Publications
Publication Lists
Please feel free to download the following lists of FMP publications:
Publications 2014-2020, Section Molecular Physiology and Cell Biology (PDF)
Publications 2020
§, # equal contribution; * corresponding author(s); bold: FMP members
Alsalim, R., P. Lindemann, M. P. Lopez-Alberca, S. Miksche, W. Czechtizky, N. Halland*, M. Nazare*, A Palladium-Catalyzed Domino Reaction To Access 3-Amino-2H-indazoles from Hydrazines and 2-Halobenzonitriles. Org Lettonline ahead of print (2020). https://doi.org/10.1021/acs.orglett.0c02766
Barone, M., M. Müller, S. Chiha, J. Ren, D. Albat, A. Soicke, S. Dohmen, M. Klein, J. Bruns, M. van Dinther, R. Opitz, P. Lindemann, M. Beerbaum, K. Motzny, Y. Roske, P. Schmieder, R. Volkmer, M. Nazare, U. Heinemann, H. Oschkinat, P. Ten Dijke*, H. G. Schmalz*, R. Kühne*, Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells. Proc Natl Acad Sci USAonline ahead of print (2020). https://doi.org/10.1073/pnas.2007213117
Baumann, A. L., S. Schwagerus, K. Broi, K. Kemnitz-Hassanin, C. E. Stieger, N. Trieloff, P. Schmieder, C. P. R. Hackenberger*, Chemically Induced Vinylphosphonothiolate Electrophiles for Thiol-Thiol Bioconjugations. J Am Chem Soc142, 9544-9552 (2020). https://doi.org/10.1021/jacs.0c03426
Bertovic, I., R. Kurelic, I. Milosevic, M. Bender, M. Krauss, V. Haucke, A. Jurak Begonja*, Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes. J Thromb Haemost18, 1756-1772 (2020). https://doi.org/10.1111/jth.14764
Braun*, B. C., N. Halaski, J. Painer, E. Krause, K. Jewgenow, The antioxidative enzyme SOD2 is important for physiological persistence of corpora lutea in lynxes. Sci Rep10, 3681 (2020). https://doi.org/10.1038/s41598-020-60634-x
Brennecke, B., Q. Wang, Q. Zhang, H. Y. Hu*, M. Nazaré*, An Activatable Lanthanide Luminescent Probe for Time-Gated Detection of Nitroreductase in Live Bacteria. Angew Chem Int Ed59, 8512-8516 (2020). https://doi.org/10.1002/anie.202002391
Chilczuk, T., R. Monson, P. Schmieder, V. Christov, H. Enke, G. Salmond, T. H. J. Niedermeyer*, Ambigols from the Cyanobacterium Fischerella ambigua Increase Prodigiosin Production in Serratia spp. ACS Chem Biol15, 2929-2936 (2020). https://doi.org/10.1021/acschembio.0c00554
Chin, A. C., Z. Gao, A. M. Riley, D. Furkert, C. Wittwer, A. Dutta, T. Rojas, E. R. Semenza, R. A. Felder, J. L. Pluznick, H. J. Jessen, D. Fiedler, B. V. L. Potter, S. H. Snyder*, C. Fu*, The inositol pyrophosphate 5-InsP7 drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85alpha. Sci Adv6, eabb8542 (2020). https://doi.org/10.1126/sciadv.abb8542
Chow*, W. Y., B. P. Norman, N. B. Roberts, L. R. Ranganath, C. Teutloff, R. Bittl, M. J. Duer, J. A. Gallagher*, H. Oschkinat*, Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage. Angew Chem Int Ed59, 11937-11942 (2020). https://doi.org/10.1002/anie.202000618
Clochard, J., G. Jerz, P. Schmieder, H. Mitdank, M. Tröger, S. c. Sama, A. Weng, A new acetylated triterpene saponin from Agrostemma githago L. modulates gene delivery efficiently and shows a high cellular tolerance. Int J Pharmaceut589, 119822 (2020). https://doi.org/10.1016/j.ijpharm.2020.119822
D'Andrea, E. D., Y. Roske, G. A. P. de Oliveira, N. Cremer, A. Diehl, P. Schmieder, U. Heinemann, H. Oschkinat, J. R. Pires, Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi. J Struct Biol211, 107536 (2020). https://doi.org/10.1016/j.jsb.2020.107536
Dema, A., D. Faust, K. Lazarow, M. Wippich, M. Neuenschwander, K. Zühlke, A. Geelhaar, T. Pallien, E. Hallscheidt, J. Eichhorst, B. Wiesner, H. Cernecka, O. Popp, P. Mertins, G. Dittmar, J. P. von Kries, E. Klussmann, Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP. Cells9, E673 (2020). https://doi.org/10.3390/cells9030673
Desmarini, D., S. Lev, D. Furkert, B. Crossett, A. Saiardi, K. Kaufman-Francis, C. Li, T. C. Sorrell, L. Wilkinson-White, J. Matthews, D. Fiedler, J. T. Djordjevic*, IP7-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery. mBio11 (2020). https://doi.org/10.1128/mBio.01920-20
Dohmen, S., M. Reiher, D. Albat, S. Akyol, M. Barone, J. M. Neudorfl, R. Kühne, H. G. Schmalz*, Pd-Catalyzed Asymmetric N-Allylation of Amino Acid Esters with Exceptional Levels of Catalyst Control: Stereo-Divergent Synthesis of ProM-15 and Related Bicyclic Dipeptide Mimetics. Chemistry26, 3049-3053 (2020). https://doi.org/10.1002/chem.202000307
Ercu, M., L. Marko, C. Schächterle, D. Tsvetkov, Y. Cui, S. Maghsodi, T. U. P. Bartolomaeus, P. G. Maass, K. Zühlke, N. Gregersen, N. Hübner, R. Hodge, A. Mühl, B. Pohl, R. M. Illas, A. Geelhaar, S. Walter, H. Napieczynska, S. Schelenz, M. Taube, A. Heuser, Y. M. Anistan, F. Qadri, M. Todiras, R. Plehm, E. Popova, R. Langanki, J. Eichhorst, M. Lehmann, B. Wiesner, M. Russwurm, S. K. Forslund, I. Kamer, D. N. Müller, M. Gollasch, A. Aydin, S. Bähring, M. Bader, F. C. Luft, E. Klussmann, Phosphodiesterase 3A and Arterial Hypertension. Circulation142, 133-149 (2020). https://doi.org/10.1161/CIRCULATIONAHA.119.043061
Ernst, S., F. Ecker, M. S. Kaspers, P. Ochtrop, C. Hedberg, M. Groll, A. c. Itzen, Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination. Sci Adv6, eaaz8041 (2020). https://doi.org/10.1126/sciadv.aaz8041
Fang, Z., S. Chen, Y. Manchanda, P. Bitsi, P. Pickford, A. David, M. M. Shchepinova, I. Corrêa Jr, D. J. Hodson, J. Broichhagen, E. W. Tate, F. Reimann, V. Salem, G. A. Rutter, T. Tan, S. R. Bloom, A. Tomas, B. J. Jones, Ligand-specific factors influencing GLP-1R post-endocytic trafficking and degradation. Int J Mol Sci, accepted (2020).
Fang, Z., S. Chen, P. Pickford, J. Broichhagen, D. J. Hodson, I. R. Correa, Jr., S. Kumar, F. Görlitz, C. Dunsby, P. M. W. French, G. A. Rutter, T. Tan, S. R. Bloom, A. Tomas, B. Jones, The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists. ACS Pharmacol Transl Sci3, 345-360 (2020). https://doi.org/10.1021/acsptsci.0c00022
Finger, S., A. M. Kerth, M. Dathe, A. Blume, The impact of non-ideality of lipid mixing on peptide induced lipid clustering. Biochim Biophys Acta Biomembr1862, 183248 (2020). https://doi.org/10.1016/j.bbamem.2020.183248
Finkenwirth, F., M. Sippach, S. N. Pecina, M. Gade, J. Ruta, A. Ricke, E. Bondarenko, J. P. Klare, M. Zinke, S. Lange, A. Lange, H. J. Steinhoff, T. Eitinger, Dynamic interactions of CbiN and CbiM trigger activity of a cobalt energy-coupling-factor transporter. Biochim Biophys Acta Biomembr1862, 183114 (2020). https://doi.org/10.1016/j.bbamem.2019.183114
Friedrich, D., F. N. Brünig, A. J. Nieuwkoop, R. R. Netz, P. Hegemann, H. Oschkinat, Collective exchange processes reveal an active site proton cage in bacteriorhodopsin. Communications Biology3, 4 (2020). https://doi.org/10.1038/s42003-019-0733-7
Friedrich, D., J. Perodeau, A. J. Nieuwkoop*, H. Oschkinat*, MAS NMR detection of hydrogen bonds for protein secondary structure characterization. J Biomol NMR 74, 247-256 (2020). https://doi.org/10.1007/s10858-020-00307-z
Furkert, D., S. Hostachy, M. Nadler-Holly, D. Fiedler, Triplexed Affinity Reagents to Sample the Mammalian Inositol Pyrophosphate Interactome. Cell Chem Biol27, 1097-1108 (2020). https://doi.org/10.1016/j.chembiol.2020.07.017
Furkert, D., M. Nadler-Holly, D. Fiedler, Affinity-enrichment and identification of inositol poly- and pyrophosphate interactomes. STAR Methods in press, (2020).
Gallrein§, C., M. Iburg§, T. Michelberger, A. Kocak, D. Puchkov, F. Liu, S. M. Ayala Mariscal, T. Nayak, G. S. Kaminski Schierle, J. Kirstein, Novel Amyloid-beta pathology C. elegans model reveals distinct neurons as seeds of pathogenicity. Prog NeurobiolOnline ahead of print, 101907 (2020). https://doi.org/10.1016/j.pneurobio.2020.101907
Gericke, B., K. Römermann, A. f. Noack, S. Noack, J. Kronenberg, I. E. Blasig*, W. Löscher*, A face-to-face comparison of claudin-5 transduced human brain endothelial (hCMEC/D3) cells with porcine brain endothelial cells as blood-brain barrier models for drug transport studies. Fluids and barriers of the CNS17, 53 (2020). https://doi.org/10.1186/s12987-020-00212-5
Gerland*, L., D. Friedrich, L. Hopf, E. J. Donovan, A. Wallmann, N. Erdmann, A. Diehl, M. Bommer, K. Buzar, M. Ibrahim, P. Schmieder, H. Dobbek, A. Zouni, A. N. Bondar, H. Dau, H. Oschkinat*, pH-Dependent Protonation of Surface Carboxylate Groups in PsbO Enables Local Buffering and Triggers Structural Changes. ChemBioChem21, 1597-1604 (2020). https://doi.org/10.1002/cbic.201900739
Gonschior, H., V. Haucke, M. Lehmann, Super-Resolution Imaging of Tight and Adherens Junctions: Challenges and Open Questions. Int J Mol Sci21, 544 (2020). Review, https://doi.org/10.3390/ijms21030744
Gonzalez-Lozano, M. A., F. Koopmans, P. F. Sullivan, J. Protze, G. Krause, M. Verhage, K. W. Li*, F. Liu#*, A. B. Smit#*, Stitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions. Sci Adv6, eaax5783 (2020). https://doi.org/10.1126/sciadv.aax5783
Göppner, C., A. H. Soria, M. B. Hoegg-Beiler, T. J. Jentsch, Cellular basis of ClC-2 Cl- channel-related brain and testis pathologies. J Biol Chemin press (2020). https://doi.org/10.1074/jbc.RA120.016031
Gowrisankaran, S., S. Houy, J. G. P. del Castillo, V. Steubler, M. Gelker, J. Kroll, P. S. Pinheiro, D. Schwitters, N. Halbsgut, A. Pechstein, J. R. T. van Weering, T. Maritzen, V. Haucke, N. Raimundo, J. B. Sorensen, I. Milosevic, Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin. Nat Commun11, 1266 (2020). https://doi.org/10.1038/s41467-020-14993-8
Hackenberger, C. P. R., P. E. Dawson, Y. X. Chen, H. Hojo, Modern Peptide and Protein Chemistry: Reaching New Heights. J Org Chem85, 1328-1330 (2020). Editorial, https://doi.org/10.1021/acs.joc.0c00104
Haenig, C., N. Atias, A. K. Taylor, A. Mazza, M. H. Schaefer, J. Russ, S. P. Riechers, S. Jain, M. Coughlin, J. F. Fontaine, B. D. Freibaum, L. Brusendorf, M. Zenkner, P. Porras, M. Stroedicke, S. Schnoegl, K. Arnsburg, A. Boeddrich, L. Pigazzini, P. Heutink, J. P. Taylor, J. Kirstein, M. A. Andrade-Navarro, R. Sharan, E. E. Wanker, Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Cell Rep32, 108050 (2020). https://doi.org/10.1016/j.celrep.2020.108050
Hauser, A., S. Hwang, H. Sun*, C. P. R. Hackenberger*, Combining free energy calculations with tailored enzyme activity assays to elucidate substrate binding of a phospho-lysine phosphatase. Chem Sci (2020). https://doi.org/10.1039/D0SC03930F
Hauser, A., E. Poulou, F. Müller, P. Schmieder, C. P. R. Hackenberger, Synthesis and evaluation of non-hydrolyzable phospho-lysine peptide mimics. ChemistryOnline ahead of print, (2020). https://doi.org/10.1002/chem.202003947
Hecht-Höger, A. M., B. C. Braun, E. Krause, A. Meschede, R. Krahe, C. C. Voigt, A. D. Greenwood, G. A. Czirjak, Plasma proteomic profiles differ between European and North American myotid bats colonized by Pseudogymnoascus destructans. Mol Ecol 29, 1745-1755 (2020). https://doi.org/10.1111/mec.15437
Heidenreich, S., P. Weber, H. Stephanowitz, K. M. Petricek, T. Schütte, M. Oster, A. M. Salo, M. Knauer, I. Goehring, N. Yang, N. Witte, A. Schumann, M. Sommerfeld, M. Muenzner, J. Myllyharju, E. Krause, M. Schupp, The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation. J Biol Chem295, 17158-17168 (2020). https://doi.org/10.1074/jbc.RA120.014402
Hempel, C., J. Protze, E. Altun, B. Riebe , A. Piontek, A. Fromm , I. M. Lee, T. Saleh, D. Günzel, G. Krause, J. Piontek*, Assembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo-Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner. J Mol Biol432, 2405-2427 (2020). https://doi.org/10.1016/j.jmb.2020.02.034
Hoffmann, J., J. Ruta, C. Shi, K. Hendriks, V. Chevelkov, W. T. Franks, H. Oschkinat, K. Giller, S. Becker, A. Lange, Protein resonance assignment by BSH-CP based 3D solid-state NMR experiments: A practical guide. Magn Reson Chem58, 445-465 (2020). https://doi.org/10.1002/mrc.4945
Iburg, M., D. Puchkov, I. U. Rosas-Brugada, L. Bergemann, U. Rieprecht, J. Kirstein, The noncanonical small heat shock protein HSP-17 from Caenorhabditis elegans is a selective protein aggregase. J Biol Chem295, 3064-3079 (2020). https://doi.org/10.1074/jbc.RA119.011185
Jäpel, M., F. Gerth, T. Sakaba, J. Bacetic, L. J. Yao, S. J. Koo, T. Maritzen, C. Freund, V. Haucke, Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission. Cell Rep30, 409-420 (2020). https://doi.org/10.1016/j.celrep.2019.12.035
Jayapaul, J., L. Schröder, Probing Reversible Guest Binding with Hyperpolarized (129)Xe-NMR: Characteristics and Applications for Cucurbit[n]urils. Molecules25, 957 (2020). Review, https://doi.org/10.3390/molecules25040957
Jayapaul, J., L. Schröder, Molecular Sensing with Host Systems for Hyperpolarized (129)Xe. Molecules25, 4627 (2020). Review, https://doi.org/10.3390/molecules25204627
Kasper*, M. A., M. Gerlach, A. F. L. Schneider, C. Groneberg, P. Ochtrop, S. Boldt, D. Schumacher, J. Helma, H. Leonhardt, M. Christmann, C. P. R. Hackenberger*, N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates. ChemBioChem21, 113-119 (2020). https://doi.org/10.1002/cbic.201900587
Kircher, T., T. Pantsar, A. Oder, J. P. von Kries, M. Juchum, B. Pfaffenrot, P. Kloevekorn, W. Albrecht, R. Selig, S. Laufer, Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4. Eur J Med ChemOnline ahead of print, 112901 (2020). https://doi.org/10.1016/j.ejmech.2020.112901
Kobbersmed, J. R. L., A. T. Grasskamp, M. Jusyte, M. A. Böhme, S. Ditlevsen, J. B. Sorensen*, A. M. Walter*, Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca(2+) channel distances. Elife9, e51032 (2020). https://doi.org/10.7554/eLife.51032
Kohn, J. M., J. Riedel, J. Horsch, H. Stephanowitz, H. G. Börner, Mussel-Inspired Polymerization of Peptides: The Chemical Activation Route as Key to Broaden the Sequential Space of Artificial Mussel-Glue Proteins. Macromol Rapid Comm41, e1900431 (2020). https://doi.org/10.1002/marc.201900431
Krause*, G., K. M. Hinz, Molecular Mechanisms of Thyroid Hormone Transport by l-Type Amino Acid Transporter. Exp Clin Endocrinol Diab128, 379-382 (2020). Review, https://doi.org/10.1055/a-1032-8369
Kroll, J., O. D. Özcete, S. Jung, T. Maritzen, I. Milosevic, C. Wichmann, T. Moser, AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells. J Cell Sci133, jcs236737 (2020). https://doi.org/10.1242/jcs.236737
Kuijpers, M., G. Kochlamazashvili, A. Stumpf, D. Puchkov, A. Swaminathan, M. T. Lucht, E. Krause, T. Maritzen, D. Schmitz, V. Haucke, Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum. Neuron109, 1-15 (2020). https://doi.org/10.1016/j.neuron.2020.10.005
Kunth, M., L. Schröder*, Binding Site Exchange Kinetics Revealed Through Efficient Spin-Spin Dephasing of Hyperpolarized 129Xe. Chem Sciin print, (2020). https://doi.org/10.1039/d0sc04835f
Kutle, I., K. M. Szymanska-de Wijs, B. Bogdanow, B. Cuvalo, L. Steinbrück, S. Jonjic, K. Wagner, R. Niedenthal, M. Selbach, L. Wiebusch, M. Dezeljin, M. Messerle, Murine cytomegalovirus M25 proteins sequester the tumor suppressor protein p53 in nuclear accumulations. J VirolOnline ahead of print, (2020). https://doi.org/10.1128/JVI.00574-20
Laezer, I., S. E. Palma-Vera, F. Liu, M. Frank, N. Trakooljul, A. Vernunft, J. Schoen, S. Chen, Dynamic profile of EVs in porcine oviductal fluid during the periovulatory period. Reproduction159, 371-382 (2020). https://doi.org/10.1530/Rep-19-0219
Lämmle, C. A., A. Varady, T. G. Müller, C. Sturtzel, M. Riepl, B. Mathes, J. Eichhorst, A. Sporbert, M. Lehmann, H. G. Kräusslich, M. Distel, J. Broichhagen, Photocaged Hoechst Enables Subnuclear Visualization and Cell Selective Staining of DNA in vivo. ChemBioChem21, 1-10 (2020). https://doi.org/10.1002/cbic.202000465
Lauster§, D., S. Klenk§, K. Ludwig, S. Nojoumi, S. Behren, L. Adam, M. Stadtmüller, S. Saenger, S. Zimmler, K. Honzke, L. Yao, U. Hoffmann, M. Bardua, A. Hamann, M. Witzenrath, L. E. Sander, T. Wolff, A. C. Hocke, S. Hippenstiel, S. De Carlo, J. Neudecker, K. Osterrieder, N. Budisa, R. R. Netz, C. Böttcher, S. Liese*, A. Herrmann*, C. P. R. Hackenberger*, Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry. Nat Nanotechnol15, 373-379 (2020). https://doi.org/10.1038/s41565-020-0660-2
Leippe§, P., J. Broichhagen§, K. Cailliau, A. Mougel, M. Morel, C. Dissous, D. Trauner, J. Vicogne, Transformation of Receptor Tyrosine Kinases into Glutamate Receptors and Photoreceptors. Angew Chem Int Ed59, 6720-6723 (2020). Communications, https://doi.org/10.1002/anie.201915352
Li, M., R. Puschmann, A. Herdlitschka, D. Fiedler, H. Wennemers, Delivery ofmyo-Inositol Hexakisphosphate to the Cell Nucleus with a Proline-Based Cell-Penetrating Peptide. Angew Chem Int Ed59, 15586-15589 (2020). https://doi.org/10.1002/anie.202006770
Li, X. Y., C. F. Gu, S. Hostachy, S. Sahu, C. Wittwer, H. J. Jessen, D. Fiedler, H. C. Wang, S. B. Shears, Control of XPR1-dependent cellular phosphate efflux by InsP(8) is an exemplar for functionally-exclusive inositol pyrophosphate signaling. Proc. Natl. Acad. Sci. U.S.A. 117, 3568-3574 (2020). https://doi.org/10.1073/pnas.1908830117
Li§, X. L., L. P. Chi§, A. Navarro-Vazquez, S. Hwang, P. Schmieder, X. M. Li, X. Li, S. Q. Yang, X. X. Lei*, B. G. Wang*, H. Sun*, Stereochemical Elucidation of Natural Products from Residual Chemical Shift Anisotropies in a Liquid Crystalline Phase. J Am Chem Soc142, 2301-2309 (2020). https://doi.org/10.1021/jacs.9b10961
Liu, H., P. Chen, X. L. Li, H. Sun, X. X. Lei*, Practical aspects of oligopeptide AAKLVFF as an alignment medium for the measurements of residual dipolar coupling of organic molecules. Magn Reson Chem58, 404-410 (2020). https://doi.org/10.1002/mrc.4825
Liu, H., M. N. Paddock, H. Wang, C. J. Murphy, R. C. Geck, A. J. Navarro, G. M. Wulf, O. Elemento, V. Haucke, L. C. Cantley, A. Toker, The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer. Cancer Discovery10, 1226-1239 (2020). doi.org/10.1158/2159-8290
Lopez-Hernandez*, T., T. Maritzen*, V. Haucke*, Ramping up the autophagy-lysosome system to cope with osmotic stress. Autophagy16, 1921-1922 (2020). https://doi.org/10.1080/15548627.2020.1798065
Lopez-Hernandez*, T., D. Puchkov, E. Krause, T. Maritzen*, V. Haucke*, Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis. Nat Cell Biol22, 815-827 (2020). https://doi.org/10.1038/s41556-020-0535-7
Maaßen, A., J. M. Gebauer, E. T. Abraham, I. Grimm, J. M. Neudorfl, R. Kühne, I. Neundorf, U. Baumann, H. G. Schmalz, Triple-Helix-Stabilizing Effects in Collagen Model Peptides Containing PPII-Helix-Preorganized Diproline Modules. Angew Chem Int Ed59, 5747-5755 (2020). https://doi.org/10.1002/anie.201914101
Matthaeus, C., I. Lahmann, S. Kunz, W. Jonas, A. A. Melo, M. Lehmann, E. Larsson, R. Lundmark, M. Kern, M. Bluher, H. Olschowski, J. Kompa, B. Brügger, D. N. Müller, V. Haucke, A. Schürmann, C. Birchmeier, O. Daumke, EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake. Proc Natl Acad Sci USA117, 7471-7481 (2020). doi.org/10.1073/pnas.1918415117
Morrison, E., T. Wegner, A. E. Zucchetti, M. Alvaro-Benito, A. Zheng, S. Kliche, E. Krause, B. Brugger, C. Hivroz, C. Freund, Dynamic palmitoylation events following T-cell receptor signaling. Communications Biology 3, 368 (2020). https://doi.org/10.1038/s42003-020-1063-5
Mostinski, Y., G. Heynen, M. P. Lopez-Alberca, J. Paul, S. Miksche, S. Radetzki, D. Schaller, E. Shanina, C. Seyffarth, Y. Kolomeets, N. Ziebart, J. de Schryver, S. Oestreich, M. Neuenschwander, Y. Roske, U. Heinemann, C. Rademacher, A. Volkamer, J. P. von Kries, W. Birchmeier, M. Nazare, From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement. J Med Chem Online ahead of print, (2020). https://doi.org/10.1021/acs.jmedchem.0c01265
Nakamura, R., T. Numata, G. Kasuya*, T. Yokoyama, T. Nishizawa, T. Kusakizako, T. Kato, T. Hagino, N. Dohmae, M. Inoue, K. Watanabe, H. Ichijo, M. Kikkawa, M. Shirouzu, T. J. Jentsch, R. Ishitani, Y. Okada, O. Nureki, Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation. Commun Biol3, 240 (2020). https://doi.org/10.1038/s42003-020-0951-z
Nematian-Ardestani, E., F. Abd-Wahab, F. C. Chatelain, H. Sun, M. Schewe, T. Baukrowitz, S. J. Tucker, Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel. J Biol Chem295, 610-618 (2020). https://doi.org/10.1074/jbc.RA119.010612
Ochtrop, P., C. P. R. Hackenberger, Recent advances of thiol-selective bioconjugation reactions. Curr Opin Chem Biol58, 28-36 (2020). Review, https://doi.org/10.1016/j.cbpa.2020.04.017
Pavulraj, S., M. Kamel, H. Stephanowitz, F. Liu, J. Plendl, N. Osterrieder, W. Azab, Equine Herpesvirus Type 1 Modulates Cytokine and Chemokine Profiles of Mononuclear Cells for Efficient Dissemination to Target Organs. Viruses12, 999 (2020). https://doi.org/10.3390/v12090999
Pechstein§, A., N. Tomilin§, K. Fredrich§, O. Vorontsova, E. Sopova, E. Evergren, V. Haucke, L. Brodin, O. Shupliakov, Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation. Cell Rep30, 2594-2602 (2020). https://doi.org/10.1016/j.celrep.2020.01.092
Petzoldt, A. G., T. W. B. Götz, J. H. Driller, J. Lützkendorf, S. Reddy-Alla, T. Matkovic-Rachid, S. B. Liu, E. Knoche, S. Mertel, V. Ugorets, M. Lehmann, N. Ramesh, C. B. Beuschel, B. Kuropka, C. Freund, U. Stelzl, B. Loll, F. Liu, M. C. Wahl, S. J. Sigrist, RIM-binding protein couples synaptic vesicle recruitment to release sites. J Cell Biol219, e201902059 (2020). https://doi.org/10.1083/jcb.201902059
Pickford, P., M. Lucey, Z. J. Fang, S. Bitsi, J. B. de la Serna, J. Broichhagen, D. J. Hodson, J. Minnion, G. A. Rutter, S. R. Bloom, A. Tomas*, B. Jones, Signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide. Br J Pharmacol177, 3905-3923 (2020). https://doi.org/10.1111/bph.15134
Piontek, J., S. M. Krug, J. Protze, G. Krause, M. Fromm, Molecular architecture and assembly of the tight junction backbone. Bba-Biomembranes 1862, 183279 (2020). Review, https://doi.org/10.1016/j.bbamem.2020.183279
Piontek, A., M. Eichner, D. Zwanziger, L. S. Beier, J. Protze, W. Walther, S. Theurer, K. W. Schmid, D. Fuhrer-Sakel, J. Piontek*, G. Krause*, Targeting claudin-overexpressing thyroid and lung cancer by modified Clostridium perfringens enterotoxin. Mol Oncol14, 261-276 (2020). https://doi.org/10.1002/1878-0261.12615
Plested, A., V. Jayaraman, Biophysics of Membrane Protein Signaling. Biophys J118, E01-E01 (2020). Editorial, https://doi.org/10.1016/j.bpj.2020.02.001
Poc, P., V. A. Gutzeit, J. Ast, J. Lee, B. Jones, E. D'Este, B. Mathes, M. Lehmann, D. J. Hodson, J. Levitz, J. Broichhagen, Interrogating surfaceversusintracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates. Chem Sci11, 7871-7883 (2020). https://doi.org/10.1039/d0sc02794d
Polovitskaya§, M. M., C. Barbini§, D. Martinelli§, F. L. Harms, F. Sessions Cole, P. Calligari, G. Bocchinfuso, L. Stella, A. Ciolfi, M. Niceta, T. Rizza, M. Shinawi, K. Sisco, J. Johannsen, J. Denecke, R. Carrozzo, D. J. Wegner, K. Kutsche, M. Tartaglia*, T. J. Jentsch*, A recurrent gain-of-function mutation in CLCN6, encoding the ClC-6 Cl-/H+-exchanger, causes early-onset neurodegeneration. Am J Hum Genetin press (2020). https://doi.org/10.1016/j.ajhg.2020.11.004
Posor, Y., V. Haucke, A Golgi-associated lipid kinase controls peripheral nerve myelination. Proc Natl Acad Sci USA117, 30873-30875 (2020). Comment, https://doi.org/10.1073/pnas.2021130117
Preussner, M., Q. S. Gao, E. Morrison, O. Herdt, F. Finkernagel, M. Schümann, E. Krause, C. Freund, W. Chen, F. Heyd, Splicing-accessible coding 3 ' UTRs control protein stability and interaction networks. Genome Biol 21, 186 (2020). https://doi.org/10.1186/s13059-020-02102-3
Puschmann, R., R. K. Harmel, D. Fiedler, Methods Enzymol641, 35-52. Book Chapter, https://doi.org/10.1016/bs.mie.2020.04.035
Puyskens, A., A. Stinn, M. van der Vaart, A. Kreuchwig, J. Protze, G. Pei, M. Klemm, U. Guhlich-Bornhof, R. Hurwitz, G. Krishnamoorthy, M. Schaaf, G. Krause, A. H. Meijer, S. H. E. Kaufmann, P. Moura-Alves, Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes. Cell Host & Microbe27, 238-248 (2020). https://doi.org/10.1016/j.chom.2019.12.005
Qin, S. Y., Y. Jiang, H. Sun, H. Liu, A. Q. Zhang, X. X. Lei, Measurement of Residual Dipolar Couplings of Organic Molecules in Multiple Solvent Systems Using a Liquid-Crystalline-Based Medium. Angew Chem Int EdOnline ahead of print (2020). https://doi.org/10.1002/anie.202007243
Qiu, D., M. S. Wilson, V. B. Eisenbeis, R. K. Harmel, E. Riemer, T. M. Haas, C. Wittwer, N. Jork, S. B. Shears, G. Schaaf, B. Kammerer, D. Fiedler, A. Saiardi, H. J. Jessen, Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry. Nat Commun11, 6035 (2020).
Ried, M. K., R. Wild, J. Zhu, L. Broger, R. Harmel, L. A. Hothorn, D. Fiedler, S. Hiller, M. Hothorn, Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis. Nat Communin press (2020).
Rizalar, F. S., D. A. Roosen, V. Haucke, A Presynaptic Perspective on Transport and Assembly Mechanisms for Synapse Formation. NeuronOnline ahead of print (2020). Review, https://doi.org/10.1016/j.neuron.2020.09.038
Sahu, S., Z. Wang, X. Jiao, C. Gu, N. Jork, C. Wittwer, X. Li, S. Hostachy, D. Fiedler, H. Wang, H. J. Jessen, M. Kiledjian, S. B. Shears, InsP7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics. Proc Natl Acad Sci USA117 (2020).
Sandhof, C. A., S. O. Hoppe, S. Druffel-Augustin, C. Gallrein, J. Kirstein, C. Voisine, C. Nussbaum-Krammer, Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. Autophagy16, 878-899 (2020). https://doi.org/10.1080/15548627.2019.1643657
Sarott, R. C., M. V. Westphal, P. Pfaff, C. Korn, D. A. Sykes, T. Gazzi, B. Brennecke, K. Atz, M. Weise, Y. Mostinski, P. Hompluem, E. Koers, T. Miljus, N. J. Roth, H. Asmelash, M. C. Vong, J. Piovesan, W. Guba, A. C. Rufer, E. A. Kusznir, S. Huber, C. Raposo, E. A. Zirwes, A. Osterwald, A. Pavlovic, S. Moes, J. Beck, I. Benito-Cuesta, T. Grande, S. R. D. Esteban, A. Yeliseev, F. Drawnel, G. Widmer, D. Holzer, T. van der Wel, H. Mandhair, C. Y. Yuan, W. R. Drobyski, Y. Saroz, N. Grimsey, M. Honer, J. Fingerle, K. Gawrisch, J. Romero, C. J. Hillard, Z. V. Varga, M. van der Stelt, P. Pacher, J. Gertsch, P. J. McCormick, C. Ullmer, S. Oddi, M. Maccarrone, D. B. Veprintsev, M. Nazaré, U. Grether*, E. M. Carreira*, Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells. J Am Chem Soc142, 16953-16964 (2020). https://doi.org/10.1021/jacs.0c05587
Sawade, L., F. Grandi, M. Mignanelli, G. Patino-Lopez, K. Klinkert, F. Langa-Vives, R. Di Guardo, A. Echard, A. Bolino*, V. Haucke*, Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth. Nat Commun11, 2835 (2020). https://doi.org/10.1038/s41467-020-16696-6
Schneider, A. F. L., M. Kithil, M. C. Cardoso, M. Lehmann, C. P. R. Hackenberger, Cellular uptake of Large Biomolecules Enabled by Thiol-reactive Cell-penetrating Peptide Additives. Nat Chem in press (2020).
Schnirch, L., M. Nadler-Holly, S. W. Siao, C. K. Frese, R. Viner, F. Liu, Expanding the Depth and Sensitivity of Cross-Link Identification by Differential Ion Mobility Using High-Field Asymmetric Waveform Ion Mobility Spectrometry. Anal Chem92, 10495-10503 (2020). https://doi.org/10.1021/acs.analchem.0c01273
Schnurr, M., I. Volk, H. Nikolenko, L. Winkler, M. Dathe*, L. Schröder*, Functionalized Lipopeptide Micelles as Highly Efficient NMR Depolarization Seed Points for Targeted Cell Labelling in Xenon MRI. Adv Biosyst4, e1900251 (2020). https://doi.org/10.1002/adbi.201900251
Schuhmacher, M., A. T. Grasskamp, P. Barahtjan, N. Wagner, B. Lombardot, J. S. Schuhmacher, P. Sala, A. Lohmann, I. Henry, A. Shevchenko, U. Coskun, A. M. Walter*, A. Nadler*, Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities. Proc Natl Acad Sci USA117, 7729-7738 (2020). https://doi.org/10.1073/pnas.1912684117
Schwiebs, A., Y. Wang, A. M. Moore, X. D. Zhu, K. Pankow, W. E. Siems, T. Walther, The virtually mature B-type natriuretic peptide (BNP1-32) is a precursor for the more effective BNP1-30. Br J Pharmacol177, 1424-1433 (2020). https://doi.org/10.1111/bph.14890
Scott-Hewitt, N., F. Perrucci, R. Morini, M. Erreni, M. Mahoney, A. Witkowska, A. Carey, E. Faggiani, L. T. Schuetz, S. Mason, M. Tamborini, M. Bizzotto, L. Passoni, F. Filipello, R. Jahn, B. Stevens, M. Matteoli, Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia. EMBO J.39, e105380 (2020). https://doi.org/10.15252/embj.2020105380
Shytaj, I. L., B. Lucic, M. Forcato, C. Penzo, J. Billingsley, V. Laketa, S. Bosinger, M. Stanic, F. Gregoretti, L. Antonelli, G. Oliva, C. K. Frese, A. Trifunovic, B. Galy, C. Eibl, G. Silvestri, S. Bicciato, A. Savarino, M. Lusic, Alterations of redox and iron metabolism accompany the development of HIV latency. EMBO J39, e102209 (2020). https://doi.org/10.15252/embj.2019102209
Sreeramulu, S., C. Richter, T. Kuehn, K. Azzaoui, M. J. J. Blommers, R. Del Conte, M. Fragai, N. Trieloff, P. Schmieder, M. Nazaré, E. Specker, V. Ivanov, H. Oschkinat, L. Banci, H. Schwalbe, NMR quality control of fragment libraries for screening. J Biomol NMR, 10.1007/s10858-10020-00327-10859 (2020). https://doi.org/10.1007/s10858-020-00327-9
Stanifer, M. L., M. Mukenhirn, S. Muenchau, K. Pervolaraki, T. Kanaya, D. Albrecht, C. Odendall, T. Hielscher, V. Haucke, J. C. Kagan, S. Bartfeld, H. Ohno, S. Boulant, Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells. Nat Microbiol5, 181-191 (2020). https://doi.org/10.1038/s41564-019-0594-3
Tu, Z. X., E. G. Donskyi, H. S. Qiao, Z. L. Zhu, W. E. S. Unger, C. P. R. Hackenberger, W. Chen, M. Adeli, R. Haag, Graphene Oxide-Cyclic R10 Peptide Nuclear Translocation Nanoplatforms for the Surmounting of Multiple-Drug Resistance. Adv Funct Mater, 2000933 (2020). https://doi.org/10.1002/adfm.202000933
Visweshwaran*, S. P., A. Gautreau, Analysis of Random Migration of Cancer Cells in 3D. Bio-Protocol10, (2020). https://doi.org/10.21769/BioProtoc.3482
Waaler*, J., R. G. G. Leenders, S. T. Sowa, S. A. Brinch, M. Lycke, P. Nieczypor, S. Aertssen, S. Murthy, A. Galera-Prat, E. Damen, A. Wegert, M. Nazaré, L. Lehtio, S. Krauss, Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor. J Med Chem63, 6834-6846 (2020). https://doi.org/10.1021/acs.jmedchem.0c00208
Wang, C., R. Richter-Dennerlei, D. Pacheu-Grau, F. Liu, Y. Zhu, S. Dennerlein, P. Rehling, MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex. EMBO Rep21, e48833 (2020). https://doi.org/10.15252/embr.201948833
Wang, H. B., D. Loerke, C. Bruns, R. Müller, P. A. Koch, D. Puchkov, C. Schultz, V. Haucke, Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway. J Biol Chem295, 1091-1104 (2020). https://doi.org/10.1074/jbc.RA119.011774
Webel, H. E., T. B. Kimber, S. Radetzki, M. Neuenschwander, M. Nazaré, A. Volkamer, Revealing cytotoxic substructures in molecules using deep learning. J Comput Aid Mol Des34, 731-746 (2020). https://doi.org/10.1007/s10822-020-00310-4
Weinert, S., N. Gimber#, D. Deuschel#, T. Stuhlmann#, D. Puchkov#, Z. Farsi, C. F. Ludwig, G. Novarino, K. I. Lopez-Cayuqueo, R. Planells-Cases, T. J. Jentsch, Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration. EMBO J39, e103358 (2020). https://doi.org/10.15252/embj.2019103358
Wiglenda, T., N. Groenke, W. Hoffmann, C. Manz, L. Diez, A. Buntru, L. Brusendorf, N. Neuendorf, S. Schnoegl, C. Haenig, P. Schmieder, K. Pagel, E. E. Wanker, Sclerotiorin Stabilizes the Assembly of Nonfibrillar Abeta42 Oligomers with Low Toxicity, Seeding Activity, and Beta-sheet Content. J Mol Biol432, 2080-2098 (2020). https://doi.org/10.1016/j.jmb.2020.01.033
Winkler§, L., R. Blasig§, O. Breitkreuz-Korff, P. Berndt, S. Dithmer, H. C. Helms, D. Puchkov, K. Devraj, M. Kaya, Z. H. Qin, S. Liebner, H. Wolburg, A. V. Andjelkovic, A. Rex, I. E. Blasig, R. F. Haseloff, Tight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins. J Cerebr Blood F Met, 271678X20904687 (2020). https://doi.org/10.1177/0271678x20904687
Woitkuhn, J., A. Ender, C. B. Beuschel, M. Maglione, T. Matkovic-Rachid, S. Huang, M. Lehmann, J. R. P. Geiger, S. J. Sigrist, The Unc13A isoform is important for phasic release and olfactory memory formation at mushroom body synapses. J Neurogenet34, 106-114 (2020). https://doi.org/10.1080/01677063.2019.1710146
Xu, S. N., Q. Y. Zhang, X. W. Han, Y. L. Wang, X. Wang, M. Nazaré, J. D. Jiang, H. Y. Hu, Dual-Mode Detection of Bacterial 16S Ribosomal RNA in Tissues. ACS Sensors5, 1650-1656 (2020). https://doi.org/10.1021/acssensors.0c00252
Ye, M. Y., S. Li, X. J. Zhao, N. V. Tarakina, C. Teutloff, W. Y. Chow, R. Bittl, A. Thomas, Cobalt-Exchanged Poly(Heptazine Imides) as Transition Metal-N-x Electrocatalysts for the Oxygen Evolution Reaction. Adv Mater32, e1903942 (2020). https://doi.org/10.1002/adma.201903942
Yusenko, M. V., A. Trentmann, M. K. Andersson, L. A. Ghani, A. Jakobs, M. F. Arteaga Paz, J. H. Mikesch, J. P. von Kries, G. Stenman, K. H. Klempnauer, Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells. Cancer Letters479, 61-70 (2020). https://doi.org/10.1016/j.canlet.2020.01.039
Zajac, M., K. Chakraborty, S. Saha, V. Mahadevan, D. T. Infield, A. Accardi, Z. Z. Qiu, Y. Krishnan, What biologists want from their chloride reporters - a conversation between chemists and biologists. J Cell Sci133, jcs240390 (2020). Review, https://doi.org/10.1242/jcs.240390
Zhou§, C., X. Chen§, R. Planells-Cases§, J. C. Chu, L. Wang, L. M. Cao, Z. H. Li, K. I. Lopez-Cayuqueo, Y. D. Xie, S. W. Ye, X. Wang, F. Ullrich, S. X. Ma, Y. Y. Fang, X. M. Zhang, Z. K. Qian, X. Z. Liang, S. Q. Cai, Z. F. Jiang, D. M. Zhou, Q. B. Leng, T. S. Xiao, K. Lan, J. B. Yang, H. B. Li, C. Peng, Z. Z. Qiu*, T. J. Jentsch*, H. Xiao*, Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Immunity52, 767-781 (2020). https://doi.org/10.1016/j.immuni.2020.03.016
Zong, G., N. Jork, S. Hostachy, D. Fiedler, H. J. Jessen, S. B. Shears, H. Wang, New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1. FASEB J in press (2020).