Andrew Plested
Heisenberg Professor of Cellular Biophysics, Humboldt Universität zu Berlin
andrew.plested [at]

Lab Address (Buch):
Leibniz-Forschungsinstitut für Molekulare Pharmakologie
Room A206
Robert-Rössle-Straße 10
D-13125 Berlin
Tel.: +49 (0) 30 94793-245

Office Address (Mitte):
Humboldt Universität zu Berlin
Institute of Biology, Cellular Biophysics
Invalidenstraße 42,
Mittelbau, Room 109
D-10115 Berlin
Tel: +49 (0) 30 2093 8493

Students seeking an appointment, please use HU Moodle.

We don't have a fax.

HiWi wanted!

The Plested lab is urgently seeking a HiWi to assist our molecular biology efforts. Please contact Andrew Plested or Marcus Wietstruk ( ) for more details about the position. Posted 200814

Molecular Neuroscience and Biophysics (Andrew Plested)

In the Plested lab, we are interested in ion channel receptors and fast signalling in the nervous system. Receptors that are found at synapses between nerve cells have formed the backbone of our research for some years. The activation of these complex macromolecular machines is triggered by neurotransmitters in a fraction of a second. Our objective is to understand the relationship between the molecular structure of a given receptor (its shape) and its activity (what it does). More recently, we have become interested in the relation between receptor properties and synaptic signalling. 

We are members of the Humboldt University Institute for Biology, the NeuroCure Cluster of Excellence, and the Leibniz-Institut für Molekulare Pharmakologie (FMP). Our laboratories are located in the Marthe-Vogt-Haus (Haus 81) at the Campus Berlin Buch. If you would like to contact us, please write to the email address on the right.

Latest News

02.06.21 Two very interesting papers concerning hippocampal AMPA receptors have been published in Nature (from the Gouaux and Greger labs), and Andrew wrote the News and Views. Glutamate Receptor complexes open up and reveal their molecular dialect

31.03.21 Andrew co-authored a chapter for the legendary series "Methods in Enzymology" with former Plested lab member Mette Poulsen. Among the methods included are fast perfusion, unnatural amino acid mutagenesis and biochemical analysis of UV-driven crosslinking. Crosslinking Glutamate Receptor Ion Channels 

18.02.21 Johann's paper, Nonselective cation permation in an AMPA-type glutamate receptor is online! Congrats to both Johann and Sebastian for this detailed study! A great collaboration with our FMP colleague Han Sun, made possible by the DFG Forschergruppe Dynion

26.01.21 Andrew wrote apreview on the NMDA first latency paper from Amin and colleagues. This paper from the Wollmuth lab reports one of the most challenging measurements in electrophysiology, the first latency to opening of a single channel, and provides rich information about the control of gating by the linkers from the neurotransmitter binding domains to the channel pore. NMDA receptors singled out for delayed activation



Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)

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