News
01/2021 A short research talk on our recently published paper in Neuron in which we discovered a surprising role for autophagy in neurons here
https://we.tl/t-vW7qxaRbDy
11/2020 Postdoctoral and PhD Student Positions in Neuroscience and Cell Biology availabele! Please submit your complete application in electronic form via e-mail to Haucke(at)fmp-berlin.de
11/2020 Marijn’s paper on the role of neuronal autophagy in regulating neurotransmission by controlling the axonal endoplasmic reticulum is out, in Neuron since 5 November! Congrats to Marijn and her co-authors!
https://www.cell.com/neuron/fulltext/S0896-6273(20)30773-X
10/2020 Congrats to Sila and Dorien on publishing their review entitled “A presynaptic perspective on transport and assembly mechanisms for synapse formation” in Neuron!
https://www.cell.com/neuron/fulltext/S0896-6273(20)30762-5
05/2020 Linda’s paper on “Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth” is now online at Nature Communications. Congrats to Linda and her collaborators for all the hard work to complete this study that may also offer first treatment options for CMT patients!
05/2020 Tania’s paper on “"Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis" is accepted in Nature Cell Biology. Congrats to Tania!
04/2020 Feldberg Prize Lecture Volker Haucke at LMB Cambridge, UK
01/2020 Haibin's paper appeared advance online in JBC! See:Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway.
01/2020 Marta's new paper on Spermidine in Brain Aging is out!!Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses.
01/2020 Maria´s paper on the role of intersection in release site clearance now published in Cell Reports
11/2019 Martin´s paper on FCHo2 control on clathrin-coated pit growth and stability now published in Science Advances
09/2019 Alex´ and Phillip´s study on the regulation of PI3KC2beta during nutrient signaling now out in Nature Cell Biology
Department Molecular Pharmacology and Cell Biology (Volker Haucke)
Welcome to the Volker Haucke department!
In the Haucke laboratory we aim to understand how cellular membranes and membrane-enclosed compartments dynamically exchange materials between them and its implications for cell signaling in health and disease. Our main focus is on the endocytic and endolysosomal system that we study in genome-engineered cell lines and in nerve cells or tissue. The laboratory uses a broad range of techniques including biochemical and molecular biology approaches, super-resolution light and electron microscopy, chemical biology and screening technology, electrophysiology as well as genetic and genome engineering at the cellular or organismic levels in vivo.
The overarching goal of these studies is to provide a mechanistic understanding of the assembly of protein-lipid scaffolds that support exo-endocytosis coupling and endolysosomal functions, and to use this know-how to develop novel strategies for pharmacological or genetic interference. Our studies thereby provide important and novel insights into the molecular mechanisms underlying a broad range of diseases, including epilepsy, neurodegeneration, lysosomal disorders, myopathies and cancer.
Research within the Haucke lab can be grossly divided into two major topics:
(1) The formation and maintenance of the presynaptic compartment and its role in synaptic neurotransmission, and
Head
Prof. Dr. Volker Haucke
CV Volker Haucke
How to become a Haucke lab member
We always seek interested and highly motivated postdocs and master or PhD students! Please apply directly by sending an email including your CV and a letter of motivation to haucke(at)fmp-berlin.de.
Current vacancies include:
- 11/2020 Postdoctoral and PhD Student Positions in Neuroscience and Cell Biology available! Please submit your complete application in electronic form via e-mail to Haucke(at)fmp-berlin.de
Video presentation of the lab's research focus: Volker Haucke explaining endosomal recycling
Video portrait of the department (in German only)
Video presentation of the Marie Skłodowska-Curie Innovative Training Network: Phd - PI3K biology in health and disease
The Department also hosts the research group of
Prof. Dr. Michael Krauß
Small GTPases in Membrane Traffic
Read more about the Krauß Lab here!
