FMP Publications

Our publications are recorded in a searchable database since 2010, updates will be added regularly.

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References
Dendronized Cryptophanes as Water-Soluble Xenon Hosts for Xe-129 Magnetic Resonance Imaging
Tyagi(*), R., Witte, C., Haag(*), R.; Schröder, L.
Org Lett, 16:4436-4439
(2014)

Tags: Molecular Imaging (Schröder)

Abstract: Cryptophane cages are very promising for Xe-129-MRI. These molecular cages are extremely hydrophobic, which currently limits their use for diagnostic applications. To overcome this, the synthesis of water-soluble dendronized cryptophanes with surface groups for further functionalization is reported here. These molecules retained all the "core properties of cryptophane" that are crucial for biosensor applications as analyzed by Hyper-CEST imaging and spectroscopy. This approach is promising for developing new generations of xenon-cryptophane-based biosensors.

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Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
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