Research

The group investigates in silico and experimental sequence-structure-function relationships of membrane proteins and interaction partners. Investigated systems include G-protein coupled receptors (GPCRs), transporters and tight junction proteins. In this context one strength is the development of bioinformatic tools that support the analysis of evolutionary and functionally relevant mutations. Furthermore, dedicated databases provide access to structure-function analysis of GPCRs (www.ssfa-gphr.de, www.ssfa-7tmr.de/p2y12) and include a toolkit to generate new GPCR models (www.ssfa-7tmr.de/ssfe).  The protein models guide experimental mutagenis of the respective protein. The main aims are:  i) rational discovery of molecular mechanisms and sites for protein-protein and protein-ligand interactions;  ii) pinpointing spatially interacting residues at the target protein by predicting functional sensitive residues that are subsequently evaluated experimentally, such as by site-directed mutagenesis or peptide mapping and iii) derive new molecules (small compounds or proteins) as counterparts for potential pharmacological intervention.

News

Patrick Marcinkowski and Inna Hoyer were successful in publishing the shared first authorship paper
Marcinkowski P* , Hoyer I *  et al., 2018

"A new highly thyrotropin receptor-selective antagonist with potential for the treatment of Graves’ orbitopathy"
in the high standing journal Thyroid.              15.12.2018 epub prior print