FMP Publications

Our publications are recorded in a searchable database since 2010, updates will be added regularly.

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All :: 2014
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References
Proteome analysis of the HIV-1 Gag interactome
Engeland(*), C. E., Brown(*), N. P., Borner(*), K., Schümann, M., Krause, E., Kaderali(*), L., Müller(*), G. A.; Kräusslich(*), H. G.
Virology, 460-461:194-206
(2014)

Tags: Mass Spectrometry (Krause, E.)

Abstract: Human immunodeficiency virus Gag drives assembly of virions in infected cells and interacts with host factors which facilitate or restrict viral replication. Although several Gag-binding proteins have been characterized, understanding of virus-host interactions remains incomplete. In a series of six affinity purification screens, we have identified protein candidates for interaction with HIV-1 Gag. Proteins previously found in virions or identified in siRNA screens for host factors influencing HIV-1 replication were recovered. Helicases, translation factors, cytoskeletal and motor proteins, factors involved in RNA degradation and RNA interference were enriched in the interaction data. Cellular networks of cytoskeleton, SR proteins and tRNA synthetases were identified. Most prominently, components of cytoplasmic RNA transport granules were co-purified with Gag. This study provides a survey of known Gag-host interactions and identifies novel Gag binding candidates. These factors are associated with distinct molecular functions and cellular pathways relevant in host-pathogen interactions.

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Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
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