Andrew Plested
Heisenberg Professor of Cellular Biophysics, Humboldt Universität zu Berlin
plested [at]

Lab Address (Buch):
Leibniz-Forschungsinstitut für Molekulare Pharmakologie
Room A206
Robert-Rössle-Straße 10
D-13125 Berlin
Tel.: +49 (0) 30 94793-245
                                   -322 (Lab)

Office Address (Mitte):
Humboldt Universität zu Berlin
Institute of Biology, Cellular Biophysics
Invalidenstraße 42,
Mittelbau, Room 101
D-10115 Berlin
Tel: +49 (0) 30 2093 8493

Students seeking an appointment, please use HU Moodle.

We don't have a fax.

HiWi wanted!

The Plested lab is urgently seeking a HiWi to assist our molecular biology efforts. Please contact Andrew Plested or Marcus Wietstruk ( ) for more details about the position. Posted 200814

Molecular Neuroscience and Biophysics (Andrew Plested)

In the Plested lab, we are interested in ion channel receptors and fast signalling in the nervous system. Receptors that are found at synapses between nerve cells have formed the backbone of our research for some years. The activation of these complex macromolecular machines is triggered by neurotransmitters in a fraction of a second. Our objective is to understand the relationship between the molecular structure of a given receptor (its shape) and its activity (what it does). More recently, we have become interested in the relation between receptor properties and synaptic signalling. 

We are members of the Humboldt University Institute for Biology, the NeuroCure Cluster of Excellence, and the Leibniz-Institut für Molekulare Pharmakologie (FMP). Our laboratories are located in the Marthe-Vogt-Haus (Haus 81) at the Campus Berlin Buch. If you would like to contact us, please write to the email address on the right.

Latest News

6.7.20 Our last paper with lab legend Héctor Salazar is out, open access at Biophysical Journal. In this manuscript, Measurements of the Timescale and Conformational Space of AMPA receptor Desensitization, Hector crosslinked desensitizing receptors to count desensitized states and Sabrina Mischke made careful measurements of reovery to reveal these stable inactive states in wild-type GluA2. 

06.01.20 Our former collaborator, Benjamin König, has joined the lab for his postdoc. Benni joins us from Tobias Stauber's lab and will work on glutamate indicators and associated microscopes, funded by the NeuroCure Cluster of Excellence. Welcome back to Buch, Benni!

1.12.19 Katerina Salivara has joined us for a six-month Erasmus+ visit and will work with Niccolò on excitatory synapses. She is our first ever Greek lab member. Welcome to Berlin, Katerina!

18.06.19 "A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength" is online at eLife, a collaboration with Benni König and Tobias Stauber. Yuchen Hao from our lab did the patch clamp fluorimetry to understand VRAC activation.

18.06.19 "Gating modules of the AMPA receptor pore domain revealed by unnatural amino acid mutagenesis" is online at PNAS. Congrats to Mette, Anahita, Vicky and Vale for all the hard work to complete this survey of the AMPA receptor pore domain. 



Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)

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