Department Chemical Biology II (Christian Hackenberger)


117. M.-A. Kasper, L. Lassak, A.M. Vogl, I. Mai, J. Helma, D. Schumacher, C.P.R. Hackenberger

EurJOC 2022, DOI: 10.1002/ejoc.202101389
Bis-ethynylphosphonamidates as an Modular Conjugation Platform to Generate Multi-Functional Protein- and Antibody-Drug-Conjugates
Link to the article

116. A.F.L. Schneider, J. Kallen, J. Ottl, P.C. Reid, S. Ripoche, S. Ruetz, T.-M. Stachyra, S. Hintermann, C.E. Dumelin, C.P.R. Hackenberger, A.L. Marzinzik

RSC Chem. Biol. 2021, 2, 1661 - 1668
Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors
Link to the article

115. B. Yan, W. Li, C.P.R. Hackenberger

Org. Biomol. Chem. 2021, 19, 8014-8017
A silyl ether-protected building block for O-GlcNAcylated peptide synthesis to enable one-pot acidic deprotection
Link to the article

114. M.N. Stadtmueller, S. Bhatia, P. Kiran, M. Hilsch, L. Adam, B. Parshad, S. Klenk, K. Sellrie, D. Lauster, P. Seeberger, C.P.R. Hackenberger, A. Herrmann, R. Haag, T. Wolff

J. Med. Chem. 2021, 64(17), 12774-12789
Evaluation of Multivalent Sialylated Polyglycerols for Resistance and Broad Antiviral Activity against Influenza Viruses
Link to the article

113. A.F.L. Schneider, L. Benz, M. Lehmann, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2021, 60(40), 22075-22080
Cell-Permeable Nanobodies Allow Dual-Color Super-Resolution
Link to the article

Angew. Chem.2021, 133(40), 22246-22252
Zellpermeable Nanobodys ermöglichen Zwei-Farben-Superauflösungsmikroskopie in lebenden, nicht transfizierten Zellen
Link to the article

112. C.E. Stieger, L. Franz, F. Körlin, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2021, 60(28), 15359-15364
Diethynyl Phosphinates for Cysteine-Selective Protein Labeling and Disulfide Rebridging
Link to the article

Angew. Chem. 2021, 133(28), 15487-15492
Diethinylphosphinate für die Cystein-selektive Proteinmarkierung und Disulfid-Verbrückung
Link to the article


111. Y. Park*, A.L. Baumann*, H. Moon, S. Byrne, M.-A. Kasper, S. Hwang, H. Sun, M.-H. Baik, C.P.R. Hackenberger

Chem. Sci. 2021, 12, 8141-8148
The mechanism behind enhanced reactivity of unsaturated phosphorus(v) electrophiles towards thiols
Link to the article

110. A.F.L. Schneider, M. Kithil, M.C. Cardoso, M. Lehmann, C.P.R. Hackenberger

Nature Chemistry 2021, 13, 530-539
Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives
Link to the article

109. F.-X. Cantrelle, A. Loyens, X. Trivelli, O. Reimann, C. Despres, N.S. Gandhi, C.P.R. Hackenberger, I. Landrieu, C. Smet-Nocca

Front. Mol. Neurosci. 2021, 14:661368, DOI: 10.3389/fnmol.2021.661368
Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates
Link to the article

108. R. Brandt, S. Timm, J.L. Gorenflos López, J.K. Abledu, W.M. Kuebler, C.P.R. Hackenberger, M. Ochs, E. Lopez-Rodriguez

Front. Bioeng. Biotechnol. 2021, 8, Art. 614357, DOI: 10.3389/fbioe.2020.614357
Metabolic Glycoengineering Enables the Ultrastructural Visualization of Sialic Acids in the Glycocalyx of the Alveolar Epithelial Cell Line hAELVi
Link to the article

107. J. Schwach, K. Kolobynina, K. Brandstetter, M. Gerlach, P. Ochtrop, J. Helma, C.P.R. Hackenberger. H. Harz, M.C. Cardoso, H. Leonhardt, A. Stengl

ChemBioChem 2021, 22(7), 1205-1209
Site‐Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy
Link to the article

106. A. Hauser, E. Poulou, F. Müller, P. Schmieder, C.P.R. Hackenberger

Chem. Eur. J. 2021, 27, 2326-2331
Synthesis and Evaluation of Non-Hydrolyzable Phospho-Lysine Peptide Mimics
Link to the article

105. A. Hauser, S. Hwang, H. Sun, C.P.R. Hackenberger

Chem.Sci. 2020, 11, 12655-12661
Combining free energy calculations with tailored enzyme activity assays to elucidate substrate binding of a phospho-lysine phosphatase
Link to the article

104. C.P.R. Hackenberger, P.E. Dawson, Y.X. Chen, H. Hojo

J. Org. Chem. 2020, 85, 1328-1330
Modern Peptide and Protein Chemistry: Reaching New Heights
Link to the article

103. T. Zhaoxu, I.S. Donskyi, H. Qiao, Z. Zhu, W.E.S. Unger,  C.P.R. Hackenberger, W. Chen, M. Adeli, R. Haag

Adv. Funct. Mater. 2020, 30, 2000933
Graphene Oxide-Cyclic R10 Peptide Nuclear Translocation Nanoplatforms for the Surmounting of Multiple-Drug Resistance
Link to the article

102. A.L. Baumann, S. Schwagerus, K. Broi, K. Kemnitz-Hassanin, C.E. Stieger, N. Trieloff, P. Schmieder, C.P.R. Hackenberger

JACS 2020, 142(20), 9544-9552
Chemically Induced Vinylphosphonothiolate Electrophiles for Thiol-Thiol Bioconjugations
Link to the article

highlighted in: Synfacts 2020, 16(07), 0851, DOI: 10.1055/s-0040-1707878
Link to the article

101. P. Ochtrop, C.P.R. Hackenberger

Curr. Op. in Chem. Biology 2020, 58, 28-36
Recent advances of thiol-selective bioconjugation reactions (review)
Link to the article

100. D. Lauster, S. Klenk, K. Ludwig, S. Nojoumi, S. Behren, L. Adam, M. Stadtmüller, S. Saenger, S. Franz, K. Hönzke, L. Yao, U. Hoffmann, M. Bardua, A. Hamann, M. Witzenrath, L.E. Sander, T. Wolff, A.C. Hocke, S. Hippenstiel, S. DeCarlo, J. Neudecker, K. Osterrieder, N. Budisa, R.R. Netz, C. Böttcher, S. Liese, A. Herrmann, C.P.R. Hackenberger

Nature Nanotechnology 2020, 15, 373-379
Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry
Link to the article

highlighted in: ChemBioChem 2020, 22(3),478-480
Link to the article

99. M.-A. Kasper, M. Gerlach, A.F.L. Schneider, C. Groneberg, P. Ochtrop, S. Boldt, D. Schumacher, J. Helma, H. Leonhardt, M. Christmann, C.P.R. Hackenberger

ChemBioChem 2020, 21, 113-119
N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates
Link to the article

98. C. Apel, M.-A. Kasper, C.E. Stieger, C.P.R. Hackenberger, M. Christmann

Org. Lett. 2019, 21(24), 10043-10047
Protein Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanal
Link to the article

highlighted in: Synfacts 2020, 16(04), 0465
Protein Modification by Cope Rearrangement

97. A.L. Baumann, C.P.R. Hackenberger

Curr. Opin. Chem. Biol. 2019, 52, 39-46
Tag and release: strategies for the intracellular cleavage of protein conjugates (Review)
Link to the article

96. M.-A. Kasper, M. Glanz, A. Oder, P. Schmieder, J.P. von Kries, C.P.R. Hackenberger

Chem Sci. 2019, 10, 6322-6329
Vinylphosphonites for Staudinger-induced chemoselective peptide cyclizaton and functionalization

Dedicated to Prof. Ron Raines on the occasion of his 60th birthday
Link to the article

95. M.-A. Kasper, A. Stengl, P. Ochtrop, M. Gerlach, T. Stoschek, D. Schumacher, J. Helma, M. Penkert, E. Krause, H. Leonhardt, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2019, 58(34), 11631-11636
Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates
Link to the article

Angew. Chem. 2019, 131(34), 11757-11762
Link to the article

Dedicated to Prof. Sam Gellman on the occasion of his 60th birthday

highlighted in: ADC review 2019 (July)
New Reagents for the Rapid Generation of Efficacious Antibody-Drug Conjugates

highlighted in: Synfacts 2019, 15(10), 1189
Ethynylphosphonamidates in the Synthesis of Antibody–Drug Conjugates

94. M.-A. Kasper, M. Glanz, A. Stengl, M. Penkert, S. Klenk, T. Sauer, D. Schumacher, J. Helma, E. Krause, C. Cardoso, H. Leonhardt, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2019, 58(34), 11625-11630
Cysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations
Link to the article

Angew. Chem. 2019, 131(34), 11751-11756
Cysteinselektive phosphonamidatbasierte Elektrophile für modulare Biokonjugationen
Link to the article

Dedicated to Prof. Hans-Ulrich Reißig on the occasion of his 70th birthday

highlighted in: Synfacts 2019, 15(05), 0561
Ethynylphosphonamidate-Cysteine Bioconjugation

93. M. Penkert, A. Hauser, R. Harmel, D. Fiedler, C.P.R. Hackenberger, E. Krause

J. Am. Soc. Mass Spectrom. 2019, 30(9), 1578-1585
Electron Transfer/Higher Energy Collisional Dissociation of Doubly Charged Peptide Ions: Identificaton of Labile Protein Phosphorylations
Link to the article

92. S. Nojoumi, Y. Ma, A. Oder, S. Schwagerus, C.P.R. Hackenberger, N. Budisa

Int. J. Mol. Sci. 2019, 20(9), 2299
In-Cell Synthesis of Bioorthogonal Alkene Tag S-Allyl-Homocycteine and Its Coupling with Reprogrammed Translation
Link to the article

91. A. Stengl, M. Gerlach, M.-A. Kasper, C.P.R. Hackenberger, H. Leonhardt, D. Schumacher, J. Helma

OBC 2019, 17, 4964-4969
TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles
Link to the article

90. A.F.L. Schneider, A.L.D. Wallabregue, L. Franz, C.P.R. Hackenberger

Bioconjugate Chem. 2019, 30(2), 400-404
Targeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptides
Link to the article

89. A. Baumann, C.P.R. Hackenberger

CHIMIA 2018, 72(11), 802-808
Modern Ligations Methods to Access Natural and Modified Proteins
Link to the article

88. D. Schumacher, J. Helma, A.F.L. Schneider, H. Leonhardt, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2018, 57, 2314-2333
Chemical Functionalization Strategies and Intracellular Applications
Link to the article

Angew. Chem. 2018, 130, 2336-2357
Nanobodys: Strategien zur chemischen Funktionalisierung und intrazelluläre Anwendungen
Link to the article

87. K.D. Siebertz, C.P.R. Hackenberger

Chem. Comm. 2018, 54, 763-766
Chemoselective triazole-phosphonamidate conjugates suitable for photo-release

86. H.D. Herce, D. Schumacher, A.F.L. Schneider, A.K. Ludwig, F.A. Mann, M. Fillies, M.-A. Kasper, S. Reinke, E. Krause, H. Leonhardt, M.C. Cardoso, C.P.R. Hackenberger

Nature Chemistry 2017, 9, 762-771
Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells
Link to the article
Link to supplementary movie

highlighted in: Nature Chemistry 2017, 9, 727-728
Cytosolic delivery - Just passing through

highlighted in: c&en 2017, 95(30), 8-9
Drug Delivery -Two new ways to get proteins into cells

highlighted in: ChemBioChem 2017, 18(22), 2196-2198
Dodging Endosomes: Effective Cytosolic Antibody Delivery

85. A. Hauser, M. Penkert, C.P.R. Hackenberger

Acc. Chem. Res. 2017, 50(8), 1883-1893
Chemical Approaches to Investigate Labile Peptide and Protein Phosphorylation
Link to the article

84. D. Schumacher, O. Lemke, J. Helma, L. Gerszonowicz, V. Waller, T. Stoschek, P.M. Durkin, N. Budisa, H. Leonhardt, B.G. Keller, C.P.R. Hackenberger

Chemical Science 2017, 8, 3471-3478
Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling
Link to the article

83. D. Lauster, M. Glanz, M. Bardua, K. Ludwig, M. Hellmund, U. Hoffmann, A. Hamann, C. Böttcher, R. Haag, C.P.R. Hackenberger, A. Herrmann

Angew. Chem. Int. Ed. 2017, 56(21), 5931-5936
Multivalent Peptide-Nanoparticle Conjugates for Influenza-Virus Inhibition
Link to the article

Angew. Chem. 2017, 129(21), 6025-6030
Multivalente Peptid-Nanopartikel-Konjugate zur Hemmung des Influenzavirus
Link to the article

82. S. Hinderlich, R. Tauber, C.R. Bertozzi , C.P.R. Hackenberger

ChemBioChem 2017, 18(13), 1141-1145
Werner Reutter: A Visionary Pioneer in Molecular Glycobiology
Link to the article

81. S. Hinderlich, M. Neuenschwander, P.R. Wratil, A. Oder, M. Lisurek, L.D. Nguyen, J.P. von Kries, C.P.R. Hackenberger

ChemBioChem 2017, 18(13), 1279-1285
Small Molecules Targeting Human N-Acetylmannosamine Kinase
Link to the article

80. A.F.L. Schneider, C.P.R. Hackenberger

Curr. Opin. in Biotechnology 2017, 48, 61-68
Fluorescent labeling in living cells
Link to the article

79. M.P. Exner, T. Kuenzl, T.M.T. To, Z. Ouyang, S. Schwagerus, M.G. Hoesl, C.P.R. Hackenberger, M.C. Lensen, S. Panke, N. Budisa

ChemBioChem 2017, 18, 85-90
Design of S-Allylcysteine in Situ Production and Incorporation Based on a Novel Pyrrolysyl-tRNA Synthetase Variant
Link to the article

78. J. Bertran-Vicente, M. Penkert, O. Nieto-Garcia, J.-M. Jeckelmann, P. Schmieder, E. Krause, C.P.R. Hackenberger

Nature Comm. 2016, 7, Article number: 12703
Chemoselective synthesis and analysis of naturally occurring phosphorylated cysteine peptides
Link to the article

77. O. Reimann, C.P.R. Hackenberger

in "Tau Protein - Methods and Protocols", Verlag Humana Press, Caroline Smet-Nocca (ed.) 2017
Tag-Free Semi-Synthesis of the Tau Protein (Book Chapter)
Link to the article

76. N. Nischan, M.-A. Kasper, T. Mathew, C.P.R. Hackenberger

Org. Biomol. Chem. 2016, 14, 7500-7508
Bis(arylmethyl)-substituted unsymmetrical phosphites for the synthesis of lipidated peptides via Staudinger-phosphite reactions
Link to the article

75. D. Schumacher, C.P.R. Hackenberger, H. Leonhardt, J. Helma

J. Clin. Immunol. 2016, 36, 100-107
Current Status: Site-Specific Antibody Drug Conjugates
Link to the article

74. S. Schwagerus, O. Reimann, C. Despres, C. Smet-Nocca, C.P.R. Hackenberger

J. Pept. Sci. 2016, 22(5), 327-333
Semi-synthesis of a tag-free O-GlcNAcylated tau protein by sequential chemoselective ligation
Link to the article

73. O. Nieto-Garcia, P.R. Wratil, L.D. Nguyen, V. Böhrsch, S. Hinderlich, W. Reutter, C.P.R. Hackenberger

Chem. Sci. 2016, 7, 3928-3933
Inhibition of the key enzyme of sialic acid biosynthesis by C6-Se modified N-acetylmannosamine analogs
Link to the article

72. E. Hoffmann, K. Streichert, N. Nischan, C. Seitz, T. Brunner, S. Schwagerus, C.P.R. Hackenberger, M. Rubini

Molecular BioSystems 2016, 12, 1750-1755
Stabilization of bacterially expressed erythropoietin by single site-specific introduction of short branched PEG chains at naturally occurring glycosylation sites
Link to the article

71. C.P.R. Hackenberger, P.R. Chen

Curr. Opin. Chem. Biol. 2015, 28, VII-IX
Editorial overview: Synthetic biomolecules: Synthetic protein modifications - a giant leap towards understanding and generating biological functions
Link to the article

70. D. Schumacher, J. Helma, F.A. Mann, G. Pichler, F. Natale, E. Krause, M.C. Cardoso, C.P.R. Hackenberger, H. Leonhardt

Angew. Chem. Int. Ed. 2015, 54(46), 13787-13791
Versatile and Efficient Site-Specific Protein Functionalization by Tubulin Tyrosine Ligase
Link to the article

Angew. Chem. 2015, 127(46), 13992-13996
Vielseitige, effiziente und ortsspezifische Proteinfunktionalisierung durch das Enzym Tubulin-Tyrosin Ligase
Link to the article

69. M. Lehmann, B. Gottschalk, D. Puchkov, P. Schmieder, S. Schwagerus, C.P.R. Hackenberger, V. Haucke, J. Schmoranzer

Angew. Chem. Int. Ed. 2015, 54(45), 13230-13235
Multicolor Caged dSTORM Resolves the Ultrastructure of Synaptic Vesicles in the Brain
Link to the article
Angew. Chem. 2015, 127(45), 13428-13433
Link to the article

68. B. Kuropka, A. Witte, J. Sticht, N. Waldt, P. Majkut, C.P.R. Hackenberger, B. Schraven, E. Krause, S. Kliche, C. Freund

Mol. Cell. Proteomics 2015,14(11), 2961-2972
Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration
Link to the article

67. J. Bertran-Vicente, M. Schümann, C.P.R. Hackenberger, E. Krause

Anal. Chem. 2015, 87(14), 6990-6994
Gas-Phase Rearrangement in Lysine Phosphorylated Peptides During Electron-Transfer Dissociation Tandem Mass Spectrometry
Link to the article

66. M. Mühlberg, M. G. Hösl, C. Kühne, J. Dernedde, N. Budisa, C.P.R. Hackenberger

Beilstein JOC 2015, 11, 784-791
Orthogonal dual-modification of proteins for the engineering of multivalent protein scaffolds
Link to the article

65. J. Rosenlöcher, V. Böhrsch, M. Sacharjat, V. Blanchard, C. Giese, V. Sandig, C.P.R. Hackenberger, S. Hinderlich

Bioengineering 2015, 2, 213-234
Applying Acylated Fucose Analogues to Metabolic Glycoengineering
Link to the article

64. J. Bertran-Vicente, M. Schümann, P. Schmieder, E. Krause, C.P.R. Hackenberger

Org. Biomol. Chem. 2015, 13, 6839-6843
Direct access of site-specifically phosphorylated-lysine peptides from a solid-support
Link to the article
(The article is part of the themed collection: 2015 Hot Articles in Organic and Biomolecular Chemistry)


63. D. Agrawal, C.P.R. Hackenberger

in "Chemistry of Organo-hybrids: Synthesis and Characterization of Functional Nano-Objects", Wiley, Bernadette Charleux, Christophe Coperet, Emmanuel Lacote (Eds) 2015
Chemoselective Protein Modifications: Methods and Applications for the Functionalization of Viral Capsids (book chapter)
Link to the book


62. C. Witte, V. Martos, H.M. Rose, S. Reinke, S. Klippel, L. Schröder, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2015, 54(9), 2806-2810 (VIP-Paper)
Live-cell MRI of Xenon Hyper-CEST Biosensors Targeted to Metabolically Labeled Cell-Surface Glycans
Link to the article

Angew. Chem. 2015, 127(9), 2848-2852
Xenon-MRT an lebenden Zellen mit Hyper-CEST-Biosensoren für metabolisch markierte Glykane an der Zelloberfläche
Link to the article

61. N. Nischan, H.D. Herce, F. Natale, N. Bohlke, N. Budisa, M.C. Cardoso, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2015, 54(6), 1950-1953
Covalent Attachment of Cyclic TAT Peptides to GFP Results in Protein Delivery into Live Cells with Immediate Bioavailability
Link to the article

Angew. Chem. 2015, 127(6), 1972-1976
Kovalente Verknüpfung cyclischer TAT-Peptide mit GFP resultiert in der direkten Aufnahme in lebende Zellen mit sofortiger biologischer Verfügbarkeit
Link to the article

60. M.R.J. Vallée, P. Majkut, D. Krause, M. Gerrits, C.P.R. Hackenberger

Chem. Eur. J. 2015, 21(3), 970-974
Chemoselective Bioconjugation of Triazole Phosphonites in Aqueous Media
Link to the article

59. O. Reimann, C. Smet-Nocca, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2015, 54(1), 306-310
Traceless Purification and Desulfurization of Tau Protein Ligation Products
Link to the article

Angew. Chem. 2015, 127(1), 311-315
Spurlose Aufreinigung und Desulfurierung von Ligationsprodukten des Tau-Proteins
Link to the article

58. O. Reimann, M. Glanz, C.P.R. Hackenberger

Bioorganic & Medicinal Chemistry 2015, 23(12), 2890-2894
Native chemical ligation between asparagine and valine: Application and limitations for the synthesis of tri-phosphorylated C-terminal tau
Link to the article

57. M. Schmitz, M. Kuhlmann, O. Reimann, C.P.R. Hackenberger, J. Groll

Biomacromolecules 2015, 16(4), 1088-1994
Side-Chain Cysteine-Functionalized Poly(2-oxazoline)s for Multiple Peptide Conjugation by Native Chemical Ligation
Link to the article

56. M. Kuhlmann, O. Reimann, C.P.R. Hackenberger, J. Groll

Macromol. Rapid Commun. 2015, 36, 472
Cysteine-Functional Polymers via Thiol-ene Conjugation
Link to the article

55. N. Nischan, C.P.R. Hackenberger

JOC 2014, 79(22), 10727-10733
Site-specific PEGylation of Proteins: Recent Developments
Link to the article

54. D. Schumacher, C.P.R. Hackenberger

Curr. Opin. Chem. Biol. 2014, 22, 62-69
More than add-on: chemoselective reactions for the synthesis of functional peptides and proteins
Link to the article

53. J. Bertran-Vicente, R.A. Serwa, M. Schümann, P. Schmieder, E. Krause, C.P.R. Hackenberger

J. Am Chem. Soc. 2014, 136(39), 13622-13628
Site-Specifically Phosphorylated Lysine Peptides
Link to the article

52. M. Mühlberg, K.D. Siebertz, B. Schlegel, P. Schmieder, C.P.R. Hackenberger

Chem. Commun. 2014, 50(35), 4603-4606
Controlled thioamide vs. amide formation in the thioacid-azide reaction under acidic aqueous conditions
Link to the article

51. C.F.W. Becker, A. Brik, P. Dawson, C.P.R. Hackenberger

J. Pept. Sci. 2014, 20, 63
Chemical protein synthesis
Link to the article


50. P. Majkut, I. Claußnitzer, H. Merk, C. Freund, C.P.R. Hackenberger, M. Gerrits

PLoS ONE 2013, 8(12): e82352
Completion of Proteomic Data Sets by Kd Measurement Using Cell-Free Synthesis of Site-Specifically Labeled Proteins

Link to the article

49. N. Nischan, A. Chakrabarti, R.A. Serwa, P.H.M. Bovee-Geurts, R. Brock, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 201352(45), 11920-11924
Stabilization of Peptides for Intracellular Applications by Phosphoramidate-Linked Polyethylene Glycol Chains
Link to the article

Angew. Chem. 2013, 125(45), 12138-12142
Stabilisierung von Peptiden für intrazelluläre Anwendungen mit Phosphoramidat-verzweigten Polyethylenglycol-Ketten
Link to the article

48. M.R.J. Vallée, L.M. Artner, J. Dernedde, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2013, 52, 9504-9508 (VIP Paper)
Alkyne Phosphonites for Sequential Azide-Azide Couplings
Link to the article

Angew. Chem. 2013,125, 9682-9686 (VIP Paper)
Alkinphosphonite für sequenzielle Azid-Azid-Kupplungen
Link to the article

47. J. Bertran-Vicente, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2013, 52(24), 6140-6142
A Supramolecular Peptide Synthesizer (Highlight)
Link to the article

Angew. Chem. 2013, 125(24), 6256-6258
Ein supramolekularer Peptidsynthesizer (Highlight)
Link to the article

46. S. Sowa, M. Mühlberg, K.M. Pietrusiewicz, C.P.R. Hackenberger

Bioorg. Med. Chem. 2013, 21, 3465-3472
Traceless Staudinger acetylation of azides in aqueous buffers
Link to the article

45. D. Agrawal, C.P.R. Hackenberger

Indian J. Chem. 2013, 52A, 973-991
Site-specific chemical modifications of proteins

44. V. Böhrsch, T. Mathew, M. Zieringer, M.R.J. Vallée, L.M. Artner, J. Dernedde, R. Haag, C.P.R. Hackenberger

Org. Biomol. Chem. 2012, 10, 6211-6216
Chemoselective Staudinger-phosphite reaction of symmetrical glycosyl-phosphites with azido-peptides and polygycerols
(10-year-anniversairy issue of Org. Biomol. Chem.)
Link to the article


43. H. Möller, V. Böhrsch, J. Bentrop, J. Bender. S. Hinderlich, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2012, 51(24), 5986-5990
Glycan-Specific Metabolic Oligosaccharide Engineering of C7-Substituted Sialic Acids
Link to the article

Angew. Chem. 2012, 124(24), 6088-6092
Glycan-spezifisches metabolisches Oligosaccharid-Engineering von C7-substituierten Sialinsäuren
Link to the article

42. M. Broncel, E. Krause, D. Schwarzer, C.P.R. Hackenberger

Chem. Eur. J. 2012, 18, 2488-2492
The Alzheimer's Disease Related Tau Protein as a New Target for Chemical Protein Engineering (selected as VIP-paper)
Link to the article

41. L.M. Artner, L. Merkel, N. Bohlke, F. Beceren-Braun, C. Weise, J. Dernedde, N. Budisa, C.P.R. Hackenberger

Chem. Commun. 2012, 48, 522-524
Site-selective modification of proteins for the synthesis of structurally defined multivalent scaffolds
Link to the article

40. M.R.J. Vallée, P. Majkut, I. Wilkening, C. Weise, G. Müller, C.P.R. Hackenberger

Org. Lett. 2011, 13, 5440-5443
Staudinger-Phosphonite Reactions for the Chemoselective Transformation of Azido-Containing Peptides and Proteins
Link to the article

39. I. Wilkening, G. del Signore, W. Ahlbrecht, C.P.R. Hackenberger

Synthesis 2011, 17, 2709-2720
Lewis Acid or Alkyl Halide Promoted Rearrangements of Phosphor- and Phosphinimidates to N,N-Disubstituted Phosphor- and Phosphinamidates (Feature Article)
Link to the article

38. H. Möller, V. Böhrsch, C.P.R. Hackenberger, S. Hinderlich

J. Carb. Chem. 2011, 4-6, 334-346
N-Azidoacetylomannosamine and N-Azidoacetylgalactosamine Incorporation into N-Glycans of Recombinantly Expressed Human Lactotransferrin by Metabolic Oligosaccharide Engineering
Link to the article

37. H. Möller, V. Böhrsch, L. Lucka, C.P.R. Hackenberger, S. Hinderlich

Mol. Biosyst. 2011, 7, 2245-2251
Efficient metabolic oligosaccharide engineering of glycoproteins by UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) knock-down
Link to the article

36. P. Majkut, V. Böhrsch, R. Serwa, M. Gerrits, C.P.R. Hackenberger

in "Methods in Molecular Biology, Vol. 794: Unnatural Amino Acids", Springer, Loredano Pollegioni, Stefano Servi (eds) 2011
Site-Specific Modification of Proteins by the Staudinger-Phosphite Reaction (Book chapter)
Link to the article

35. C. Smet-Nocca, M. Broncel, J.-M. Wieruszeski, C. Tokarski, X. Hanoulle, A. Leroy, I. Landieu, C. Rolando, G. Lippens, C.P.R. Hackenberger

Mol. Biosyst. 2011, 7, 1420-1429
Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation
Link to the article

34. I. Wilkening, G. del Signore, C.P.R. Hackenberger

Chem. Commun. 2011, 47, 349-351
Synthesis of phosphonamidate peptides by Staudinger reactions of silylated phosphinic acids and esters
Emerging Investigator Issue
Link to the article

33. M.M. Chen, A.I. Bartlett, P.S. Nerenberg, C.T. Friel, C.P.R. Hackenberger, C.M. Stultz, S.E. Radford, B. Imperiali

Proc. Natl. Acad. Sci. 2010, 107, 22528-22533
Perturbing the folding energy landscape of the bacterial immunity protein Im7 by site-specific N-linked glycosylation
Link to the article

32. R. Serwa, B. Horstmann, P. Majkut, J.-M. Swiecicki, M. Gerrits, E. Krause, C.P.R. Hackenberger

Chemical Science 2010, 1, 596-602
Site-specific PEGylation of proteins by a Staudinger-phosphite reaction
Link to the article

31. M. Mühlberg, D. Jaradat, R. Kleineweischede, I. Papp, D. Dechtrirat, S. Muth, M. Broncel, C.P.R. Hackenberger

Bioorg. Med. Chem. 2010, 18, 3679-3686
Acidic and basic deprotection strategies of borane-protected phosphinothioesters for the traceless Staudinger ligation
Link to the article

30. R. Serwa, J.-M. Swiecicki, D. Homann, C.P.R. Hackenberger

J. Pep. Sci. 2010, 16, 563-567
Phosphoramidate-peptide synthesis by solution and solid-phase Staudinger-phosphite reactions
Link to the article

29. D.M.M. Jaradat, H. Hamouda, C.P.R. Hackenberger

Eur. J. Org. Chem. 2010, 26, 5004-5009
Solid-Phase Synthesis of Phosphoramidate-Linked Glycopeptides
Link to the article

28. M. Broncel, S.C. Wagner, C.P.R. Hackenberger, B. Koksch

Chem. Commun. 2010, 46, 3080-3082
Enzymatically triggered amyloid formation: an approach for studying peptide aggregation
Link to the article

27. M. Broncel, J.A. Falenski, S.C. Wagner, C.P.R. Hackenberger, B. Koksch

Chem. Eur. J. 2010, 16, 7881-7888
How Post-Translational Modifications Influence Amyloid Formation: A Systematic Study of Phosphorylation and Glycosylation in Model Peptides
Link to the article

26. M. Broncel, S. C. Wagner, K. Paul, C.P.R. Hackenberger, B. Koksch

Org. Biomol. Chem. 2010, 8, 2575-2579
Towards understanding secondary structure transitions: phosphorylation and metal coordination in model peptides
Link to the article

25. V. Böhrsch, R. Serwa, P. Majkut, E. Krause, C.P.R. Hackenberger

Chem. Commun. 2010, 46, 3176-3178
Site-specific functionalisation of proteins by a Staudinger-type reaction using unsymmetrical phosphites
Link to the article

24. C.P.R. Hackenberger, J.W. Bode, D. Schwarzer

in "Amino Acids, Peptides and Proteins in Organic Chemistry", Wiley-VCh, Andrew B. Huges (ed.) 2010, 445-494
Chemoselective Peptide Ligation - A Privileged Tool for Protein Synthesis (Book Chapter)
Link to the article

23. A.K. Udit, C.P.R. Hackenberger, M.K. O'Reilly

ChemBioChem 2010, 11, 481-484
Chemically Tailored Multivalent Virus Platforms - From Drug Delivery to Catalysis (Highlight)
Link to the article

22. V. Böhrsch, C.P.R. Hackenberger

ChemCatChem 2010, 2, 243-245
Suzuki-Miyaura Couplings on pProteins - a Simple and Ready-to-use Catalytic System in Water (Highlight)
Link to the article

21. C.P.R. Hackenberger, H.-D. Arndt, D. Schwarzer

Chemie in unserer Zeit 2010, 44, 198-206
Semisynthese: Ein zentrales Werkzeug für die Chemische Biologie (Review)
Link to the article

20. H.-D. Arndt, C.P.R. Hackenberger, D. Schwarzer

Chemie in unserer Zeit 2010, 44, 130-137
Semisynthese: Chemie mit den Molekülen der Natur (Review)
Link to the article

19. R. Serwa, I. Wilkening, G. del Signore, M. Mühlberg, I. Claußnitzer, C. Weise, M. Gerrits, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2009, 48, 8234-8239
Chemoselective Staudinger-Phoshpite Reaction of Azides for the Phosphorylation of Proteins
Link to the article

Angew. Chem. 2009, 121, 8382-8387
Chemoselektive Staudinger-Phosphit-Reaktion von Aziden für die Phosphorylierung von Proteinen
Link to the article

18. C.P.R. Hackenberger, D. Schwarzer

Angew. Chem. Int. Ed. 2008, 47, 10030-10074
Chemoselective Ligation and Modification Strategies of Peptides and Proteins
Link to the article

Angew. Chem. 2008, 120, 10182-10228
Chemoselektive Ligations- und Modifikationsstrategien für Peptide und Proteine
Link to the article

17. I. Wilkening, G. del Signore, C.P.R. Hackenberger

Chem. Commun. 2008, 25, 2932-2934
Synthesis of N,N-disubstituted phosphoramidates via a Lewis acid-catalyzed phosphorimidate rearrangement
Link to the article

16. R. Kleineweischede, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2008, 47, 5984-5988
Chemoselective Peptide Cyclization by Traceless Staudinger Ligation
Link to the article

Angew. Chem. 2008, 120, 6073-6078
Chemoselektive Peptidcyclisierung über spurlose Staudinger-Ligation
Link to the article

15. C.P.R. Hackenberger, S. Hinderlich

ChemBioChem 2007, 8, 1763-1765
Chemoselective Labeling of Engineered Fucosylated Glycoproteins
Link to the article

14. C.P.R. Hackenberger

ChemBioChem 2007, 8, 1221-1223
A Synthetic Kiss of Death: Expressed Protein Ligation of a Ubiquitin-Peptide Conjugate
Link to the article

13. C.P.R. Hackenberger

Org. Biomol. Chem. 2006, 4, 2291-2295
The reduction of oxidized methionine residues in peptide thioesters with NH4I/Me2S
Link to the article

12. C.P.R. Hackenberger

Chemie in unserer Zeit (ChiuZ) 2006, 40, 174-183
Proteinstrukturen aus dem Chemie-Baukasten. Definierte Peptidarchitekturen
Link to the article

11. C.P.R. Hackenberger, M. Chen, B. Imperiali

Bioorg. Med. Chem. 2006, 14, 5043-5048
Expression of N-terminal Cys-protein fragments using an intein refolding strategy
Link to the article

10. C.P.R. Hackenberger, C.T. Friel, S.E. Radford, B. Imperiali

J. Am. Chem. Soc. 2005, 127, 12882-12889
Semisynthesis of a Glycosylated Im7 Analogue for Protein Folding Studies
Link to the article

9. C.P.R. Hackenberger, M.K. O'Reilly, B. Imperiali

J. Org. Chem. 2005, 70, 3574-3578
Improving Glycopeptide Synthesis: A Convenient Protocol for the Preparation of ß-Glycosylamines and the Synthesis of Glycopeptides
Link to the article

8. C. Bolm, M. Verrucci, O. Simic, C.P.R. Hackenberger

Adv. Synth. Catal. 2005, 347, 1696-1700
Ethylene-Bridged Bissulfoximines in Copper-Catalyzed Enantioselective Hetero-Diels-Alder Reactions
Link to the article

7. C.P.R. Hackenberger, G. Raabe, C. Bolm

Chem. Eur. J. 2004, 10, 2942-2952
Synthetic and Spectroscopic Investigation of N-Acylated Sulfoximines
Link to the article

6. C.P.R. Hackenberger, I. Schiffers, J. Runsink, C. Bolm

J. Org. Chem. 2004, 69, 739-743
General Synthesis of Unsymmetrical Norbornane Scaffolds as Inducers for Hydrogen Bond Interactions in Peptides
Link to the article

5. C. Bolm, I. Schiffers, I. Atodiresei, C.P.R. Hackenberger

Tetrahedron: Asymmetry 2003, 14, 3455-3467
An alkaloid-mediated desymmetrization of meso-anhydrides via a nucleophilic ring opening with benzyl alcohol and its application in the synthesis of highly enantiomerically enriched ß-amino acids
Link to the article

4. C. Bolm, D. Müller, C. Dalhoff, C.P.R. Hackenberger, E. Weinhold

Bioorg. Med. Chem. Lett. 2003, 13, 3207-3211
The stability of pseudopeptides bearing sulfoximines as chiral backbone modifying element towards proteinase K
Link to the article

3. C. Bolm, C.P.R. Hackenberger, O. Simic, M. Verrucci, D. Müller, F. Bienewald

Synthesis 2002, 7, 879-887
N-Alkylation of Sulfoximines: A Mild Synthetic Procedure for the Introduction of Carbon Side-Chains via an Acylation and Reduction Route

2. C. Bolm, D. Müller, C.P.R. Hackenberger

Org. Lett. 2002, 4, 893-897
Turn Formation Initiated by a Bissulfoximine Motif: Synthesis and Structural Investigation
Link to the article

1. S.M. Yu, D.T. McQuade, M.A. Quinn, C.P.R. Hackenberger, M.P. Krebs, A.S. Polans and S.H. Gellman

Protein Sci. 2000, 9, 2518-2527
An improved tripod amphiphile for membrane protein solubilization
Link to the article

Book Chapters and Further Articles

5. A. Hauser, C.E. Stieger, C.P.R. Hackenberger

Beyond Phosphate Esters: Synthesis of Unusually Phosphorylated Peptides and Proteins for Proteomic Research (book chapter), 2021, in "Total Chemical Synthesis of Proteins", A. Brik, P. Dawson, L. Liu eds.
Link to the article

4. D. Schumacher, H. Leonhardt, C.P.R. Hackenberger, J. Helma

Methods Mol Biol 2019, 2033, 167-189
One-Step Fluorescent Protein Labeling by Tubulin Tyrosine Ligase
Link to the article

3. M. Gerlach, T. Stoschek, H. Leonhardt, C.P.R. Hackenberger, D. Schumacher, J. Helma

Methods Mol Biol 2019, 2012, 327-355
Tubulin Tyrosine Ligase-Mediated Modification of Proteins.
Link zum Artikel

2. D. Schumacher, J. Helma-Smets, C.P.R. Hackenberger, H. Leonhardt

Chem. Unserer Zeit 2018, 52, 80-82
New generation of antibody-drug conjugates: start-ups.
Link to the article

1. A. Fukuoka, G. Gasser, D. Guldi, C.P.R. Hackenberger, T. Hisatomi, P. Knochel, J. Kubota, S. Matile, F. Wuerthner, J. Yoon

Chem Sci 2017, 8, 4158
Outstanding Reviewers for Chemical Science in 2016
Link to the article

Academic Publications

C.P.R. Hackenberger

Habilitation, FU Berlin, 2011
Chemie und Kunst

C.P.R. Hackenberger

Dissertation, RWTH Aachen, 2003
Untersuchungen zu chemischen und strukturbildenden Eigenschaften von Sulfoximidoylen und Sulfoximin-ß-Carbonylen: Definierte Sekundärstruktur in Pseudopeptiden, Oligomeren und molekularen Gerüstsystemen

C.P.R. Hackenberger

Masters Thesis, Wisconsin/Madison, 1999
Thermal Stability of Tripod Amphiphiles: A Kinetic Investigation of the Cope-Elimination of Amine-Oxides Designed to Promote Membrane Protein Crystallization

Other Publications, Book Reviews, Conference Reports, Scientific Journalism

M.B. Jaffee, C.P.R. Hackenberger

Angew. Chem. Int. Ed. 2015, 54(9), 2591-2592
Concepts and Case Studies in Chemical Biology. Edited by Herbert Waldmann and Petra Janning (Book Review)
Link to the article

K. Siebertz, O. Reimann, C.P.R. Hackenberger

q&more 02.15 2015
Alzheimer: die Suche nach einem Ausweg

O. Reimann, C.P.R. Hackenberger

Nachrichten aus der Chemie 2013, 61(3), 298-303
Trendbericht Biochemie 2012

M. Mühlberg, V. Böhrsch, C.P.R. Hackenberger

Angew. Chem. 2009, 121, 8321
Angew. Chem. Int. Ed. 2009, 48, 8175
Chemical Biology. Learning through Case Studies. Herausgegeben von Herbert Waldmann und Petra Janning (Book review)

C.P.R. Hackenberger, H. Wegener, A. Zumbuehl

Angew. Chem. 2008, 120, 5578-5581
Angew. Chem. Int. Ed. 2008, 47, 5496-5499
Stereochemie in Bürgenstock: chemische Biologie und organische Synthese im Blickpunkt (Konferenzbericht)

C.P.R. Hackenberger

Nachrichten aus der Chemie 2006, 1, 64
14. Nachwuchsiwssenschaftlersymposium Bioorganische Chemie conference report
Author "RÖMPP-online"
Thieme Verlag, ab Oktober 2007

C.P.R. Hackenberger

Nachrichten aus der Chemie 2004, 1, 29
Deutsche Hochschulen – Fit für den internationalen Wettbewerb? Conference Report

E.C. Ullrich, U. Kallfass, C.P.R. Hackenberger

Nachrichten aus der Chemie 2002, 50, 1359-1362
Öffentlichkeitsarbeit für die Chemie

C. Bolm, C.P.R. Hackenberger, J. Rudolph

Adv. Materials 2002, 14, 168-169
Catalysis from A to Z; A Concise Encyclopedia, B. Cornils, W. A. Herrmann, R. Schlögl, C.-H. Wong (eds.) book review

Author within the television broadcast Quarks und Co.
The Star of Bethlehem

broadcasted on 12/18/2001 on WDR
Editorial office assistant and author within the WDR-Series
WissQuiz, broadcasted from 12/26 – 12/30/2001 on WDR
Various publications and reports for the JCF Spring Symposium
Euregionale 2002 in Aachen

Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)

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