Department Physiology and Pathology of Ion Transport (Thomas J. Jentsch)

                                                                      Reviews and Correspondences here

Selected original publications

(more complete list here)

Zhou C., Chen X., Planells-Cases R., Chu J., Wang L., Cao L., Li Z., López-Cayuqueo K.I., Xie Y., Ye S., Wang X., Ullrich F., Ma S., Fang Y., Zhang X., Qian Z., Liang X., Cai S., Jiang Z., Zhou D., Leng Q., Xiao T.S., Lan K., Yang J., Li H., Peng C., Qiu Z., Jentsch T.J., Xiao H. (2020).
Transfer of cGAMP into bystander cells by LRRC8 volume regulated anion channels augments STING-mediated interferon responses and antiviral immunity:
Immunity 52, 767-781
Pubmed  pdf  Suppl. Info   Perspective

Weinert S., Gimber N., Deuschel D., Stuhlmann T., Puchkov D., Farsi Z., Ludwig C.F., Novarino G., López-Cayuqueo K.I., Planells-Cases R., Jentsch T.J. (2020).
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
EMBO J. 39: e103358
Pubmed  pdf Expanded View  Appendix   News and Views

Göppner C., Orozco I.J., Hoegg-Beiler M.B., Soria A.H., Hübner C.A., Fernandes-Rosa F.L., Boulkroun S., Zennaro M.C., Jentsch T.J. (2019).
Pathogenesis of hypertension in a mouse model for CLCN2-related hyperaldosteronism.
Nature Comm., 10:4678.
Pubmed   pdf  Suppl. Info  Video1 Video 2 F1000  

Ullrich F., Blin S., Lazarow K., Daubitz T., von Kries J.P., Jentsch T.J. (2019).
Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels.
eLife 8:e49187.   DOI:
Pubmed   pdf

Zhou P., Polovitskaya M.M., Jentsch T.J. (2018).
LRRC8 amino-termini influence pore properties and gating of volume-regulated VRAC anion channels.
J. Biol. Chem. 293, 13440-13451.
Pubmed   pdf

Lück J.C., Puchkov D., Ullrich F., Jentsch T.J. (2018).
LRRC8/VRAC anion channels are required for late stages of spermatid development in mice.
J. Biol. Chem. 293, 11796-11808.
Pubmed    pdf

Stuhlmann T., Planells-Cases R., Jentsch T.J. (2018).
LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion.
Nature Comm. 9, 1974
Pubmed   pdf    Suppl. Info

Münch J., Billig G., Hübner C.A., Leinders-Zufall T., Zufall F., Jentsch T.J. (2018).
Ca2+-activated Cl- currents in the murine vomeronasal organ enhance neuronal spiking but are dispensable for male-male aggression.
J. Biol. Chem. 293, 10392-10403.
Pubmed   pdf   Suppl. Info

Fernandes-Rosa F.L., Daniil G., Orozco I.J., Göppner C., El Zein R., Jain V., Boulkroun S., Jeunemaitre X., Amar L., Lefebvre H., Schwarzmayr T., Strom T.M., Jentsch T.J., Zennaro M.C. (2018).
A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism.
Nature Genetics 50, 355-361.
Pubmed  pdf  Suppl. Info  Research Highlight Nature Rev Nephrol   F1000

Oberheide K. Puchkov D., Jentsch T.J. (2017).
Loss of the Na+/H+ exchanger NHE8 causes male infertility by disrupting acrosome formation.
J. Biol. Chem.  292, 10845-10854.
Pubmed    pdf

Lutter D., Ullrich F., Lueck J.C., Kempa S., Jentsch T.J. (2017).
Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.
J. Cell Sci. 130, 1122-1133.
Pubmed   pdf incl. Suppl. Info

Gödde K., Gschwend O., Puchkov D., Pfeffer C.K., Carleton A., Jentsch T.J. (2016).
Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination.
Nature Comm. 7, 12043
Pubmed     pdf    Suppl. Info  Faculty 1000

Ullrich F., Reincke S.M., Voss F.K., Stauber T., Jentsch T.J. (2016).
Inactivation and anion selectivity of volume-regulated VRAC channels depend on carboxy-terminal residues of the first extracellular loop.
J. Biol. Chem., 291, 17040-17048.
Pubmed    pdf

Schütze S., Orozco I.J., Jentsch T.J. (2016).
KCNQ potassium channels modulate sensitivity of skin D-hair mechanoreceptors.
J. Biol. Chem. 291, 5566-5575.
Pubmed   pdf

Planells-Cases R., Lutter D., Guyader C., Gerhards N.M., Ullrich F., Elger D.A., Kucukosmanoglu A, Xu G., Voss F.K., Reincke S.M., Stauber T., Blomen V.A., Vis D.J., Wessels L.F., Brummelkamp T.R., Borst P., Rottenberg S., Jentsch T.J. (2015).
VRAC channel composition determines its substrate specificity and cellular resistance to Pt-based anti-cancer drugs.
EMBO J. 34, 2993-3008.
Pubmed  pdf   Expanded View   Appendix  merged pdf  News and Views

Rost B.R., Schneider F., Grauel M.K., Wozny C., Bentz C.G., Blessing A., Rosenmund T., Jentsch T.J., Schmitz D., Hegemann P., Rosenmund C. (2015).
Optogenetic acidification of synaptic vesicles and lysosomes.
Nature Neurosci. 18, 1845-1852.
Pubmed   pdf

Fidzinski P., Korotkova T.,  Heidenreich M., Maier N., Schuetze S., Kobler O., Zuschratter W., Schmitz D., Ponomarenko A., Jentsch T.J. (2015).
KCNQ5 K+ channels control hippocampal synaptic inhibition and fast network oscillations.
Nature Commun. 6, 6254 DOI: 10.1038/ncomms7254
Pubmed    pdf  Suppl. Info

Weinert S., Jabs S., Hohensee S., Chan W.L., Kornak U., Jentsch T.J. (2014).
Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions.
EMBO Rep. 15, 784-791.
Pubmed   pdf   Suppl. Info

Voss F.K., Ullrich F., Münch J., Lazarow K., Lutter D., Mah N., Andrade-Navarro M.A., von Kries J.P., Stauber T., Jentsch T.J. (2014).
Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.
Science  244, 634-638. (published as Express on April 10)
Pubmed    pdf   Suppl. Info   merged pdf    Highlight (Nature Rev Cell Mol Biol) 

Hoegg-Beiler M.B., Sirisi S., Orozco I.J., Ferrer I., Hohensee S., Auberson M., Gödde K., Vilches C., López de Heredia M., Nunes V., Estévez R., Jentsch T.J. (2014).
Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction.
Nature Commun. 5: 3475 doi: 10.1038/ncomms4475.
Pubmed   pdf

Ludwig C.F., Ullrich F., Leisle L., Stauber T., Jentsch T.J. (2013).
Common gating of both CLC transporter subunits underlies voltage-dependent activation of the 2Cl-/1H+-exchanger ClC-7/Ostm1.
J. Biol. Chem. 288, 28611-28619.
Pubmed   pdf

Spitzmaul G., Tolosa L., Winkelman B.H.J., Heidenreich M., Frens M.A., Chabbert C., de Zeeuw C.I., Jentsch T.J. (2013).
Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models.
J. Biol. Chem. 288, 9334-9344.
Pubmed      pdf      Suppl. Info

Jeworutzky E., López-Hernández, T., Capdevila-Nortes X., Sirisi S., Bengtsson L., Montolio M., Zifarelli G., Müller C.S., Schulte U., Nunes V., Martínez A., Jentsch T.J., Gasull X., Pusch M., Estévez R. (2012).
GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl- channel auxilliary subunit.
Neuron 73, 951-961.
Pubmed   pdf   Suppl. Info  Perspective

Seja P., Schonewille M., Spitzmaul G., Badura A., Klein I., Rudhard Y., Wisden W., Hübner C.A., de Zeuw C.I., Jentsch T.J. (2012).
Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning.
EMBO J. 31,1217-1230.
Pubmed   pdf  Suppl. Info.  

Heidenreich M., Lechner S.G., Vardanyan V., Wetzel C., Cremers C.W., De Lenheer E.M., Aránguez G., Moreno-Pelayo M.A., Jentsch T.J., Lewin G.R. (2012).
KCNQ4 K+channels tune mechanoreceptors for normal touch sensation in mouse and man.
Nature Neurosci.15, 138-145.
Pubmed   pdf   Suppl. Info   Suppl. Video   News & Views   News comment

Billig G.M., Pál B., Fidzinski P., Jentsch T.J. (2011).
Ca2+-activated Cl- currents are dispensable for olfaction.
Nature Neurosci 14, 763-749.
Pubmed   pdf   Suppl. Info   

Leisle L., Ludwig C.F., Wagner, F.A., Jentsch, T.J., Stauber T. (2011).
ClC-7 is a slowly voltage-gated 2Cl-/H+ exchanger and requires Ostm1 for transport activity.
EMBO J. 30, 2140-2152.
Pubmed   pdf   Supplementary Info (pdf)  Suppl Video

Stauber T., Jentsch T.J. (2010).
Sorting motifs in the endosomal/lysosomal CLC chloride transporters.
J. Biol. Chem. 285, 34537-34548.
Pubmed  pdf   Supplementary Info (pdf)

Steinberg B.E., Huynh K.K., Brodovitch A., Jabs S., Stauber T., Jentsch T.J., Grinstein S. (2010).
A cation counterflux supports lysosomal acidification.
J. Cell Biol. 189, 1171-1186.
Pubmed   pdf   Supplementary Info (pdf)   Highlight

Weinert S., Jabs S., Supanchart C., Schweizer M., Gimber N., Richter M., Rademann J., Stauber T., Kornak U., Jentsch T.J. (2010).
Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation.
Science 328, 1401-1403.   
Pubmed   pdf  Supplementary Info (pdf)  Perspective

Novarino G., Weinert S., Rickheit G., Jentsch T.J. (2010).
Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis.
Science 328, 1398-1401.
Pubmed   pdf   Supplementary Info (pdf)   Perspective in Science  Comment in NDT

Neagoe I., Stauber T., Fidzinski P., Bergsdorf E.-Y., Jentsch T.J. (2010).
The late endosomal ClC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression.
J. Biol. Chem. 285, 21689-21697.
Pubmed  pdf   Supplementary Info (pdf)

Tzingounis A.V., Heidenreich M., Kharkovets T., Spitzmaul G., Jensen H.S., Nicoll R.A., Jentsch T.J. (2010).
The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus.
Proc. Natl. Acad. Sci USA 107, 10232-10237.
Pubmed   pdf   Supplementary Info (pdf)

Rickheit G., Wartosch L., Schaffer S., Stobrawa S.M., Novarino G., Weinert S., Jentsch, T.J. (2010).
Role of ClC-5 in renal endocytosis is unique among CLC exchangers and does not require PY-motif-dependent ubiquitylation.
J. Biol Chem. 285, 17595-17603.
Pubmed   pdf   Supplementary Info (pdf)

Preston P., Wartosch L., Günzel D., Fromm M., Kongsuphol P., Ousingsawat J., Kunzelmann K., Barhanin J., Warth R., Jentsch, T.J. (2010).
Disruption of the K+ channel β-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport.
J. Biol Chem. 285, 7165-7175.
Pubmed   pdf   Supplementary Info (pdf)

Wartosch L., Fuhrmann J.C., Schweizer M., Stauber T., Jentsch T.J. (2009).
Lysosomal degradation of endocytosed protein depends on the chloride transport protein ClC-7.
FASEB J. 23, 4056-4068.
Pubmed   pdf   Supplementary Info (pdf)

Bergsdorf E-Y, Zdebik A.A., Jentsch T.J. (2009).
Residues important for nitrate/proton coupling in plant and mammalian CLC transporters.
J. Biol. Chem. 284, 11184-11193. 
Pubmed   pdf

Pfeffer C.K., Stein V., Keating D.J., Maier H., Rinke I., Rudhard Y., Hentschke M., Rune G., Jentsch T.J., Hübner C.A. (2009).
NKCC1-dependent GABArgic excitation drives synpatic network maturation during early hippocampal development.
J. Neurosci. 29, 3419-3430.
Pubmed   pdf   Supplementary Info (pdf)

Rickheit G., Maier H., Strenzke N., Andreescu C.E., De Zeeuw C.I., Zdebik A.A., Jentsch T.J. (2008).
Endocochlear potential depends on Cl- channels: mechanism underlying deafness in Bartter syndrome IV.
EMBO J. 27, 2907-2917.
Pubmed   pdf   Supplementary Info (pdf)   OMIM

Maritzen T., Keating D.J., Neagoe I., Zdebik A.A., Jentsch T.J. (2008).
Role of the vesicular chloride transporter ClC-3 in neuroendocrine tissue.
J. Neurosci. 28, 10587-10598 
Pubmed   pdf    Supplementary Info (pdf)
Zdebik A.A., Zifarelli G., Bergsdorf E.-Y., Soliani P., Scheel O., Jentsch T.J., Pusch M. (2008).
Determinants of anion-proton coupling in mammalian endosomal CLC proteins.
J. Biol. Chem. 283, 4219-4227.
Pubmed   pdf   Supplementary Info (pdf)

Blanz J., Schweizer M., Auberson M., Maier H., Muenscher A., Hübner C.A.,  Jentsch T.J. (2007).
Leukoencephalopathy upon disruption of the chloride channel ClC-2.
J. Neurosci. 27, 6581-6589.
Pubmed   pdf   Supplementary Info (pdf)   

Rust M.B., Alper S.L., Rudhard Y., Shmukler B.E., Vicente R., Brugnara C.,  Trudel M.,  Jentsch T.J., Hübner C.A. (2007).
Disruption of erythroid KCl-cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.
J. Clin. Invest. 117, 1708-1717.
Pubmed   pdf   Supplementary Info (pdf)   

Poët M., Kornak U., Schweizer M., Zdebik A.A., Scheel O., Hoelter S., Wurst W., Schmitt A., Fuhrmann J.C., Planells-Cases R., Mole S.E., Hübner C.A., Jentsch T.J. (2006).
Lysosomal storage disease upon disruption of the neuronal chloride transport protein ClC-6.
Proc. Natl. Acad. Sci. U S A. 103, 13854-13859.
Pubmed   pdf

Lange P.F., Wartosch L., Jentsch T.J., Fuhrmann J.C. (2006).
ClC-7 requires Ostm1 as a β-subunit to support bone resorption and lysosomal function.
Nature  440, 220-223.
Pubmed   pdf   Supplementary Info (pdf)  OMIM

Kharkovets T., Dedek K., Maier H., Schweizer M., Khimich D., Nouvian R., Vardanyan V., Leuwer R., Moser T., Jentsch T.J. (2006).
Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness.
EMBO J.  25, 642-652.
Pubmed   pdf   Supplementary Info (pdf)  OMIM

Rust M.B., Faulhaber J., Budack M.K.,   Pfeffer C., Maritzen T., Didié M., Beck F.X., Boettger T., Schubert R., Ehmke H., Jentsch T.J., Hübner C.A. (2006).
Neurogenic mechanisms contribute to hypertension in mice with disruption of the K-Cl cotransporter KCC3.
Circ. Res. 98 , 549-556.
Pubmed   pdf

Scheel O., Zdebik A.A., Lourdel S., Jentsch T.J. (2005).
Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins.
Nature 436, 424-427.
Pubmed   pdf

Schenzer A., Friedrich T., Pusch M., Saftig P, Jentsch T.J., Grötzinger J., Schwake M. (2005).
Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.
J. Neurosci. 25, 5051-5060.
Pubmed   pdf

Kasper D., Planells-Cases R., Fuhrmann J.C., Scheel O., Zeitz O., Ruether K., Schmitt A., Poët M., Steinfeld R., Schweizer M., Kornak U., Jentsch T.J. (2005).
Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration.
EMBO J.  24, 1079-1091.
Pubmed   pdf   Supplementary Info (pdf)  OMIM

Zdebik A.A., Cuffe J., Bertog M., Korbmacher C., Jentsch T.J. (2004).
Additional disruption of the ClC-2 Cl- channel does not exacerbate the cystic fibrosis phenotype of CFTR mouse models.
J. Biol. Chem. 279,  22276-22283.
Pubmed   pdf

Estévez R., Pusch M., Ferrer-Costa C., Orozco M., Jentsch T.J. (2004).
Functional and structural conservation of CBS domains from CLC chloride channels.
J. Physiol. 557.2, 363-378.
Pubmed   pdf

Boettger T., Rust M.B., Maier H., Seidenbecher T., Schweizer M., Keating D., Faulhaber J., Ehmke H., Pfeffer C., Scheel O., Lemcke B., Host J., Leuwer R., Pape H.C., Völkl H., Hübner C.A., Jentsch T.J. (2003).
Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold.
EMBO J. 22, 5422-5434.
Pubmed   pdf   Supplementary Info (pdf)

Estévez R., Schroeder B.C., Accardi A., Jentsch T.J., Pusch M. (2003).
Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1.
Neuron 38, 47-59.
Pubmed   pdf   Neuron Preview (pdf)

Schwake M., Jentsch T.J., Friedrich T. (2003).
A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly.
EMBO Rep.  4, 76-81.
Pubmed   pdf

Boettger T., Hübner C.A., Maier H., Rust M.B., Beck F.X., Jentsch T.J. (2002).
Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter KCC4.
Nature  416, 874-878.
Pubmed   pdf   Supplementary Info (pdf)

Estévez R., Boettger T., Stein V., Birkenhäger R., Otto E., Hildebrandt F., Jentsch T.J. (2001).
Barttin is a Cl- channel ß-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion.
Nature  414, 558-561.
Pubmed   pdf   News and Views  OMIM   Supplementary Info (pdf)

Dedek K., Kunath B., Kananura C., Reuner U., Jentsch T.J., Steinlein O. (2001)
Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel.
Proc. Natl. Acad. Sci. U.S.A. 98, 12272-12277.
Pubmed   pdf  OMIM

Betz R.C., Schoser B.G., Kasper D., Ricker K., Ramírez A., Stein V., Torbergsen T., Lee Y.A., Nothen M.M., Wienker T.F., Malin J.P., Propping P.,  Reis A., Mortier W., Jentsch T.J., Vorgerd M., Kubisch C. (2001)
Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease.
Nature Genet. 28, 218-219.
Pubmed   pdfOMIM

Hübner C.A., Stein V., Hermans-Borgmeyer I., Meyer T., Ballanyi K., Jentsch T.J. (2001)
Disruption of KCC2 reveals an essential role of K-Cl-cotransport already in early synaptic inhibition.
Neuron 30, 515-524.
Pubmed   pdf

Bösl M.R., Stein V., Hübner C., Zdebik A.A., Jordt S.E., Mukhophadhay A.K.,  Davidoff M.S., Holstein A.F., Jentsch T.J. (2001)
Male germ cells and photoreceptors, both depending on close cell-cell interactions, degenerate upon ClC-2 Cl--channel disruption.
EMBO J. 20, 1289-1299.
Pubmed   pdf

Kornak U., Kasper D., Bösl M.R., Kaiser E., Schweizer M., Schulz A., Friedrich W., Delling G., Jentsch T.J. (2001)
Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man.
Cell 104, 205-215.
Pubmed   pdf  Nature News & Views  OMIM

Stobrawa S.M., Breiderhoff T., Takamori S., Engel D., Schweizer M., Zdebik A.A., Bösl M.R., Ruether K., Jahn H., Draguhn A., Jahn R., Jentsch T.J. (2001)
Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus.
Neuron 29, 185-196.
Pubmed   pdf   Neuron Preview  Nature Rev Neurosci Highlight

Schwake M., Friedrich T., Jentsch T.J. (2001)
An internalization signal in ClC-5, an endosomal Cl--channel mutated in Dent's disease.
J. Biol. Chem. 276, 12049-12054.
Pubmed   pdf

Weinreich F., Jentsch T.J. (2001)
Pores formed by single subunits in mixed dimers of different CLC chloride channels.
J. Biol. Chem. 276,  2347-2353.
Pubmed   pdf

Piwon N., Günther W., Schwake M., Bösl M.R., Jentsch T.J. (2000)
ClC-5 Cl--channel disruption impairs endocytosis in a mouse model for Dent's disease.
Nature 408, 369-373.
Pubmed   pdf   Supplementary Info   OMIM  

Kornak U., Schulz A., Friedrich W., Uhlhaas S., Kremens B., Voit T., Hasan C., Bode U., Jentsch T.J., Kubisch C. (2000)
Mutations in the a3 subunit of the vacuolar H+-ATPase cause infantile malignant osteopetrosis.
Hum. Mol. Genet. 13, 2059-2063.
Pubmed   pdf  OMIM

Waldegger S., Jentsch T.J. (2000)
Functional and Structural Analysis of ClC-K Chloride Channels Involved in Renal Disease.
J. Biol. Chem. 275, 24257-24533.
Pubmed   pdf

Schroeder B.C., Hechenberger M., Weinreich F., Kubisch C.,  Jentsch T.J. (2000)
KCNQ5, a Novel Potassium Channel Broadly Expressed in Brain, Mediates M-type Currents.
J. Biol. Chem. 275, 24089-24095.
Pubmed   pdf

Kharkovets T., Hardelin J.-P., Safieddine S., Schweizer M., El-Amraoui A., Petit C., Jentsch T.J. (2000)
KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway.
Proc. Natl. Acad. Sci. U.S.A. 97, 4333-4338.
Pubmed   pdf   Commentary

Schroeder B.C., Waldegger S., Fehr S., Bleich M., Warth R., Greger R., Jentsch T.J. (2000)
A constitutively open potassium channel formed by KCNQ1 and KCNE3.
Nature 403, 196-199.
Pubmed   pdf    Suppl. Info    Comment in TIPS  

Schriever A.M., Friedrich T., Pusch M., Jentsch T.J. (1999)
CLC chloride channels in Caenorhabditis elegans.
J. Biol. Chem. 274, 34238-34244.
Pubmed   pdf

Kubisch C., Schroeder B.C., Friedrich T., Lütjohann B., El-Amraoui A., Marlin S., Petit C., Jentsch T.J. (1999)
KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness.
Cell 96, 437-446.
Pubmed   pdf   OMIM    

Friedrich T., Breiderhoff T., Jentsch T.J. (1999)
Mutational analysis demonstrates that ClC-4 and ClC-5 directly mediate plasma membrane currents.
J. Biol. Chem. 274, 896-902.
Pubmed   pdf
Schroeder B. C., Kubisch C., Stein V., Jentsch T. J. (1998)
Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy.
Nature 396, 687-690.
Pubmed   pdf

Günther W., Lüchow A., Cluzeaud F., Vandewalle A., Jentsch T.J. (1998)
ClC-5, the chloride channel mutated in Dent's disease, co-localizes with the proton pump in endocytotically active kidney cells.
Proc. Natl. Acad. Sci. U.S.A. 95,8075-8080.
Pubmed   pdf  Commentary   

Schwappach B., Stobrawa S., Hechenberger M., Steinmeyer K., Jentsch T.J. (1998)
Golgi localization and functionally important domains in the NH2 and COOH terminus of the yeast ClC putative chloride channel Gef1p.
J. Biol. Chem. 274, 15110-15118.
Pubmed   pdf

Biervert C., Schroeder B.C., Kubisch C., Berkovic S.F., Propping P., Jentsch T.J., Steinlein O.K. (1998)
A potassium channel mutation in neonatal human epilepsy.
Science 279, 403-406.
Pubmed   pdf   OMIM

Jordt S.E.,  Jentsch T.J. (1997).
Molecular dissection of gating in the ClC-2 chloride channel.
EMBO J. 16, 1582-1592.
Pubmed   pdf

Schmidt-Rose T., Jentsch T.J. (1997).
Transmembrane topology of a ClC chloride channel.
Proc. Natl. Acad. Sci. U.S.A. 94, 7633-7638.
Pubmed   pdf

Ludewig U., Pusch M., Jentsch T.J. (1996).
Two physically distinct pores in the dimeric ClC-0 chloride channel.
Nature 383, 340-343.
Pubmed   pdf    News and Views

Hechenberger M., Schwappach B., Fischer W.N., Frommer W.B., Jentsch T.J., Steinmeyer K. (1996).
A family of putative chloride channels from Arabidopsis and functional complementation of a yeast strain with a ClC gene disruption.
J. Biol. Chem. 271, 33632-33638.
Pubmed   pdf

Lloyd S.E., Pearce S.H.S., Fisher S.E., Steinmeyer K., Schwappach B., Scheinman S.S., Harding B., Bolino M., Devoto M., Goodyer P., Rigden S.P.A., Wrong O., Jentsch T.J., Craig I.W., Thakker R.V. (1996).
A common molecular basis for three inherited kidney stone diseases.
Nature 379, 445-449.
Pubmed   pdf    News and ViewsOMIM

Lorenz C., Pusch M.,  Jentsch T.J. (1996).
Heteromultimeric ClC chloride channels with novel properties.
Proc. Natl. Acad. Sci. U.S.A. 93, 13362-13366.
Pubmed   pdf

Pusch M., Steinmeyer K., Koch M.C.,  Jentsch T.J. (1995).
Mutations in dominant human myotonia congenita drastically alter the voltage-dependence of the ClC-1 chloride channel.
Neuron 15, 1455-1463.
Pubmed   pdf

Pusch M., Ludewig U., Rehfeldt A.,  Jentsch T.J. (1995).
Gating of the voltage-dependent chloride channel ClC-0 by the permeant anion.
Nature 373, 527-531.
Pubmed   pdf

Steinmeyer K., Schwappach B., Bens M., Vandewalle A.,  Jentsch T.J. (1995).
Cloning and functional expression of rat ClC-5, a chloride channel related to kidney disease.
J. Biol. Chem. 270, 31172-31177.
Pubmed   pdf

Kieferle S., Fong P., Bens M., Vandewalle A.,  Jentsch T.J. (1994).
Two highly homologous members of the ClC chloride channel family in both rat and human kidney.
Proc. Natl. Acad. Sci. U.S.A. 91, 6943-6947.
Pubmed   pdf

Steinmeyer K., Lorenz C., Pusch M., Koch M.C., Jentsch T.J. (1994).
Multimeric structure of ClC-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen).
EMBO J. 13, 737-743.
Pubmed   pdf

Gründer S., Thiemann A., Pusch M.,  Jentsch T.J. (1992).
Regions involved in the opening of ClC-2 chloride channel by voltage and cell volume.
Nature 360, 759-762.
Pubmed   pdf

Koch M.C., Steinmeyer K., Lorenz C., Ricker K., Wolf F., Otto M., Zoll B., Lehmann-Horn F., Grzeschik K.H., Jentsch T.J. (1992).
The skeletal muscle chloride channel in dominant and recessive human myotonia.
Science 257, 797-800.
Pubmed   pdf

Thiemann A., Gründer S., Pusch M.,  Jentsch T.J. (1992).
A chloride channel widely expressed in epithelial and non-epithelial cells.
Nature 356, 57-60.
Pubmed   pdf

Bauer C.K., Steinmeyer K., Schwarz J.R.,  Jentsch T.J. (1991).
Completely functional double-barreled chloride channel expressed from a single Torpedo cDNA.
Proc. Natl. Acad. Sci. U.S.A. 88, 11052-11056.
Pubmed   pdf

Steinmeyer K., Klocke R., Ortland C., Gronemeier M., Jockusch H., Gründer S.,  Jentsch T.J. (1991).
Inactivation of muscle chloride channel by transposon insertion in myotonic mice.
Nature 354, 304-308.
Pubmed   pdf

Steinmeyer K., Ortland C.,  Jentsch T.J. (1991).
Primary structure and functional expression of a developmentally regulated skeletal muscle chloride channel.
Nature 354, 301-304.
Pubmed   pdf

Jentsch T.J., Steinmeyer K.,  Schwarz, G. (1990).
Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes.
Nature 348, 510-514.
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Jentsch T.J., Garcia A.M.,  Lodish H.F. (1989).
Primary structure of a novel 4-acetamido-4'- isothiocyanostilbene-2,2'-disulphonic acid (SITS)-binding membrane protein highly expressed in Torpedo electroplax.
Biochem. J. 261, 155-166.
Pubmed   pdf

Jentsch T.J., Janicke I., Sorgenfrei D., Keller S.K.,  Wiederholt M. (1986).
The regulation of intracellular pH in monkey kidney epithelial cells (BSC-1). Role of Na+/H+-antiport, Na+-HCO3-(NaCO3-) symport, and Cl-/HCO3- exchange.
J. Biol. Chem. 261, 12120-12127.
Pubmed   pdf

Jentsch T.J., Keller S.K., Koch M.,  Wiederholt M. (1984).
Evidence for coupled transport of bicarbonate and sodium in cultured bovine corneal endothelial cells.
J. Membrane Biol. 81, 189-204.
Pubmed   pdf

Ernst N., Jentsch T. (1981).
Post-field ionization of singly charged rhodium: An experimental and theoretical study.
Phys. Rev. B 24, 6234-6240.


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