Scientific Coordinator: Christian Hackenberger

Chemical Biology investigates the function of biological systems with the means of chemical synthesis. The research of this section focuses on the discovery, synthesis and use of chemical tools that can modulate specifically and selectively the function of target proteins. This work embraces peptides, proteins and low molecular weight drug-like molecules as well as the further development of protein analytics by mass spectroscopy. Biochemical and physical methods aid to investigate interactions of substances with important protein structures. Thereby we support a central goal of the institute which is the elucidation of new principles for pharmacological intervention with biological processes that may ultimately lead to new treatments of diseases.

Department Chemical Biology II (Christian Hackenberger)

Our group is interested in understanding how nature generates specific biological function in complex cellular environments. Research projects in our laboratory combine techniques and approaches from organic chemistry, biochemistry and biophysics with the major emphasis on synthetic methodology development for natural protein modifications.

Department Chemical Biology I (Dorothea Fiedler)

Our group seeks to develop a better understanding of the multiple ways in which nature utilizes phosphate in both protein signaling cascades and metabolic networks. Signaling and metabolic pathways are very complex, but the individual steps within these cascades depend on simple chemical reactions and often involve the reversible addition of phosphoryl groups. 

Structural Chemistry and Computational Biophysics (Han Sun)

Our group studies the structure of drug-like molecules and characterizes their interactions with proteins. We apply a variety of experimental and computational methods including NMR spectroscopy and molecular dynamics simulations.


Medicinal Chemistry (Marc Nazaré)

Our group is focused on developing new chemical tools to answer fundamental biological questions. These tools cover a broad range of applications from modulation of protein-ligand and protein-protein interactions to structure-activity relationship studies.  The application of these tools in in vitro and in vivo systems provides a deeper understanding of signal transduction pathways, molecular recognition phenomena of particular drug targets and other cellular events.

Junior Research Group: ChemBioProbes (Johannes Broichhagen)

Our lab is looking for new ways to visualize and interrogate biological function, such as cell signalling or protein dynamics.



Core Facility: Screening-Unit (Jens-Peter von Kries)

The Screening Unit provides a high throughput technology platform for screening compound libraries (about 60.000 cpds) and for genome-wide RNA-interference using automated microscopes or other methods. The unit manages the ChemBioNet screening collection (20.000 cpds) shared with partnering platforms within Europe.

Core Facility: Compound Management (Edgar Specker)
The aim of the Core Facility Compound Mangement is the production of screening plates for the primary screening at the Screening Unit, the preparation of hitpicking plates in order to conduct concentration-dependent validations of primary hits, the QC-controls of these hits and the support of users to prioritize their hit lists. 

Core Facility: Peptide Chemistry (Christian Hackenberger)

The core facility aims at providing simple synthetic peptides to FMP research groups.

Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)

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