Cellular Imaging

Publications 1997-2019

2019

Song K, Gras C, Capin G, Gimber N, Lehmann M, Mohd S, Puchkov D, Rödiger M, Wilhelmi I, Daumke O, Schmoranzer J, Schürmann A, Krauss M. A SEPT1-based scaffold is required for Golgi integrity and function. J Cell Sci 132(3), (2019). pii. jcs2255557 doi: 10.1242/jcs.225557

Vukićević T, Hinze C, Baltzer S, Himmerkus N, Quintanova C, Zühlke K, Compton F, Ahlborn R, Dema A, Eichhorst J, Wiesner B, Bleich M, Schmidt-Ott KM, Klussmann E. Fluconazole Increases Osmotic Water Transport in Renal Collecting Duct through Effects on Aquaporin-2 Trafficking. J Am Soc Nephrol. 30(5):795-810. (2019)

2018

Vukoja A, Rey U, Petzoldt AG, Ott C, Vollweiter D, Quentin C, Puchkov D, Reynolds E, Lehmann M, Hohensee S, Rosa S, Lipowsky R, Sigrist SJ, Haucke V. Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles. Neuron. 99(6):1216-1232.e7. doi: 10.1016/j.neuron.2018.08.004. (2018)

Wang H, Lo WT, Vujičić Žagar A, Gulluni F, Lehmann M, Scapozza L, Haucke V, Vadas O. Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain Module. Mol Cell. 71(2):343-351 (2018)

Lück JC, Puchkov D, Ullrich F, Jentsch TJ. LRRC8/VRAC anion channels are required for late stages of spermatid development in mice. J Biol Chem. 293: 11796-11808 (2018)

Tezner A., Naughton M, Gebolys K, Eichhorst J, Sala E, Villacañas Ó, Walther T. Decarboxylation of Ang-(1-7) to Ala1-(Ang-(1-7) leads to segnificant changes in pharmacodynamics. Eur J Pharmacol. 833:116-123 (2018)

Fulterer A, Andlauer TFM, Ender A, Maglione M, Eyring K, Woitkuhn J, Lehmann M, Matkovic-Rachid T, Geiger JRP, Walter AM, Nagel KI, Sigrist SJ. Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses. Cell Rep. 23(5): 1259-1274 (2018)

Maares M, Keil C, Thomson S, Günzel D, Wiesner B, Haase H. Characterization of Caco-2 cells stably expressing the protein-based zinc probe eCalwy-5 as a model system for investigating intestinal zinc transport. J Trace Elem Med Biol. 49:296-304 (2018)

Fischer J, Kleinau G, Rutz C, Zwanziger D, Khajavi N, Müller, A, Rehders M, Brix K, Worth CL, Führer D, Krude H, Wiesner B, Schülein R, Biebermann H. Evidence of G-protein-coupled receptor and substrate transporter heteromerization at single molecule level. Cell Mol Life Sci. 75(12): 2227-2239 (2018)

Hussain A, Pooryasin A, Zhang M, Loschek LF, LLa Fortezza M, Friedrich AB, Blais CM, Ücpunar HK, Yépez VA, Lehmann M, Grompel N, Gagneur J, Sigrist SJ, Grunwald Kadow IC. Inhibition of oxidative stress in cholinergic projection neurons fully rescues aging associated olfactory circuit degeneration in Drosophila. Elife. 7, e32018 (2018)

Schrade K, Tröger J, Eldahshan A, Zühlke K, Abdul Azeez KR, Elkins JM, Neuenschwander M, Oder A, Elkewedi M, Jaksch S, Andrae K, Li J, Fernandes J, Müller PM, Grunwald S, Marino SF, Vukicevic T, Eichhorst J, Wiesner B, Weber M, Kapiloff M, Rocks O, Daumke O, Wieland T, Knapp S, von Kries JP, Klussmann E. An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells. PlosOne. 13(1): e0191423 (2018)

Scior A, Buntru A, Arnsburg K, Ast A, Iburg M, Juenemann K, Pigazzini ML, Mlodny B, Puchkov D, Priller J, Wanker EE, Prigione A, Kirstein J. Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex. EMBO J. 37(2):282-299 (2018)

2017

Walter AM, Müller R, Tawfik B, Wierda KD, Pinheiro PS, Nadler A, McCarthy AW, Ziomkiewicz I, Kruse M, Reither G, Rettig J, Lehmann M, Heucke V, Hille B, Schultz C, Sorensen JB. Phosphatidylinositol 4.5-bisphosphate optical uncaging potentiates exocytosis. Elife. 6, e20203 (2017)

Gerth F, Jäpel M, Pechstein A, Kochlamazashvili G, Lehmann M, Puchkov D, Onofri F, Benfenati F, Nikonenko AG, Maritzen T, freund C, Haucke V. Intersectin associates with synapsin and regulates ist nanoscale localization and function. Proc Natl Acad Sci U S A. 114(45):12057-12062 (2017)

Lo WT, Vuijcic Zagar A, Gerth F, Lehmann M, Puchkov D, Krylova O, Freund C, Scapozza L, Vadas O, Haucke V. A Coincidence Detection Mechanism Controls PX-BAR Domain-MEdiated Ecdocytotic Membrane Remodeling via an Allosteric Structural Switch. Dev Cell. 43(4):522-529.e4 (2017)

Gehne N, Lamik A, Lehmann M, Haseloff RF, Andjelkovic AV, Blasig IE. Cross-over endocytosis of claudins is mediated by interactions via their extracellular loops. PLoS One. 12(8): e0182106 (2017)

Marter K, Wetzel J, Eichhorst J, Eremina N, Leboulle G, Barth A, Wiesner B, Eisenhardt D. Inhibition of Protein Synthesis with Highly Soluble Caged Compounds. ChemistrySelect. 2(22):6212-6217 (2017)

Blex c, Michaelis S, Schrey AK, Furkert J, Eichhorst J, Bartho K, Gyapon Quast F, Marais A, Hakelberg M, Gruber U, Niquet S, Popp O, Kroll F, Sefkow M, Schülein R, Dreger M. Köster H. Targeting G Protein-Coupled Receptors by Capture Compound MAss Spectrometry: A Case Study with Sertindole. Chembiochem. 18(16):1639-1649 (2017)

Oberheide K, Puchkov D, Jentsch TJ. Loss of the Na+/H+ exchanger NHE8 causes male infertility in mice by disrupting acrosome formation. J Biol Chem. 292(26):10845-10854 (2017)

Schöneberg J, Lehmann M*, Ullrich A, Posor Y, Lo WT, Lichtner G, Schmoranzer J, Haucke V, Noé F. Lipid-mediated PX-BAR domain recruitment couples local membrane constriction to endocytic vesicle fission. Nat Commun. 8:15873 (2017)(* shared first author)

Rathjen T, Yan X, Kononenko NL, Ku MC, Song K, Ferrarese L, Tarallo V, Puchkov D, Kochlamazashvili G, Vrachs S, Varela L, Szigeti-Buck K, Yi CX, Schriever SC, Tattikota SG, Carlo AS, Moroni M, Siemens J, Heuser A, van der Weyden L, Birkenfeld AL, Niedorf T, Poulet JFA, Horvath TL, Tschöp MH, Heinig M, Trajkovski M, Haucke V, Poy MN. Regulation of body weigt and energy homeostasis by neuronal cell adhesion molecule 1. Nat Neurosci. 20(8):1096-1103 (2017)

Leonhardt J, Villela DC, Teichmann A, Münter LM, Mayer MC, Mardahl M, Kirsch S, Namsolleck P, Lucht K, Benz V, Alemina N, Daniell N, Horiuchi M, Iwai M, Multhaup G, Schülein R, Bader M, Santos RA, Unger T, Steckelings UM. Evidence for Heterodimerization and Funktional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS. Hypertension. 69(6):1128-1135 (2017)

Kononenko NL, Claßen GA, Kuipers M, Puchkov D, Maritzen T, Tempes A, Malik AR, Skalecka A, Bera S, Jaworski J, Haucke V. Retrograde transport of TrkB-containing autophagosomes via adapter AP-2 mediates neuronal complexity and prevents neurodegeneration. Nat Commun. 8:14819 (2017)

Lorenz C, Lesimple P, Bukowiecki R, Zink A, Inak G, Mlody B, Singh M, Semter M, Mah N, Auré K, Leong M, Zabiegalov O, Lyras EM, Pfiffer V, Fauler B, Eichorst J, Wiesner B, Huebner N, Priller J, Mielke T, Meierhofer D, Izsvák Z, Meier JC, Bouillaud F, Adjaye J, Schuelke M, Wamker EE, Lombès A, Prigione A. Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders. Cell Stem Cell. S1934-5909(16)30469-6 (2017)

Soykan T, Kaempf N, Skaba T, Vollweiter D, Goerdele F, Puchkov D, Kononenko NL, Haucke V. Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly. Neuron 93:854-866.e4 (2017)

2016

Schröter F, Jakop U, Teichmann A, Haralampiev I, Tannert A, Wiesner B, Müller P, Müller K. Lipid dynamics in boar sperm studied by advanced fluorescence imaging techniques. Eur Biophys J. 45, 149-163 (2016)

Ketel K, Krauss M, Nicot AS, Puchkov D, Wieffer M, Müller R, Subramanian D, Schultz C, Laporte J, Haucke V. A phosphoinositide conversion mechanism for exit from endosomes. Nature 529, 408-412 (2016)

Schütz I, Lopez-Hernandez T, Gao Q, Puchkov D, Jabs S, Nordmeyer D, Schmudde M, Rühl E, Graf CM, Haucke V. Lyposomal dysfunction caused by cellular accumulation of silica nanoparticles. J Biol Chem. 291, 14170-14184 (2016)

Draffehn S, Eichhorst J, Wiesner B, Kumke MU. Insight into the Modification of Polymeric Micellar and Liposomal Nanocarriers by Fluorescein-labeled Lipids and Uptake Mediating Lipopeptides. Lannuir. 32, 6928-6929 (2016)

Gödde K, Gschwend O, Puchkov D, Pfeffer CK, Carleton A, Jetsch TJ. Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination. Nat Commun. 7, 12043 (2016)

Theillet FX, Binolfi A, Bekei B, Martorana A, Rose HM, Stuiver M, Verzini S, Lorenz D, van Rossum M, Goldfarb D, Selenko, P. Structural disorder of monomeric α-synuclein persists in mammalian cells. Nature 530, 45-50 (2016)

Lehmann M, Lichtner G, Klenz H, Schmoranzer, J. Novel organic dyes for multicolor localization-based super resolution microscopy. J Biophotonics 9, 161-170 (2016)

Sydow K, Nikolenko H, Dorenz D, Müller RH, Dathe M. Lipopeptide-based micellar and liposomal carriers: Influence of surface charge and particle size on cellular uptake into blood brain barrier cells. Euro J Pharm Biopharm. 109, 130-139 (2016)

2015

Bukowiecki R, Lesimple P, Lorenz C, Leong M, Singh M, Auré K, Semtner M, L'Hermitte-Stead C, Wiesner B, Izsvák Z, Mielke T, Meier JC, Adjaye J, Wanker EE, Schuelke M, Lombès A, Prigione A. iPSC-derived neural progenitors carrying a MT-ATP6 mutation exhibit mitochondrial hyperpolarization and calcium-related defects. Mitochondrion 24, S28 (2015)

Voget M, Lorenz D, Lieber-Teneorio E, Hauck R, Meyer M, Cieslicki M. Is transmission electron microscopy (TEM) a promising approach for qualitative and quantitative investigations of polymyxin B and miconazole interactions with cellular and subcellular structures of Staphylococcus pseudintermedius, Escherichia coli, Pseudomonas aeruginosa and Malassezia pachydermatis? Vet Microbiol. 182, 261-270 (2015)

Herrada I, Samson C, Velours C, Renault L, Östlund C, Chervy P, Puchkov D, Worman HJ, Buendia B, Zinn-Justin S. Muscular Dystrophy Mutations Impair the Nuclear Envelope Emerin Self-assembly Properties. ACS Chem Biol. 10, 2733-2742 (2015)

Koo SJ, Kochlamazashvili G, Rost B, Puchkov D, Gimber N, Lehmann M, Tadeus G, Schmoranzer J, Rosenmund C, Haucke V, Maritzen T. Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission. Neuron 88, 330-344 (2015)

Lehmann M, Gottschalk B, Puchkov D, Schmieder P, Schwagerus S, Hackenberger CP, Haucke V, Schmoranzer J. Multicolor Caged dSTORM Resolves the Ultrastructure of Synaptic Vesicles in the Brain. Angew Chem Int Ed Engl. 54, 13230-13235 (2015)

Grzesik P, Kreuchwig A, Rutz C, Furkert J, Wiesner B, Schuelein R, Kleinau G, Gromoll J, Krause G. Differences in signal activation by LH and hCG are mediated by the LH/CG receptor's extracellular hinge region. Front Endocrinol 6, 140-154 (2015)

Kaempf N, Kochlamazashvili G, Puchkov D, Maritzen T, Bajjalieh SN, Kononenko NL, Haucke V. Overlapping functions of stonin 2 and SV2 in sorting of the calcium sensor synaptotagmin 1 to synaptic vesicles. Proc Natl Acad Sci U S A 112, 7297-7302 (2015)

Cording J, Günther R, Vigolo E, Tscheik C, Winkler L, Schlattner I, Lorenz D, Haseloff RF, Schmitt-Ott KM, Wolburg H, Blasig I. Redoc regulation of cell contacts by tricellulin and occludin: redox-sensitive cysteine sites in tricellulin regulate both tri- and bicellular junctions in tissue barriers as shown in hypoxia and ischemia. Antioxid redox Signal 23, 1035-1049 (2015)

Waiczies S, Lepore S, Sydow K, Drechsler S, Ku MC, Martin C, Lorenz D, Schütz I, Reimann HM, Purfürst B, Dieringer MA, Waiczies H, Dathe M, Pohlmann A, Niendorf T. Anchoring dipalmitoyl phosphoethanolamine to nanoparticles boosts cellular uptake and fluorine-19 magnetic resonance signal. Sci rep. 5, 8427 (2015)

Weng A, Manunta MD, Thakur M, Gilabert-Oriol R, Tagalakis AD, Eddaoudi A, Munye MM, Vink CA, Wiesner B, Eichhorst J, Melzig MF, Hart SL. Improved intracellular delivery of peptide- and  lipid-nanoplexes by natural glycocides. J Control Release 206, 75-90 (2015)

Opitz R, Müller M, Reuter C, Barone M, Soicke A, Roske Y, Piotukh K, Huy P, Beerbaum M, Wiesner B, Beyermann M, Schmieder P, Freund C, Volkmer R, Oschkinat H, Schmalz HG, Kühne R. A molecular toolkit to inhibit proline-rich motif-mediated protein-protein interactions. Proc Natl Acad Sci U S A 112, 5011-5016 (2015)

2014

Baletta A, Lorenz D, Rummel A, Gerhard R, Bigalke H, Wegner F. Clostridium difficile toxin B inhibits the secretory response of human mast cell line-1 (HMC-1) cells stimulated with high free-Ca2+ and GTPγS. Toxicology 328C, 48-56 (2014)

Ni C, Wang C, Zhang J, Qu L, Liu X, Lu Y, Yang W, Deng J, Lorenz D, Gao P, Meng Q, Yan X, Blasig IE, Qin Z. Interferon-γ Safeguards Blood-Brain Barrier during Experimental Autoimmune Encephalomyelitis. Am J Pathol. 184, 3308-3320 (2014)

Weinert S, Jabs S, Hohensee S, Chan WL, Kornak U, Jentsch TJ. Transport activity and presence of CIC-7/Ostm1 complex account for different cellular functions. EMBO Rep. 15, 784-791 (2014)

Hoeg-Beiler MB, Sirisi S, Orozco IJ, Ferrer I, Hohensee S, Auberson, Gödde K, Vilches C, de Heredia ML, Nunes V, Estévez R, Jentsch TJ. Disrupting MLC1 and GlialCAM and CIC-2 interactions in leukodystrophy entails glial chloride channel dyfunction. Nat. Commun. 5, 3475 (2014)

Kononenko NL, Puchkov D, Classen GA, Walter AM, Pechstein A, Sawade L, Kaempf N, Trimbuch T, Lorenz D, Rosenmund C, Maritzen T, Haucke V. Clathrin/AP-2 mediate synaptic vesicle reformation from endosome-like vacuoles but are not essential for membrane retrieval at central synapses. Neuron 82, 981-988 (2014)

Teichmann A, Gibert A, Lampé A, Grzesik P, Rutz C, Furkert J, Schmoranzer J, Krause G, Wiesner B, Schülein R. The specific monomer/dimer equilibrium of the corticotropin releasing factor type 1 is established in the endoplasmic reticulum. J Biol Chem. 289, 24250-24262 (2014)

Podufall J, Tian R, Knoche E, Puchkov D, Walter AM, Rosa S, Quentin C, Vukoja A, Jung N, Lampe A, Wichmann C, Böhme M, Depner H, Zhang YQ, Schmoranzer J, Sigrist SJ, Haucke V. A presynaptic role for the cytomatrix protein GIT in synaptic vesicle recycling. Cell rep7, 1417-1425 (2014)

Gilabert-Oriol R, Thakur M, von Mallinckrodt B, Bhargava C, Eichhorst J, Wiesner B, Melzig MF, Fuchs H, Weng A. Reporter assay for endo/lysomal escape of toxin-based thearpeutics. Toxins (Basel) 22, 1644-1666 (2014)

Kanzleiter T, Rath M, Penkov D, Puchkov D, Schulz N, Blasi F, Schürmann A. Pknox1/Prep1 regulates mitochondrial oxidative phosphorylation cpmponents in skeletal muscle. Mol Cell Biol. 34, 290-298 (2014)

Grzesik P, Teichmann A, Furkert J, Rutz C, Wiesner B, Kleinau G, Schülein R, Gromoll J, Krause G. Differences between lutropin-mediated and choriogonadotropin-mediated receptor activation. FEBS J. 281, 1479-1492 (2014)

2013

Balletta A, Lorenz D, Rummel A, Gerhard R, Bigalke H, Wegner F. Human mast cell line-1 (HMC-1) cells exhibit a membrane capacitance increase when dialysed with high free-Ca2+ and GTPγS containig intracellular solution. Eur J Pharmacol. 720, 227-236 (2013)

Bogum J, Faust D, Zühlke K, Eichhorst J, Moutty MC, Furkert J, Eldahshan A, Neuenschwander M, von Kries JP, Wiesner B, Trimpert C, Deen PM, Valenti G, Rosenthal W, Klussmann E. Small-Molecule Screening Identifies Modulators of Aquaporin-2 Trafficking. J Am Soc Nephrol. 24, 744-758 (2013)

Shetty A, Sytnyk V, Leshchyns'ka I, Puchkov D, Haucke V, Schachner M. The neural cell adhesion molecule promotes maturation of the presynaptic endocytotic machinery by switching synaptic vesicle recycling from adaptor protein 3 (AP-3)- to AP-2-dependent meachnisms. J Neurosci. 33, 16828-16845 (2013)

Schwefel D, Arasu BS, Marino SF, Lamprecht B, Köchert K, Rosenbaum E, Eichhorst J, Wiesner B, Behlke J, Rocks O, Mathas S, Daumke O. Structural Insights into the Mechanism of GTPase Activation in the GIMAP Family. Structure 21, 550-559 (2013)

Thakur M, Wenig A, Pieper A, Mergel K, von Mallinckrodt B, Gilabert-Oriol R, Görick C, Wiesner B, Eichhorst J, Melzig MF, Fuchs H. Macromolecular interactions of triterpenoids and targeted toxins: Role of saponins charge. Int J Biol Macromol. 61C, 285-294 (2013)

Posor Y, Eichhorn-Gruenig M, Puchkov D, Schöneberg J, Ullrich A, Lampe A, Müller R, Zarbakhsh S, Gulluni F, Hirsch E, Krauss M, Schultz C, Schmoranzer J, Noé F, Haucke V. Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate. Nature 499, 233-237 (2013)

Kononenko NL, Diril MK, Puchkov D, Kintscher M, Koo SJ, Pfuhl G, Winter Y, Wienisch M, Klingauf J, Breustedt J, Schmitz D, Maritzen T, Haucke V. Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2. PNAS USA 110, E526-535 (2013)

Gilabert-Oriol R, Thakur M, von Mallinckrodt B, Hug T, Wiesner B, Eichhorst J, Melzig MF, Fuchs H, Wenig A. Modified trastuzumab and cetuximab mediate efficient toxin delivery while retaining antibody-dependent cell-mediated cytotoxicity in target cells. Mol Pharm. 10, 4347-4357 (2013)

Puchkov D, Haucke V. Greasing the synaptic vesicle cycle by membrane lipids. Trends Cell Biol. 23, 493-503 (2013)

2012

Orthmann A, Zeisig R, Süss R, Lorenz D, Lemm M, Fichtner I: Treatment of Experimental Brain Metastasis with MTO- Liposomes: Impact of Fluidity and LRP-Targeting on the Therapeutic Result. Pharm Res. 29, 1949-59 (2012)

Rossa J, Lorenz D, Ringling M, Veshnyakova A, Piontek J. Overexpression of claudin-5 but not claudin-3 induces formation of trans-interaction-dependent multilamellar bodies. Ann NY Acad Sci., 1257, 59-66 (2012)

Teichmann A, Rutz C, Kreuchwig A, Krause G, Wiesner B, Schülein R: The pseudo signal peptide of the corticotropin-releasing factor receptor type 2A prevents receptor oligomerization. J Biol Chem. 287, 27265-27274 (2012)

Schaal J, Dekowski B, Wiesner B, Eichhorst J, Marter K, Vargas C, Keller S, Eremina N, Barth A, Baumann A, Eisenhardt D, Hagen V: Coumarin-Based Octopamine Phototriggers and their Effects on an Insect Octopamine Receptor. Chembiochem. 13, 1458-1464 (2012)

Otten C, van der Ven PF, Lewrenz I, Paul S, Steinhagen A, Busch-Nentwich E, Eichhorst J, Wiesner B, Stemple D, Strähle U, Fürst DO, Abdelilah-Seyfried S: Xirp proteins mark injured skeletal muscle in zebrafish. PLoS One. 7, e31041 (2012)

Ridelis I, Schmidt A, Teichmann A, Furkert J, Wiesner B, Schülein R: Use of Kikume green-red fusions to study the influence of pharmacological chaperones on trafficking of G protein-coupled receptors. FEBS Lett. 586, 784-791 (2012)

Biebermann H, Winkler F, Handke D, Teichmann A, Gerling B, Cameron F, Eichhorst J, Grüters A, Wiesner B, Kühnen P, Krude H, Kleinau G: New pathogenic thyrotropin receptor mutations decipher differentiated activity switching at a conserved helix 6 motif of family A GPCR. J Clin Endocrinol Metab. 97, E228-232 (2012)

Weng A, Thakur M, von Mallinckrodt B, Beceren-Braun F, Gilabert-Oriol R, Wiesner B, Eichhorst J, Boettger S, Melzig MF, Fuchs H: Saponins modulate the intracellular trafficking of protein toxins. J Control Release 164, 74-86 (2012)

Richter M, Chakrabarti A, Ruttekolk IR, Wiesner B, Beyermann M, Brock R, Rademann J: Multivalent design of apoptosis-inducing Bid-BH3 peptide-oligosaccharides boosts the intracellular activity at identical overall peptide concentrations. Chemistry 18, 16708-16715 (2012)

Hoppmann C, Barucker C, Lorenz D, Multhaupt G, Beyermann M: Light-controlled toxicity of engineered amyloid beta-peptides. Chembiochem. 13, 2657-2660 (2012)

2011

Christian F, Szaszák M, Friedl S, Drewianka S, Lorenz D, Goncalves A, Furkert J, Vargas C, Schmieder P, Götz F, Zühlke K, Moutty M, Göttert H, Joshi M, Reif B, Haase H, Morano I, Grossmann S, Klukovits A, Verli J, Gáspár R, Noack C, Bergmann M, Kass R, Hampel K, Kashin D, Genieser HG, Herberg FW, Willoughby D, Cooper DM, Baillie GS, Houslay MD, von Kries JP, Zimmermann B, Rosenthal W, Klussmann E. Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. J Biol Chem. 286, 9079-9096 (2011)

Schmidt V, Baum K, Lao A, Rateitschak K, Schmitz Y, Teichmann A, Wiesner B, Petersen CM, Nykjaer A, Wolf J, Wolkenhauer O, Willnow TE: Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. EMBO J. 31, 187-200 (2011)

Oehlke J, Ehrlich A, Krause E, Pritz S, Wiesner B, Beyermann M: Growth factor- and adhesion protein-like components of fetal calf serum can significantly enhance the intracellular delivery of Peptide nucleic acids. Nucleic Acid Ther. 21, 285-291 (2011)

Westendorf C, Schmidt A, Coin I, Furkert J, Ridelis I, Zampatis D, Rutz C, Wiesner B, Rosenthal W, Beyermann M, Schülein R: Inhibition of biosynthesis of human endothelin B receptor by the cyclodepsipeptide cotransin. J Biol Chem. 286, 35588-35600 (2011)

Hoppmann C, Schmieder P, Domaing P, Vogelreiter G, Eichhorst J, Wiesner B, Morano I, Rück-Braun K, Beyermann M: Photocontrol of contracting muscle fibers. Angew Chem Int Ed Engl. 50, 7699-7702 (2011)

2010

Mollajew R, Zocher F, Horner A, Wiesner B, Klussmann E, Pohl P: Routes of epithelial water flow: aquaporins versus cotransporters. Proc Natl Acad Sci U S A. 107, 20299-20304 (2010)

Schwefel D, Fröhlich C, Eichhorst J, Wiesner B, Behlke J, Aravind L, Daumke O: Structural basis of oligomerization in septin-like GTPase of immunity-associated protein 2 (GIMAP2). Biophys J. 99, 3647-3656 (2010) 

Nedvetsky PI, Tabor V, Tamma G, Beulshausen S, Skroblin P, Kirschner A, Mutig K, Boltzen M, Petrucci O, Vossenkämper A, Wiesner B, Bachmann S, Rosenthal W, Klussmann E: Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase. J Am Soc Nephrol. 21, 1645-1656 (2010)

Schulz K, Rutz C, Westendorf C, Ridelis I, Vogelbein S, Furkert J, Schmidt A, Wiesner B, Schülein R: The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity. J Biol Chem. 285, 32878-32887 (2010)

Orthmann A, Zeisig R, Koklic T, Sentjurc M, Wiesner B, Lemm M, Fichtner I: Impact of membrane properties on uptake and transcytosis of colloidal nanocarriers across an epithelial cell barrier model. J Pharm Sci. 99, 2423-2433 (2010)

Hundsrucker C, Skroblin P, Christian F, Zenn HM, Popara V, Joshi M, Eichhorst J, Wiesner B, Herberg FW, Reif B, Rosenthal W, Klussmann E: Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. J Biol Chem. 285, 5507-5521 (2010)

Turner Y, Wallukat G, Säälik P, Wiesner B, Pritz S, Oehlke J: Cellular uptake and biological activity of peptide nucleic acids conjugated with peptides with and without cell-penetrating ability. J Pept Sci. 16, 71-80 (2010)

2009

Schmidt A, Wiesner B, Weißhart K, Schulz K, Furkert J, Rosenthal W, Schülein R: Use of Kaede fusions to visualize recycling of G protein-coupled receptors. Traffic 10, 2-15 (2009)

Hava D, Forster U, Matsuda U, Cui S, Link BA, Eichhorst J, Wiesner B, Chitnis A, Abdelilah-Seyfried S: Apical membrane maturation and cellular rosette formation during morphogenesis of the zebrafish lateral line. J Cell Sci. 122, 687-695 (2009)

Walter T, Albrecht D, Becker M, Schubert M, Kouznetsova E, Wiesner B, Maul B, Schliebs R, Grecksch G, Furkert J, Sterner Kock A, Schultheiss HP, Becker A, Siems WE: Improved Learning and Memory in Aged Mice Deficient in Amyloid b Degrading Neutral Endopepdidase. PLoS ONE 4, 1-11 (2009)

Kilic F, Kashikar ND, Schmidt R, Alvarez L, Dai L, Weyand I, Wiesner B, Goodwin N, Hagen V, Kaupp UB: Caged Progesterone: A New Tool for Studying Rapid Nongenomic Actions of Progesterone. J. Am. Chem. Soc. 131, 4027-4030 (2009)

2008

Piontek J, Winkler L, Wolburg H, Müller SL, Zuleger N, Piehl C, Wiesner B, Krause G, Blasig IE: First homophilic interaction determinants between strand-forming claudins identified. FASEB 22, 146-158 (2008)

Bit-Avragim N, Rohr S, Rudolph F, van der Ven P, Fürst D, Eichhorst J, Wiesner B, Abdelilah-Seyfried S: Nuclear localization of the zebrafish tight junction protein nagie oko. Dev. Dyn. 237, 83-90 (2008)

Hagen V, Dekowski B, Kotzur N, Lechler R, Wiesner B, Briand B, Beyermann M: {7-[Bis(carboxymethyl)amino]coumarin-4-yl}methoxycarbonyl Derivatives for Photorelease of Carboxylic Acids, Alcohols/Phenols, Thioalcohols/ Thiophenols, and Amines. Chemistry 14, 1621-1627 (2008)

Jundt F, Acikgöz Ö, Kwon SH, Anagnostopoulos I, Wiesner B, Mathas S, Lim HY, Hummel M, Stein H, Reichardt HM, Dörken B: Aberrant expression of Notch1 interferes with the B-lymphoid phenotype of neoplastic B cells in classical Hodgkin lymphoma. Leukemia 22, 1587-1594 (2008)

Schwieger I, Lautz K, Krause E, Rosenthal W, Wiesner B, Hermosilla R: Derlin-1 and p97/VCP Mediate the ER-Associated Degradation of Human V2 Vasopressin Receptors. Mol. Pharmacol.73, 697-708 (2008)

Sun X, Wiesner B, Lorenz D, Papsdorf G, Pankow K; Wang P, Dietrich N, Siems WE, Maul B: Interactions of angiotensin-converting enzyme (ACE) with membrane-bound carboxypeptidase M (CPM) - a new function of ACE. Biol Chem. 389, 1477-1485 (2008)

2007

Stefan E, Wiesner B, Baillie GS, Mollajew R, Henn V, Lorenz D, Furkert J, Santamaria K, Nedvetsky PI, Hundsrucker C, Beyermann M, Krause E, Pohl P, Gall I, MacIntyre AN, Bachmann S, Houslay MD, Rosenthal W, Klussmann E: Compartmentalization of cAMP-dependent signalling by phosphodiesterase-4D is involved in the regulation of vasopresin-mediated water reabsorption in renal principal cells. J Am Soc Nephrol 18, 199-212 (2007)

Nedvetsky PI, Stefan S, Frische S, Santamaria K, Wiesner B, Valenti G, Hammer III JA, Nielsen S, Goldenring RJ, Rosenthal W, Klussmann E: A role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle. Traffic 8,110-123 (2007)

Zeisig R, Koklic T, Wiesner B, Fichtner I, Sentjurc M: Increase in fluidity in the membrane of MT3 breast cancer cells correlates with the enhanced cell adhesion in vitro an increased lung metastasis in NOD/SCID mice. Arch Biochem Biophys 459, 98-106 (2007)

Oueslati M, Hermosilla R, Schönenberger E, Oorschot V, Beyermann M, Wiesner B, Schmidt A, Klumpermann J, Rosenthal W, Schülein R: Rescue of a nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutant by cell-penetrating peptides. J Biol Chem. 282, 20676-20685 (2007)

Vossenkaemper A, Nedvetsky PI, Wiesner B, Furkert J, Rosenthal W, Klussmann E: Microtubules are needed for the perinuclear positioning of aquaporin-2 after its endocytic retrieval in renal principal cells. Am J Physiol Cell Physiol. 293, C1129-1138 (2007)

Lygren B, Carlson CR, Santamaria K, Lissandron V, McSorley T, Litzenburg J, Lorenz D, Wiesner B, Rosenthal W, Zaccolom M, Taskén K, Klussmann E: AKAP complex regulates Ca2+ re-uptake into heart sracoplasmatic reticulum. EMBO reports 8, 1061-1067 (2007)

Plant TD, Zöllner C, Kepura F, Mousa SS, Eichhorst J, Schaefer M, Furkert J, Stein J, Oksche A: Endothelin potentiates TRPV1 via ET1 receptor-mediated activation of protein kinase C. Mol Pain 14, 3-35 (2007)

2006

Rutz C, Renner A, Alken M, Schulz K, Beyermann M, Wiesner B, Rosenthal W, Schülein R. The corticotrophin-releasing factor receptor type 2a contains an N-terminal pseudo signal peptide. J Biol Chem. 281, 24910-24921 (2006)

2005

Oehlke J, Lorenz D, Wiesner B, Bienert M: Studies on the cellular uptake of substance P and lysine-rich, KLA-derived model peptides. J. Mol. Recognit. 18, 50-59 (2005)

Geissler D, Antonenko YN, Schmidt R, Keller S, Krylova O, Wiesner B, Bendig J, Pohl P, Hagen V: (Coumarin-4-yl)methyl esters as highly efficient, ultrafast phototriggers for protons and their application to acidifying membrane surfaces. Angew. Chem. Int. Ed. 44, 1195-1198 (2005)

Hagen V, Dekowski B, Nache V, Schmidt R, Geißler D, Lorenz D, Eichhorst J, Keller S, Kaneko H, Benndorf K, Wiesner B: Coumarinylmethyl Esters for Ultrafast Release of High Concentrations of Cyclic Nucleotides upon One- and Two-Photon Photolysis. Angew. Chem. Int. Ed. 44(48), 7887-7891 (2005)

Lödige I, Marg A, Wiesner B, Malecova B, Oelschläger T, Vinkemeier U: Nuclear export determines the cytokine sensitivity of STAT transcription factors. J. Biol. Chem. 280, 43087-43099 (2005)

Kraetke O, Wiesner B, Eichhorst J, Furkert J, Bienert M, Beyermann M: Dimerization of Corticotropin-Releasing Factor receptor type 1 is not coupled to ligand binding. J. Recept Signal Transduct Res. 25, 251-276 (2005)

Giebing G, Tölle M, Juergensen J, Eichhorst J, Furkert J, Beyermann M, Neuschäfer-Rube F, Rosenthal W, Zidek W, van der Giet M, Oksche A: Arrestin-independent internalization and recycling of the urotensin receptor contribute to long-lasting urotensin II-mediated vasoconstriction. Circ. Res. 97, 707 – 715 (2005)

2004

Tsunoda S, Wiesner B, Lorenz D, Rosenthal W, Pohl P: Aquaporin 1, nothing but a water channel. J. Bio. Chem. 279, 11364-11367 (2004)

Mathas S, Lietz A, Anagnostopoulos I, Hummel F, Wiesner B, Janz M, Jundt F, Hirsch B, Johrens Leder K, Vornlocher HP, Bommert K, Stein H, Dörken B: C FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor induced apoptosis. J. Exp. Med. 199, 1041-1052 (2004)

Henn V, Edemir B, Stefan E, Wiesner B, Lorenz D, Theilig F, Schmitt R, Vossebein L, Tamma G, Beyermann M, Krause E, Herberg FW, Valenti G, Bachmann S, Rosenthal W, Klussmann E: Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin 2 shuttle in renal principal cells. J. Bio. Chem. 279, 26654-26665 (2004)

Wüller S, Wiesner B, Löffler A, Furkert J, Krause G, Hermosilla R, Schaefer M, Schülein R, Rosenthal W, Oksche A: Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors. J. Bio. Chem. 279, 47254-47263 (2004)

2003

Siems WE, Maul B, Wiesner B, Becker M, Walther T, Rothe L, Winkler A: Effects of kinins on mammalian spermatozoa and the impact of peptidolytic enzeymes. Andrologica 35, 44-54 (2003)

Geissler D, Kresse W, Wiesner B, Bendig J, Kettenmann H, Hagen V: DMACM-Caged Adenosine Nucleotides: Ultrafast Phototriggers for ATP, ADP, and AMP Activated by Long-Wavelength Irradiation. ChemBioChem 4, 162-70 (2003)

Wiesner B, Roloff B, Fechner K, Slominski A: Intracellular calcium measurements of single human skin cells after stimulation with corticotropin-releasing factor and urocortin using confocal laser scanning microscopy. J. Cell Sci. 116, 1261-1268 (2003)

Hagen V, Frings S, Wiesner B, Helm S, Kaupp UB, Bendig J: [7 (Dialkylamino)coumarin 4 yl]methyl-caged compounds as ultrafast and effective long-wavelength phototriggers of 8 Bromo-stubstituted cyclic nucleotides. ChemBioChem 4, 434-442 (2003)

Meyer T, Marg A, Lemke P, Wiesner B, Vinkemeier U: DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1. Genes Dev. 17, 1992-2005 (2003)

Tamma G, Wiesner B, Furkert J, Hahm D, Oksche A, Schaefer M, Valenti G, Rosenthal W, Klussmann E: The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho. J. Cell Sci. 116, 3285-3294 (2003)

Kamp G, Büsselmann G, Jones N, Wiesner B, Lauterwein J: Energy metabolism and intracellular pH in boar (Sus scrofa) spermatozoa. Reproduction 126, 517-525 (2003)

Lorenz D, Krylov A, Hahm D, Hagen V, Rosenthal W, Pohl P, Maric K: Cyclic AMP is sufficient for triggering the exocytic recruitment of aquaporin-2 in renal epithelial cells. EMBO Rep. 4, 88-93 (2003)

2002

Wiesner B, Lorenz D, Krause E, Beyermann M, Bienert M: Measurement of intracellular fluorescence in the presence of a strong extracellular fluorescence using confocal laser scanning microscopy. LAMSO 3, 1-17 (2002)

Oehlke J, Birth P, Klauschenz E, Wiesner B, Beyermann M, Oksche A, Bienert M. Cellular uptake of antisense oligonucleotides after complexing or conjugation with cell-penetrating model peptides. Eur. J. Biochem. 269, 4025-4032 (2002)

Hagen V, Frings S, Bendig J, Lorenz D, Wiesner B, Kaupp UB: Fluoreszenzsprektroskopische Quantifizierung der Freisetzung von cyclischen Nucleotiden aus photoaktivierbaren [Bis(carboxymethoxy)-cumarin 4 yl]methylestern in Zellen. Angew. Chem. 114, 3775-3777 (2002)

Hagen V, Frings S, Bendig J, Lorenz D, Wiesner B, Kaupp UB: Fluorescence spectroscopic quantification of the release of cyclic nucleotides from photocleavable [Bis(carboxymethoxy)-cumarin 4 yl]methyl esters inside cells. Angew. Chem. Intern. Ed. 41, 3625-3628 (2002)

2001

Maric K, Wiesner B, Lorenz D, Klussmann E, Betz T, Rosenthal W: Cell volume kinetics of adherent epithelial cells measured by laser scanning reflection microscopy – determination of water permeability changes of renal principal cells. Biophys. J. 80, 1783-1790 (2001)

 Wiesner B, Müller K, Siems WE: Intracellular calcium measurements in single physilogical intact mammalian sperm cells using confocal laser scan microscopy. LAMSO 2, 1-10 (2001)

Klussmann E, Tamma G, Lorenz D, Wiesner B, Maric K, Hofmann F, Aktories K, Valenti G, Rosenthal W: An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin 2 into cell membranes of renal principal cells. J. Bio. Chem. 276, 20451-20457 (2001)

Schroeter ML, Müller S, Lindenau J, Wiesner B, Hanisch UK, Wolf G, Blasig IE. Astrocytes induce manganese superoxide dismutase in brain capillary endothelial cells. NeuroReport 12, 2513-2517 (2001)

2000

Scheller A, Wiesner B, Melzig M, Bienert M, Oehlke J: Evidence for an amphipathicity independent cellular uptake of amphipathic cell-penetrating peptides. Eur. J. Biochem. 267, 6043-6049 (2000)

1999

Klussmann E, Maric K, Wiesner B, Beyermann M and Rosenthal W: A-kinase anchoring proteins (AKAP’s) are required for vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells. J. Bio. Chem. 274, 4934-4938 (1999)

SchellerA, Oehlke J, Wiesner B, Dathe M, Krause E, Beyermann M, Melzig M and Bienert M: Structural requirements for cellular uptake of alpha helical amphipipathic peptides. J. Peptide Sci. 5, 185-194 (1999)

Wiesner B and Hagen V: Measurement of intracellular Ca2+ changes using novel caged cyclic nucleotides and confocal laser scanning microscopy. J. Photochem. Photobiol. 49, 112-119 (1999)

Klussmann E, Maric K, Wiesner B, Beyerman M, and Rosenthal W: Die Bedeutung der Verankerung der PKA für den Wasserhaushalt. BIOforum 22, 512-514 (1999)

Andersen Beckh B, Dehe M, Schülein R, Wiesner B, Rutz C, Liebenhoff U, Rosenthal W and Oksche A: Polarized expression of the vasopressin V2 receptor in Madin Darby canine kidney cells. Kidney Intern. 56, 517-527 (1999)

Hagen V, Bendig J, Frings S, Wiesner B, Schade B, Lorenz D, Kaupp UB: Synthesis, Photochemistry and Application of (7-methoxycoumarin-4-yl)-caged 8 bromoadenosine cyclic 3’,5’-monophosphate and 8 bromoguanosine cyclic 3’,5’-monophosphate photolyzed in the nanosecond time region. J. Photochem. Photobiol., 53, 91-102 (1999)

1998

Oksche A, Dehe, M, Schülein, R, Wiesner, B, Rosenthal W.: Folding and cell surface expression of the vasopressin V2 receptor: requirement of the intracellular C-terminus. FEBS Lett. 424, 57-62 (1998)

Wiesner, B, Weiner, J, Middendorff, R, Hagen, V, Kaupp, UB, Weyand I.: Cyclic nucleotide-gated channels on the flagellum control Ca2+ entry into sperm. J. Cell Biol. 142, 473-484 (1998)

Schülein R., Hermosilla R., Oksche A., Dehe M., Wiesner B, Krause G.; Rosenthal W.: A di-leucine sequence and an upstream glutamate residue in the intracellular C‑terminus of the vasopressin V2 receptor are essential for cell transport in transiently transfected COS.M6 cells. Mol. Pharmacol. 54, 525-535 (1998)

Oehlke J, Scheller A, Wiesner B, Krause E, Beyermann M, Klauschenz E, Melzig M, Bienert M: Cellular uptake of an a-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically. Biochim. Biophys. Acta 77472, 1-13 (1998)

Mertsch K, Grune T, Kunstmann S, Wiesner B., Ladhoff A, Siems WG, Haseloff R, Blasig IE: Protective effects of thiophosphate Amifostine (WR2721) and Lazaroid (U83836E) on lipid peroxidation in endothelial cells during hypoxia/reoxygenation-induced. Biochem. Pharm. 56, 945-954 (1998)

Lorenz L, Wiesner B, Zipper J, Winkler A, Krause E, Beyermann M, Lindau M, Bienert M: Mechanism of peptide-induced mast cell degranulation: Translocation and patch-clamp studies. J. Gen. Physiol. 112, 577-591 (1998)

Schülein R, Lorenz D, Oksche A, Wiesner B, Hermosilla R, Ebert J, Rosenthal W: Polarized cell surface expression of the green fluorescenct protein-tagged vasopressin V2 receptor in Madin Darby canine kidney cells. FEBS-Lett. 441, 170-176 (1998)

1997

Hagen V, Wiesner B, Bendig J, Kaupp UB: Photolabile (Coumarin-4-yl)methyl esters of 8-Bromo-cAMP and 8-Bromo-cGMP: Chemistry and application to CNG channels. FASEB, 11, 1415 (1997)

Oehlke J, Krause E, Wiesner B, Beyermann M, Bienert M: Extensive cellular uptake into endothelial cells of an amphipathic b-sheet forming peptide. FEBS Letters, 415, 196-199 (1997)

Oehlke J, Beyermann M, Wiesner B, Melzig M, Berger H, Krause E, Bienert M: Evidence for extensive and non-specific translocation of oligopeptides across plasma membranes of mammalian cells. Biochimica et Biophysica Acta, 1330, 50-60 (1997)

Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)
info(at)fmp-berlin.de

Like many sites, we use cookies to optimize the user's browsing experience. Data Protection OK