In the Plested lab, we are interested in ion channel receptors and fast signalling in the nervous system. Receptors that are found at synapses between nerve cells have formed the backbone of our research for some years. The activation of these complex macromolecular machines is triggered by neurotransmitters in a fraction of a second. Our objective is to understand the relationship between the molecular structure of a given receptor (its shape) and its activity (what it does). More recently, we have become interested in the relation between receptor properties and synaptic signalling. 

We are members of the Humboldt University Institute for Biology, the NeuroCure Cluster of Excellence, and the Leibniz-Institut für Molekulare Pharmakologie (FMP). Our laboratories are located in the Marthe-Vogt-Haus (Haus 81) at the Campus Berlin Buch. If you would like to contact us, please write to the email address on the right.

Latest News

18.06.19 "A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength" is online at eLife, a collaboration with Benni König and Tobias Stauber. Yuchen Hao from our lab did the patch clamp fluorimetry to understand VRAC activation.

18.06.19 "Gating modules of the AMPA receptor pore domain revealed by unnatural amino acid mutagenesis" is online at PNAS. Congrats to Mette, Anahita, Vicky and Vale for all the hard work to complete this survey of the AMPA receptor pore domain. 

07.01.19 Niccolò has accepted an EMBO Long Term Fellowship. Congrats!

19.12.18 Andrew was very honoured to give the Gary Price Lecture at the annual meeting of the British Pharmacological Society. The lecture was entitled : "Glutamate Receptors : From structure to synapse". 

10.12.18 Our team from the Humboldt University was one of thirteen successful applicants in the DFG Innovative-Light-Microscopy competition. A modular, multichannel 2-photon microscope for optogenetics and imaging of neuronal activity will be built in the HU-Berlin Biophysics department. If you're interested to work with us on this project, get in touch!