FMP Publications

Our publications are recorded in a searchable database since 2010, updates will be added regularly.

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References
Cerebral blood volume estimation by ferumoxytol-enhanced steady-state MRI at 9.4 T reveals microvascular impact of alpha1 -adrenergic receptor antibodies
Pohlmann(*), A., Karczewski(*), P., Ku(*), M. C., Dieringer(*), B., Waiczies(*), H., Wisbrun, N., Kox(*), S., Palatnik(*), I., Reimann(*), H. M., Eichhorn(*), C., Waiczies(*), S., Hempel(*), P., Lemke(*), B., Niendorf(*), T.; Bimmler(*), M.
Nmr Biomed, 27:1085-1093
(2014)

Tags: Animal Facility (Wiesbrun)

Abstract: Cerebrovascular abnormality is frequently accompanied by cognitive dysfunctions, such as dementia. Antibodies against the alpha1 -adrenoceptor (alpha1 -AR) can be found in patients with Alzheimer's disease with cerebrovascular disease, and have been shown to affect the larger vessels of the brain in rodents. However, the impact of alpha1 -AR antibodies on the cerebral vasculature remains unclear. In the present study, we established a neuroimaging method to measure the relative cerebral blood volume (rCBV) in small rodents with the ultimate goal to detect changes in blood vessel density and/or vessel size induced by alpha1 -AR antibodies. For this purpose, mapping of R2 * and R2 was performed using MRI at 9.4 T, before and after the injection of intravascular iron oxide particles (ferumoxytol). The change in the transverse relaxation rates (DeltaR2 *, DeltaR2 ) showed a significant rCBV decrease in the cerebrum, cortex and hippocampus of rats (except hippocampal DeltaR2 ), which was more pronounced for DeltaR2 * than for DeltaR2 . Immunohistological analyses confirmed that the alpha1 -AR antibody induced blood vessel deficiencies. Our findings support the hypothesis that alpha1 -AR antibodies lead to cerebral vessel damage throughout the brain, which can be monitored by MRI-derived rCBV, a non-invasive neuroimaging method. This demonstrates the value of rCBV estimation by ferumoxytol-enhanced MRI at 9.4 T, and further underlines the significance of this antibody in brain diseases involving vasculature impairments, such as dementia.

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Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)
info(at)fmp-berlin.de

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