.

  • Schmieder, P., Zimmer, S. & Kessler, H. (1991). Increased Resolution in Proton Detected Heteronuclear Nmr Experiments by Folding in the Hetero-Dimension. Magn Reson Chem 29, 375-380.

  • Kessler, H. & Schmieder, P. (1991). Heteronuclear two-and three-dimensional nmr spectroscopy of 13C in natural abundance by multiplicity selection and editing: Application to peptides. Biopolymers 31, 621-629.

  • Kessler, H., Schmieder, P., Kock, M. & Reggelin, M. (1991). Selection of Methyl Resonances in Proton-Detected Heteronuclear Shift Correlation, the HQQC Experiment. J Magn Reson 91, 375-379.


  • Kessler, H., Schmieder, P. & Oschkinat, H. (1990). 3D Heteronuclear NMR techniques for carbon-13 in natural abundance. J Am Chem Soc 112, 8599-8600.

  • Kessler, H., Schmieder, P., Kock, M. & Kurz, M. (1990). Improved resolution in proton-detected heteronuclear long-range correlation. J Magn Reson 88, 615-618.

  • Schmieder, P., Kessler, H. & Oschkinat, H. (1990). Fast Heteronuclear 3D NMR Spectroscopy. Angew Chem Int Ed Engl 29, 546-548.

  • Kessler, H., Schmieder, P. & Bermel, W. (1990). Complete assignment of the noncarbonylic carbon-13 resonances of Tendamistat. Biopolymers 30, 465-475.

  • Kessler, H., Gemmecker, G., Köck, M., Osowski, R. & Schmieder, P. (1990). Improvement of carbon-detected H,H-TOCSY experiments by employing a DEPT transfer. Magn Reson Chem 28, 62-67.


  • Kessler, H., Schmieder, P. & Kurz, M. (1989). Implementation of the DEPT Sequence in Inverse Shift Correlation - the DEPT-HMQC. J Magn Reson 85, 400-405.

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