FMP Publications

Our publications are recorded in a searchable database since 2010, updates will be added regularly.

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References
Real-time NMR monitoring of biological activities in complex physiological environments
Smith(*), M. J., Marshall(*), C. B., Theillet, F. X., Binolfi, A., Selenko, P.; Ikura(*), M.
Curr Opin Struct Biol, 32:39-47
(2015)

Tags: In-Cell NMR (Selenko)

Abstract: Biological reactions occur in a highly organized spatiotemporal context and with kinetics that are modulated by multiple environmental factors. To integrate these variables in our experimental investigations of 'native' biological activities, we require quantitative tools for time-resolved in situ analyses in physiologically relevant settings. Here, we outline the use of high-resolution NMR spectroscopy to directly observe biological reactions in complex environments and in real-time. Specifically, we discuss how real-time NMR (RT-NMR) methods have delineated insights into metabolic processes, post-translational protein modifications, activities of cellular GTPases and their regulators, as well as of protein folding events.

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Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
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13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)
info(at)fmp-berlin.de

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