FMP Publications

Our publications are recorded in a searchable database since 2010, updates will be added regularly.

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References
Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions
Wu(*), Y. J., Tejero(*), R., Arancillo(*), M., Vardar(*), G., Korotkova, T., Kintscher(*), M., Schmitz(*), D., Ponomarenko, A., Tabares(*), L.; Rosenmund(*), C.
Journal of neurophysiology, 114:2404-2417
(2015)

Tags: Behavioral Neurodynamics (Korotkova/Ponomarenko)

Abstract: STX1 is a major neuronal syntaxin protein located at the plasma membrane of the neuronal tissues. Rodent STX1 has two highly similar paralogs, STX1A and STX1B, that are thought to be functionally redundant. Interestingly, some studies have shown that the distribution patterns of STX1A and STX1B at the central and peripheral nervous systems only partially overlapped, implying that there might be differential functions between these paralogs. In the current study, we generated an STX1B knockout (KO) mouse line and studied the impact of STX1B removal in neurons of several brain regions and the neuromuscular junction (NMJ). We found that either complete removal of STX1B or selective removal of it from forebrain excitatory neurons in mice caused premature death. Autaptic hippocampal and striatal cultures derived from STX1B KO mice still maintained efficient neurotransmission compared with neurons from STX1B wild-type and heterozygous mice. Interestingly, examining high-density cerebellar cultures revealed a decrease in the spontaneous GABAergic transmission frequency, which was most likely due to a lower number of neurons in the STX1B KO cultures, suggesting that STX1B is essential for neuronal survival in vitro. Moreover, our study also demonstrated that although STX1B is dispensable for the formation of the mouse NMJ, it is required to maintain the efficiency of neurotransmission at the nerve-muscle synapse.

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Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
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