Publications

Publications 2015

§, # equal contribution; * corresponding author(s); bold: FMP members

Agrawal, D., C. P. R. Hackenberger, in Chemistry of Organo-hybrids: Synthesis and Characterization of Functional Nano-Objects, B. Charleux, C. Coporet, E. Lacote, Eds. (Wiley, 2015). Book Chapter

Albert, G. I., C. Schell, K. M. Kirschner, S. Schäfer, R. Naumann, A. Müller, O. Kretz, B. Kuropka, M. Girbig, N. Hübner, E. Krause, H. Scholz*, T. B. Huber*, K. P. Knobeloch, C. Freund, The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function. J Mol Cell Biol7, 402-414 (2015). https://doi.org/10.1093/jmcb/mjv039

Alvaro-Benito, M., M. Wieczorek, J. Sticht, C. Kipar, C. Freund, HLA-DMA Polymorphisms Differentially Affect MHC Class II Peptide Loading. J Immunol194, 803-816 (2015). https://doi.org/10.4049/jimmunol.1401389

Balletta, A., D. Lorenz, A. Rummel, R. Gerhard, H. Bigalke, F. Wegner, Clostridium difficile toxin B inhibits the secretory response of human mast cell line-1 (HMC-1) cells stimulated with high free-Ca2+ and GTP gamma S. Toxicology328, 48-56 (2015). https://doi.org/10.1016/j.tox.2014.12.006

Bender§, F., M. Gorbati§, M. Carus-Cadavieco, N. Denisova, X. J. Gao, C. Holman, T. Korotkova*, A. Ponomarenko*, Theta oscillations regulate the speed of locomotion via a hippocampus to lateral septum pathway. Nat Commun6, 8521 (2015). https://doi.org/10.1038/ncomms9521

Bertran-Vicente, J., M. Schümann, P. Schmieder, E. Krause, C. P. R. Hackenberger, Direct access to site-specifically phosphorylated-lysine peptides from a solid-support. Org Biomol Chem13, 6839-6843 (2015). https://doi.org/10.1039/c5ob00734h

Bertran-Vicente*, J., M. Schümann, C. P. R. Hackenberger, E. Krause*, Gas-Phase Rearrangement in Lysine Phosphorylated Peptides During Electron-Transfer Dissociation Tandem Mass Spectrometry. Anal Chem87, 6990-6994 (2015). https://doi.org/10.1021/acs.analchem.5b01389

Broncel, M., R. A. Serwa, P. Ciepla, E. Krause, M. J. Dallman, A. I. Magee, E. W. Tate, Multifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development. Angew Chem Int Ed54, 5948-5951 (2015). https://doi.org/10.1002/anie.201500342

Broncel, M., R. A. Serwa, P. Ciepla, E. Krause, M. J. Dallman, A. I. Magee, E. W. Tate, Myristoylation profiling in human cells and zebrafish. Data Brief4, 379-383 (2015). https://doi.org/10.1016/j.dib.2015.06.010

Bruun, S., D. Stoeppler, A. Keidel, U. Kuhlmann, M. Luck, A. Diehl, M. A. Geiger, D. Woodmansee, D. Trauner, P. Hegemann, H. Oschkinat*, P. Hildebrandt*, K. Stehfest*, Light-Dark Adaptation of Channelrhodopsin Involves Photoconversion between the all-trans and 13-cis Retinal Isomers. Biochemistry-Us54, 5389-5400 (2015). https://doi.org/10.1021/acs.biochem.5b00597

Cai, Y. Y., E. N. Postnikova, J. G. Bernbaum, S. Q. Yu, S. Mazur, N. M. Deiuliis, S. R. Radoshitzky, M. G. Lackemeyer, A. McCluskey, P. J. Robinson, V. Haucke, V. Wahl-Jensen, A. L. Bailey, M. Lauck, T. C. Friedrich, D. H. O'Connor, T. L. Goldberg, P. B. Jahrling, J. H. Kuhna*, Simian Hemorrhagic Fever Virus Cell Entry Is Dependent on CD163 and Uses a Clathrin-Mediated Endocytosis-Like Pathway. J Virol89, 844-856 (2015). https://doi.org/10.1128/Jvi.02697-14

Chevelkov*, V., S. Q. Xiang, K. Giller, S. Becker, A. Lange, B. Reif, Perspectives for sensitivity enhancement in proton-detected solid-state NMR of highly deuterated proteins by preserving water magnetization. J Biomol NMR61, 151-160 (2015). https://doi.org/10.1007/s10858-015-9902-2

Cording, J., R. Günther, E. Vigolo, C. Tscheik, L. Winkler, I. Schlattner, D. Lorenz, R. F. Haseloff, K. M. Schmidt-Ott, H. Wolburg, I. E. Blasig, Redox Regulation of Cell Contacts by Tricellulin and Occludin: Redox-Sensitive Cysteine Sites in Tricellulin Regulate Both Tri- and Bicellular Junctions in Tissue Barriers as Shown in Hypoxia and Ischemia. Antioxid Redox Sign23, 1035-1049 (2015). Article doi.org/10.1089/ars.2014.6162

Dabrowski§, S., C. Staat§, D. Zwanziger, R. S. Sauer, C. Bellmann, R. Günther, E. Krause, R. F. Haseloff, H. Rittner, I. E. Blasig, Redox-Sensitive Structure and Function of the First Extracellular Loop of the Cell-Cell Contact Protein Claudin-1: Lessons from Molecular Structure to Animals. Antioxid Redox Sign22, 1-14 (2015). https://doi.org/10.1089/ars.2013.5706

Daniel, J. A., N. Chau, M. K. Abdel-Hamid, L. B. Hu, L. von Kleist, A. Whiting, S. Krishnan, P. Maamary, S. R. Joseph, F. Simpson, V. Haucke, A. McCluskey, P. J. Robinson, Phenothiazine-Derived Antipsychotic Drugs Inhibit Dynamin and Clathrin-Mediated Endocytosis. Traffic16, 635-654 (2015). https://doi.org/10.1111/tra.12272

Danielsson, J., X. Mu, L. Lang, H. B. Wang, A. Binolfi, F. X. Theillet, B. Bekei, D. T. Logan, P. Selenko, H. Wennerström, M. Oliveberg, Thermodynamics of protein destabilization in live cells. Proc Natl Acad Sci USA112, 12402-12407 (2015). https://doi.org/10.1073/pnas.1511308112

Diesenberg, K., M. Beerbaum, U. Fink, P. Schmieder, M. Krauss*, SEPT9 negatively regulates ubiquitin-dependent downregulation of EGFR. J Cell Sci128, 397-407 (2015). https://doi.org/10.1242/jcs.162206

Diezmann, F., L. von Kleist, V. Haucke, O. Seitz, Probing heterobivalent binding to the endocytic AP-2 adaptor complex by DNA-based spatial screening. Org Biomol Chem13, 8008-8015 (2015). https://doi.org/10.1039/c5ob00943j

Dufner, A., A. Kisser, S. Niendorf, A. Basters, S. Reissig, A. Schönle, A. Aichem, T. Kurz, A. Schlosser, D. Yablonski, M. Groettrup, T. Buch, A. Waisman, W. W. Schamel, M. Prinz, K. P. Knobeloch, The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells. Nat Immunol16, 950-960 (2015). https://doi.org/10.1038/ni.3230

Echard, A., V. Haucke, Lipids, GTPases, and their regulators in membrane dynamics: an intracellular menage a trois. Mol Biol Cell26, 1012-1013 (2015). Comment, https://doi.org/10.1091/mbc.E14-12-1593

Espinoza, S., V. Ghisi, M. Emanuele, D. Leo, I. Sukhanov, T. D. Sotnikova, E. Chieregatti, R. R. Gainetdinov, Postsynaptic D2 dopamine receptor supersensitivity in the striatum of mice lacking TAAR1. Neuropharmacology93, 308-313 (2015). https://doi.org/10.1016/j.neuropharm.2015.02.010

Fasshuber§, H. K., J. P. Demers§, V. Chevelkov, K. Giller, S. Becker, A. Lange, Specific C-13 labeling of leucine, valine and isoleucine methyl groups for unambiguous detection of long-range restraints in protein solid-state NMR studies. J Magn Reson252, 10-19 (2015). https://doi.org/10.1016/j.jmr.2014.12.013

Fasshuber, H. K., N. A. Lakomek*, B. Habenstein, A. Loquet, C. W. Shi, K. Giller, S. Wolff, S. Becker, A. Lange*, Structural heterogeneity in microcrystalline ubiquitin studied by solid-state NMR. Protein Sci24, 592-598 (2015). https://doi.org/10.1002/pro.2654

Feutlinske§, F., M. Browarski§, M. C. Ku, P. Trnka, S. Waiczies, T. Niendorf, W. B. Stallcup, R. Glass, E. Krause, T. Maritzen, Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility. Nat Commun6, 8535 (2015). https://doi.org/10.1038/ncomms9535

Fidzinski§, P., T. Korotkova§, M. Heidenreich§, N. Maier, S. Schuetze, O. Kobler, W. Zuschratter, D. Schmitz, A. Ponomarenko, T. J. Jentsch, KCNQ5 K+ channels control hippocampal synaptic inhibition and fast network oscillations. Nat Commun6, 6254 (2015). https://doi.org/10.1038/ncomms7254

Finger, S., A. Kerth, M. Dathe, A. Blume, The efficacy of trivalent cyclic hexapeptides to induce lipid clustering in PG/PE membranes correlates with their antimicrobial activity. Biochim Biophys Acta-Biomembr 1848, 2998-3006 (2015). https://doi.org/10.1016/j.bbamem.2015.09.012

Fischer, J., G. Kleinau, A. Müller, P. Kuehnen, D. Zwanziger, A. Kinne, M. Rehders, L. C. Moeller, D. Führer, A. Grüters, H. Krude, K. Brix, H. Biebermann, Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations. J Mol Endocrinol54, 39-50 (2015). https://doi.org/10.1530/Jme-14-0272

Fricke, P., V. Chevelkov, C. W. Shi, A. Lange, Strategies for solid-state NMR investigations of supramolecular assemblies with large subunit sizes. J Magn Reson253, 2-9 (2015). https://doi.org/10.1016/j.jmr.2014.10.018

Gattin, Z., R. Schneider, Y. Laukat, K. Giller, E. Maier, M. Zweckstetter, C. Griesinger, R. Benz, S. Becker, A. Lange, Solid-state NMR, electrophysiology and molecular dynamics characterization of human VDAC2. J Biomol NMR61, 311-320 (2015). https://doi.org/10.1007/s10858-014-9876-5

Gehne, N., R. F. Haseloff, I. E. Blasig, Identity crisis in the PMP-22/EMP/MP20/Claudin superfamily (Pfam00822). Tissue Barriers3,  (2015). Letter, https://doi.org/10.1080/21688370.2015.1089680

Gimber, N., G. Tadeus, T. Maritzen, J. Schmoranzer, V. Haucke, Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins. Nat Commun6, 8392 (2015). https://doi.org/10.1038/ncomms9392

Goody, R., V. Haucke, W. Just, FEBS Lett589, 1515 (2015). Editorial, https://doi.org/10.1016/j.febslet.2015.05.011

Grosskopf, S., C. Eckert, C. Arkona, S. Radetzki, K. Böhm, U. Heinemann, G. Wolber, J. P. von Kries, W. Birchmeier, J. Rademann, Selective Inhibitors of the Protein Tyrosine Phosphatase SHP2 Block Cellular Motility and Growth of Cancer Cells in vitro and in vivo. ChemMedChem10, 815-826 (2015). https://doi.org/10.1002/cmdc.201500015

Grzesik, P., A. Kreuchwig, C. Rutz, J. Furkert, B. Wiesner, R. Schülein, G. Kleinau, J. Gromoll, G. Krause, Differences in signal activation by LH and hcg are mediated by the LH/CG receptor's extracellular hinge region. Front Endocrinol6,  (2015). https://doi.org/10.3389/fendo.2015.00140

Günther, R., E. Krause, M. Schümann, I. E. Blasig, R. F. Haseloff, Depletion of highly abundant proteins from human cerebrospinal fluid: a cautionary note. Mol Neurodegener10,  (2015). Editorial, https://doi.org/10.1186/s13024-015-0050-7

Habenstein, B., A. Loquet, S. H. Hwang, K. Giller, S. K. Vasa, S. Becker, M. Habeck*, A. Lange*, Hybrid Structure of the Type 1 Pilus of Uropathogenic Escherichia coli. Angew Chem Int Ed54, 11691-11695 (2015). https://doi.org/10.1002/anie.201505065

Hackenberger, C. P. R., P. R. Chen, Editorial overview: Synthetic biomolecules: Synthetic protein modifications - a giant leap towards understanding and generating biological functions. Curr Opin Chem Biol28, VII-IX (2015). Editorial, https://doi.org/10.1016/j.cbpa.2015.09.005

Halland*, N., F. Schmidt, T. Weiss, J. Saas, Z. Y. Li, J. Czech, M. Dreyer, A. Hofmeister, K. Mertsch, U. Dietz, C. Strubing, M. Nazaré, Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]sulfonamides as Highly Active and Selective SGK1 Inhibitors. ACS Med Chem Lett6, 73-78 (2015). https://doi.org/10.1021/ml5003376

Haseloff, R. F., S. Dithmer, L. Winkler, H. Wolburg, I. E. Blasig, Transmembrane proteins of the tight junctions at the blood-brain barrier: Structural and functional aspects. Semin Cell Dev Biol38, 16-25 (2015). Review, https://doi.org/10.1016/j.semcdb.2014.11.004

Haucke, V., Hopping Pits Catch Fusing Granules. Dev Cell35, 10-11 (2015). Editorial, https://doi.org/10.1016/j.devcel.2015.09.026

Haucke, V., On the endocytosis rollercoaster. Nature517, 446-447 (2015). Editorial, https://doi.org/10.1038/nature14081

Haucke, V., B. S. Glick, Gottfried Schatz (1936-2015)-mitochondrial pioneer and ambassador for science Obituary. EMBO J34, 2725-2726 (2015). Biographical Item, https://doi.org/10.15252/embj.201593299

Hecht, A. M., B. C. Braun, E. Krause, C. C. Voigt, A. D. Greenwood, G. A. Czirjak, Plasma proteomic analysis of active and torpid greater mouseeared bats (Myotis myotis). Sci Rep5, 16604 (2015). https://doi.org/10.1038/srep16604

Henning, L. M., S. Bhatia, M. Bertazzon, M. Marczynke, O. Seitz, R. Volkmer, R. Haag, C. Freund, Exploring monovalent and multivalent peptides for the inhibition of FBP21-tWW. Beilstein J Org Chem11, 701-706 (2015). https://doi.org/10.3762/bjoc.11.80

Herrada, I., C. Samson, C. Velours, L. Renault, C. Ostlund, P. Chervy, D. Puchkov, H. J. Worman, B. Buendia, S. Zinn-Justin, Muscular Dystrophy Mutations Impair the Nuclear Envelope Emerin Self-assembly Properties. ACS Chem Biol10, 2733-2742 (2015). https://doi.org/10.1021/acschembio.5b00648

Hinz, K. M., K. Meyer, A. Kinne, R. Schülein, J. Köhrle, G. Krause, Structural Insights Into Thyroid Hormone Transport Mechanisms of the L-Type Amino Acid Transporter 2. Mol Endocrinol29, 933-942 (2015). https://doi.org/10.1210/me.2015-1044

Hu, H. Y., N. H. Lim, D. Ding-Pfennigdorff, J. Saas, K. U. Wendt, O. Ritzeler, H. Nagase, O. Plettenburg, C. Schultz*, M. Nazaré*, DOTAM Derivatives as Active Cartilage-Targeting Drug Carriers for the Treatment of Osteoarthritis. Bioconjugate Chem26, 383-388 (2015). https://doi.org/10.1021/bc500557s

Hu, H. Y., N. H. Lim, H. P. Juretschke, D. Ding-Pfennigdorff, P. Florian, M. Kohlmann, A. Kandira, J. P. von Kries, J. Saas, K. A. Rudolphi, K. U. Wendt, H. Nagase, O. Plettenburg, M. Nazaré*, C. Schultz*, In vivo visualization of osteoarthritic hypertrophic lesions. Chem Sci6, 6256-6261 (2015). https://doi.org/10.1039/c5sc01301a

Huber, R. G., C. Eibl, J. E. Fuchs, Intrinsic flexibility of NLRP pyrin domains is a key factor in their conformational dynamics, fold stability, and dimerization. Protein Sci24, 174-181 (2015). https://doi.org/10.1002/pro.2601

Jentsch, T. J., Discovery of CLC transport proteins: cloning, structure, function and pathophysiology. J Physiol-London593, 4091-4109 (2015). Review, https://doi.org/10.1113/Jp270043

Jentsch*, T. J., M. B. Hoegg-Beiler, J. Vogt, Departure gate of acidic Ca2+ confirmed. EMBO J34, 1737-1739 (2015). Editorial, https://doi.org/10.15252/embj.201591884

Jung§, S. Y., T. Maritzen§, C. Wichmann§, Z. Z. Jing, A. Neef*, N. H. Revelo, H. Al-Moyed, S. Meese, S. M. Wojcik, I. Panou, H. Bulut, P. Schu, R. Ficner, E. Reisinger, S. O. Rizzoli, J. Neef, N. Strenzke, V. Haucke*, T. Moser*, Disruption of adaptor protein 2 mu (AP-2 mu) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing. EMBO J34, 2686-2702 (2015). https://doi.org/10.15252/embj.201591885

Kaempf, N., G. Kochlamazashvili, D. Puchkov, T. Maritzen, S. M. Bajjalieh, N. L. Kononenko*, V. Haucke*, Overlapping functions of stonin 2 and SV2 in sorting of the calcium sensor synaptotagmin 1 to synaptic vesicles. Proc Natl Acad Sci USA112, 7297-7302 (2015). https://doi.org/10.1073/pnas.1501627112

Kinne*, A., M. Wittner, E. K. Wirth, K. M. Hinz, R. Schülein, J. Köhrle, G. Krause*, Involvement of the L-Type Amino Acid Transporter Lat2 in the Transport of 3,3 ' -Diiodothyronine across the Plasma Membrane. Eur Thyroid J4, 42-50 (2015). https://doi.org/10.1159/000381542

Kirstein*§, J., D. Morito§, T. Kakihana§, M. Sugihara, A. Minnen, M. S. Hipp, C. Nussbaum-Krammer, P. Kasturi, F. U. Hartl*, K. Nagata*, R. I. Morimoto*, Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments. EMBO J34, 2334-2349 (2015). https://doi.org/10.15252/embj.201591711

Klein, W., C. Westendorf, A. Schmidt, M. Conill-Cortes, C. Rutz, M. Blohs, M. Beyermann, J. Protze, G. Krause, E. Krause, R. Schülein, Defining a Conformational Consensus Motif in Cotransin-Sensitive Signal Sequences: A Proteomic and Site-Directed Mutagenesis Study. PLoS One10, e0120886 (2015). https://doi.org/10.1371/journal.pone.0120886

Klingberg, R., J. O. Jost, M. Schümann, K. A. Gelato, W. Fischle, E. Krause, D. Schwarzer, Analysis of Phosphorylation-Dependent Protein Protein Interactions of Histone H3. ACS Chem Biol10, 138-145 (2015). https://doi.org/10.1021/cb500563n

Kononenko, N. L., V. Haucke, Molecular Mechanisms of Presynaptic Membrane Retrieval and Synaptic Vesicle Reformation. Neuron85, 484-496 (2015). Review, https://doi.org/10.1016/j.neuron.2014.12.016

Koo§, S. J., G. Kochlamazashvili§, B. Rost, D. Puchkov, N. Gimber, M. Lehmann, G. Tadeus, J. Schmoranzer, C. Rosenmund, V. Haucke*, T. Maritzen*, Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission. Neuron88, 330-344 (2015). https://doi.org/10.1016/j.neuron.2015.08.034

Koschek, K., V. Durmaz, O. Krylova, M. Wieczorek, S. Gupta, M. Richter, A. Bujotzek, C. Fischer, R. Haag, C. Freund, M. Weber, J. Rademann, Peptide-polymer ligands for a tandem WW-domain, an adaptive multivalent protein-protein interaction: lessons on the thermodynamic fitness of flexible ligands. Beilstein J Org Chem11, 837-847 (2015). https://doi.org/10.3762/bjoc.11.93

Krause*, G., J. Protze, J. Piontek, Assembly and function of claudins: Structure-function relationships based on homology models and crystal structures. Semin Cell Dev Biol42, 3-12 (2015). Review, https://doi.org/10.1016/j.semcdb.2015.04.010

Krauss*, M., V. Haucke*, A grab to move on: ER-endosome contacts in membrane protrusion formation and neurite outgrowth. EMBO J34, 1442-1444 (2015). Editorial, https://doi.org/10.15252/embj.201591553

Kuhlmann, M., O. Reimann, C. P. R. Hackenberger, J. Groll, Cysteine-Functional Polymers via Thiol-ene Conjugation. Macromol Rapid Comm36, 472-476 (2015). https://doi.org/10.1002/marc.201400703

Kunth, M., C. Witte, A. Hennig, L. Schröder, Identification, classification, and signal amplification capabilities of high-turnover gas binding hosts in ultra-sensitive NMR. Chem Sci6, 6069-6075 (2015). https://doi.org/10.1039/c5sc01400j

Kunth, M., C. Witte, L. Schröder, Continuous-wave saturation considerations for efficient xenon depolarization. NMR Biomed28, 601-606 (2015). https://doi.org/10.1002/nbm.3307

Kuropka, B., N. Royla, C. Freund, E. Krause*, Sortase A mediated site-specific immobilization for identification of protein interactions in affinity purification-mass spectrometry experiments. Proteomics15, 1230-1234 (2015). https://doi.org/10.1002/pmic.201400395

Kuropka§, B., A. Witte§, J. Sticht, N. Waldt, P. Majkut, C. P. R. Hackenberger, B. Schraven, E. Krause*, S. Kliche*, C. Freund*, Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration. Mol Cell Proteomics14, 2961-2972 (2015). https://doi.org/10.1074/mcp.M115.048249

Lampe, A., G. Tadeus, J. Schmoranzer, Spectral demixing avoids registration errors and reduces noise in multicolor localization-based super-resolution microscopy. Methods Appl Fluores3,  (2015). https://doi.org/10.1088/2050-6120/3/3/034006

Lan, L. X., J. D. Holland, J. J. Qi, S. Grosskopf, J. Rademann, R. Vogel, B. Gyorffy, A. Wulf-Goldenberg, W. Birchmeier, Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice. EMBO J34, 1493-1508 (2015). https://doi.org/10.15252/embj.201489004

Lehmann§*, M., B. Gottschalk§, D. Puchkov, P. Schmieder, S. Schwagerus, C. P. R. Hackenberger, V. Haucke, J. Schmoranzer*, Multicolor Caged dSTORM Resolves the Ultrastructure of Synaptic Vesicles in the Brain. Angew Chem Int Ed54, 13230-13235 (2015). https://doi.org/10.1002/anie.201505138

Mainz, A., J. Peschek, M. Stavropoulou, K. C. Back, B. Bardiaux, S. Asami, E. Prade, C. Peters, S. Weinkauf, J. Buchner, B. Reif, The chaperone alpha B-crystallin uses different interfaces to capture an amorphous and an amyloid client. Nat Struct Mol Biol22, 898-905 (2015). https://doi.org/10.1038/nsmb.3108

Man, K. N. M., C. Imig, A. M. Walter, P. S. Pinheiro, D. R. Stevens, J. Rettig, J. B. Sörensen, B. H. Cooper, N. Brose, S. M. Wojcik, Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis. Elife4, e10635 (2015). https://doi.org/10.7554/eLife.10635

Marino, J., N. Bordag, S. Keller, O. Zerbe, Mistic's membrane association and its assistance in overexpression of a human GPCR are independent processes. Protein Sci24, 38-48 (2015). https://doi.org/10.1002/pro.2582

Maritzen*, T., H. Schachtner, D. F. Legler*, On the move: endocytic trafficking in cell migration. Cell Mol Life Sci72, 2119-2134 (2015). Review, https://doi.org/10.1007/s00018-015-1855-9

Mentink-Vigier, F., U. Akbey, H. Oschkinat, S. Vega, A. Feintuch, Theoretical aspects of Magic Angle Spinning - Dynamic Nuclear Polarization. J Magn Reson258, 102-120 (2015). https://doi.org/10.1016/j.jmr.2015.07.001

Milatz, S., J. Piontek, J. D. Schulzke, I. E. Blasig, M. Fromm, D. Günzel, Probing the cis-arrangement of prototype tight junction proteins claudin-1 and claudin-3. Biochem J468, 449-458 (2015). https://doi.org/10.1042/Bj20150148

Miotto, M. C., A. A. Valiente-Gabioud, G. Rossetti, M. Zweckstetter, P. Carloni, P. Selenko, C. Griesinger, A. Binolfi*, C. O. Fernandez*, Copper Binding to the N-Terminally Acetylated, Naturally Occurring Form of Alpha-Synuclein Induces Local Helical Folding. J Am Chem Soc137, 6444-6447 (2015). https://doi.org/10.1021/jacs.5b01911

Morrison, E., B. Kuropka, S. Kliche, B. Brügger, E. Krause*, C. Freund*, Quantitative analysis of the human T cell palmitome. Sci Rep5, 11598 (2015). https://doi.org/10.1038/srep11598

Muench, F., J. Retel, S. Jeuthe, D. O. h-Ici, B. van Rossum, K. Wassilew, P. Schmerler, T. Kuehne, F. Berger, H. Oschkinat, D. R. Messroghli, Alterations in creatine metabolism observed in experimental autoimmune myocarditis using ex vivo proton magic angle spinning MRS. NMR Biomed28, 1625-1633 (2015). https://doi.org/10.1002/nbm.3415

Muhammad, K., S. Reddy-Alla, J. H. Driller, D. Schreiner, U. Rey, M. A. Böhme, C. Hollmann, N. Ramesh, H. Depner, J. Lützkendorf, T. Matkovic, T. Götz, D. D. Bergeron, J. Schmoranzer, F. Goettfert, M. Holt, M. C. Wahl, S. W. Hell, P. Scheiffele, A. M. Walter, B. Loll, S. J. Sigrist, Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function. Nat Commun6, 8362 (2015). https://doi.org/10.1038/ncomms9362

Mühlberg§, M., M. G. Hoesl§, C. Kuehne, J. Dernedde, N. Budisa*, C. P. R. Hackenberger*, Orthogonal dual-modification of proteins for the engineering of multivalent protein scaffolds. Beilstein J Org Chem11, 784-791 (2015). https://doi.org/10.3762/bjoc.11.88

Nieuwkoop, A. J., W. T. Franks, K. Rehbein, A. Diehl, U. Akbey, F. Engelke, L. Emsley, G. Pintacuda, H. Oschkinat, Sensitivity and resolution of proton detected spectra of a deuterated protein at 40 and 60 kHz magic-angle-spinning. J Biomol NMR61, 161-171 (2015). https://doi.org/10.1007/s10858-015-9904-0

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Nischan, N., H. D. Herce, F. Natale, N. Bohlke, N. Budisa, M. C. Cardoso, C. P. R. Hackenberger, Covalent Attachment of Cyclic TAT Peptides to GFP Results in Protein Delivery into Live Cells with Immediate Bioavailability. Angew Chem Int Ed54, 1950-1953 (2015). https://doi.org/10.1002/anie.201410006

Opitz§, R., M. Müller§, C. Reuter§, M. Barone§, A. Soicke, Y. Roske, K. Piotukh, P. Huy, M. Beerbaum, B. Wiesner, M. Beyermann, P. Schmieder, C. Freund, R. Volkmer, H. Oschkinat, H. G. Schmalz*, R. Kühne*, A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions. Proc Natl Acad Sci USA112, 5011-5016 (2015). https://doi.org/10.1073/pnas.1422054112

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Planells-Cases, R., D. Lutter, C. Guyader, N. M. Gerhards, F. Ullrich, D. A. Elger, A. Kucukosmanoglu, G. T. Xu, F. K. Voss, S. M. Reincke, T. Stauber, V. A. Blomen, D. J. Vis, L. F. Wessels, T. R. Brummelkamp, P. Borst, S. Rottenberg*, T. J. Jentsch*, Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs. EMBO J34, 2993-3008 (2015). https://doi.org/10.15252/embj.201592409

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Protze, J., M. Eichner, A. Piontek, S. Dinter, J. Rossa, K. G. Z. Blecharz, P. Vajkoczy, J. Piontek, G. Krause*, Directed structural modification of Clostridium perfringens enterotoxin to enhance binding to claudin-5. Cell Mol Life Sci72, 1417-1432 (2015). https://doi.org/10.1007/s00018-014-1761-6

Reimann, O., M. Glanz, C. P. R. Hackenberger, Native chemical ligation between asparagine and valine: Application and limitations for the synthesis of tri-phosphorylated C-terminal tau. Bioorgan Med Chem23, 2890-2894 (2015). https://doi.org/10.1016/j.bmc.2015.03.028

Reimann, O., C. Smet-Nocca, C. P. R. Hackenberger, Traceless Purification and Desulfurization of Tau Protein Ligation Products. Angew Chem Int Ed54, 306-310 (2015). https://doi.org/10.1002/anie.201408674

Reubold, T. F., K. Faelber, N. Plattner, Y. Posor, K. Ketel, U. Curth, J. Schlegel, R. Anand, D. J. Manstein, F. Noe, V. Haucke, O. Daumke, S. Eschenburg, Crystal structure of the dynamin tetramer. Nature525, 404-408 (2015). https://doi.org/10.1038/nature14880

Reuter, C., R. Opitz, A. Soicke, S. Dohmen, M. Barone, S. Chiha, M. T. Klein, J. M. Neudorfl, R. Kühne*, H. G. Schmalz*, Design and Stereoselective Synthesis of ProM-2: A Spirocyclic Diproline Mimetic with Polyproline Type II (PPII) Helix Conformation. Chem Eur J21, 8464-8470 (2015). https://doi.org/10.1002/chem.201406493

Rosenlöcher, J., V. Böhrsch, M. Sacharjat, V. Blanchard, C. Giese, V. Sandig, C. P. R. Hackenberger, S. Hinderlich, Applying Acylated Fucose Analogues to Metabolic Glycoengineering. Bioengineering2, 213-234 (2015). https://doi.org/10.3390/bioengineering2040213

Rost, B. R., F. Schneider, M. K. Grauel, C. Wozny, C. G. Bentz, A. Blessing, T. Rosenmund, T. J. Jentsch, D. Schmitz, P. Hegemann, C. Rosenmund, Optogenetic acidification of synaptic vesicles and lysosomes. Nat Neurosci18, 1845-1852 (2015). https://doi.org/10.1038/nn.4161

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Rutz, C., W. Klein, R. Schülein, N-Terminal Signal Peptides of G Protein-Coupled Receptors: Significance for Receptor Biosynthesis, Trafficking, and Signal Transduction. Prog Mol Biol Transl Sci132, 267-287 (2015). Review, https://doi.org/10.1016/bs.pmbts.2015.03.003

Schachtner§, H., M. Weimershaus§, V. Stache, N. Plewa, D. F. Legler, U. E. Höpken, T. Maritzen*, Loss of Gadkin Affects Dendritic Cell Migration In Vitro. PLoS One10, e0143883 (2015). https://doi.org/10.1371/journal.pone.0143883

Scheinpflug, K., O. Krylova, H. Nikolenko, C. Thurm, M. Dathe, Evidence for a Novel Mechanism of Antimicrobial Action of a Cyclic R-,W-Rich Hexapeptide. PLoS One10, e125056 (2015). https://doi.org/10.1371/journal.pone.0125056

Schmitz, M., M. Kuhlmann, O. Reimann, C. P. R. Hackenberger, J. Groll, Side-Chain Cysteine-Functionalized Poly(2-oxazoline)s for Multiple Peptide Conjugation by Native Chemical Ligation. Biomacromolecules16, 1088-1094 (2015). https://doi.org/10.1021/bm501697t

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Schnurr§, M., J. Sloniec-Myszk§, J. Döpfert, L. Schröder*, A. Hennig*§, Supramolecular Assays for Mapping Enzyme Activity by Displacement-Triggered Change in Hyperpolarized Xe-129 Magnetization Transfer NMR Spectroscopy. Angew Chem Int Ed54, 13444-13447 (2015). https://doi.org/10.1002/anie.201507002

Schnurr, M., K. Sydow, H. M. Rose, M. Dathe, L. Schröder, Brain Endothelial Cell Targeting Via a Peptide-Functionalized Liposomal Carrier for Xenon Hyper-CEST MRI. Adv Healthc Mater4, 40-45 (2015). https://doi.org/10.1002/adhm.201400224

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Schubeis, T., P. Yuan, M. Ahmed, M. Nagaraj, B. J. van Rossum, C. Ritter, Untangling a Repetitive Amyloid Sequence: Correlating Biofilm-Derived and Segmentally Labeled Curli Fimbriae by Solid-State NMR Spectroscopy. Angew Chem Int Ed54, 14669-14672 (2015). https://doi.org/10.1002/anie.201506772

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Schumacher§, D., J. Helma§, F. A. Mann, G. Pichler, F. Natale, E. Krause, M. C. Cardoso, C. P. R. Hackenberger*, H. Leonhardt*, Versatile and Efficient Site-Specific Protein Functionalization by Tubulin Tyrosine Ligase. Angew Chem Int Ed54, 13787-13791 (2015). https://doi.org/10.1002/anie.201505456

Seifert, W., J. Kühnisch, T. Maritzen, S. Lommatzsch, H. C. Hennies, S. Bachmann, D. Horn, V. Haucke, Cohen Syndrome-associated Protein COH1 Physically and Functionally Interacts with the Small GTPase RAB6 at the Golgi Complex and Directs Neurite Outgrowth. J Biol Chem290, 3349-3358 (2015). https://doi.org/10.1074/jbc.M114.608174

Serwa, R. A., F. Abaitua, E. Krause, E. W. Tate, P. O'Hare, Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics. Chem Biol22, 1008-1017 (2015). https://doi.org/10.1016/j.chembiol.2015.06.024

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Shymanets, A., Prajwal, O. Vadas, C. Czupalla, J. LoPiccolo, M. Brenowitz, A. Ghigo, E. Hirsch, E. Krause, R. Wetzker, R. L. Williams, C. Harteneck, B. Nürnberg, Different inhibition of G beta gamma-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a G beta gamma-dependent regulator of PI3K gamma enzymatic activity. Biochem J469, 59-69 (2015). https://doi.org/10.1042/Bj20150099

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Tadeus, G., A. Lampe, J. Schmoranzer, SDmixer-a versatile software tool for spectral demixing of multicolor single molecule localization data. Methods Appl Fluores3, 037001 (2015). https://doi.org/10.1088/2050-6120/3/3/037001

Thongwichian, R., J. Kosten, U. Benary, H. M. Rose, M. Stuiver, F. X. Theillet, A. Dose, B. Koch, H. Yokoyama, D. Schwarzer, J. Wolf, P. Selenko*, A Multiplexed NMR-Reporter Approach to Measure Cellular Kinase and Phosphatase Activities in Real-Time. J Am Chem Soc137, 6468-6471 (2015). https://doi.org/10.1021/jacs.5b02987

Vallee, M. R. J., P. Majkut, D. Krause, M. Gerrits, C. P. R. Hackenberger, Chemoselective Bioconjugation of Triazole Phosphonites in Aqueous Media. Chem Eur J21, 970-974 (2015). https://doi.org/10.1002/chem.201404690

Varga, R. E., M. Khundadze, M. Damme, S. Nietzsche, B. Hoffmann, T. Stauber, N. Koch, J. C. Hennings, P. Franzka, A. K. Huebner, M. M. Kessels, C. Biskup, T. J. Jentsch, B. Qualmann, T. Braulke, I. Kurth, C. Beetz, C. A. Hübner, In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11. PLoS Genet11, e1005454 (2015). https://doi.org/10.1371/journal.pgen.1005454

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Verkman, A. S., A. Edelman, M. Amaral, M. A. Mall, J. M. Beekman, T. Meiners, L. J. V. Galietta, C. E. Bear, Finding new drugs to enhance anion secretion in cystic fibrosis: Toward suitable systems for better drug screening. Report on the pre-conference meeting to the 12th ECFS Basic Science Conference, Albufeira, 25-28 March 2015. J Cyst Fibros14, 700-705 (2015). Conference Report, https://doi.org/10.1016/j.jcf.2015.10.001

Vezzoli, V., P. Duminuco, A. Vottero, G. Kleinau, R. Schülein, R. Minari, I. Bassi, S. Bernasconi, L. Persani, M. Bonomi, A newvariant in signal peptide of the human luteinizing hormone receptor (LHCGR) affects receptor biogenesis causing leydig cell hypoplasia. Hum Mol Genet24, 6003-6012 (2015). https://doi.org/10.1093/hmg/ddv313

Voget, M., D. Lorenz, E. Lieber-Tenorio, R. Hauck, M. Meyer, M. Cieslicki, Is transmission electron microscopy (TEM) a promising approach for qualitative and quantitative investigations of polymyxin B and miconazole interactions with cellular and subcellular structures of Staphylococcus pseudintermedius, Escherichia coli, Pseudomonas aeruginosa and Malassezia pachydermatis? Vet Microbiol181, 261-270 (2015). https://doi.org/10.1016/j.vetmic.2015.10.002

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Wang, Y., M. D. V. Moreira, S. Heringer-Walther, H. P. Schultheiss, W. E. Siems, N. Wessel, T. Walther, Beta Blockers Prevent Correlation of Plasma ACE2 Activity With Echocardiographic Parameters in Patients With Idiopathic Dilated Cardiomyopathy. J Cardiovasc Pharm65, 8-12 (2015). https://doi.org/Doi 10.1097/Fjc.0000000000000156

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Williams, C., L. Opalinski, C. Landgraf, J. Costello, M. Schrader, A. M. Krikken, K. Knoops, A. M. Kram, R. Volkmer, J. van der Klei, The membrane remodeling protein Pex11p activates the GTPase Dnm1p during peroxisomal fission. Proc Natl Acad Sci USA112, 6377-6382 (2015). https://doi.org/10.1073/pnas.1418736112

Witte§, C., V. Martos§, H. M. Rose, S. Reinke, S. Klippel, L. Schröder*, C. P. R. Hackenberger*, Live-cell MRI with Xenon Hyper-CEST Biosensors Targeted to Metabolically Labeled Cell-Surface Glycans. Angew Chem Int Ed54, 2806-2810 (2015). https://doi.org/10.1002/anie.201410573

Wu, Y. J., R. Tejero, M. Arancillo, G. Vardar, T. Korotkova, M. Kintscher, D. Schmitz, A. Ponomarenko, L. Tabares, C. Rosenmund, Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions. J Neurophysiol114, 2404-2417 (2015). https://doi.org/10.1152/jn.00577.2015

Zevenbergen, C., M. E. Meima, E. C. L. de Souza, R. P. Peeters, A. Kinne, G. Krause, W. E. Visser, T. J. Visser, Transport of Iodothyronines by Human L-Type Amino Acid Transporters. Endocrinology156, 4345-4355 (2015). https://doi.org/10.1210/en.2015-1140

Zhang*§, J. J., C. Ni§, Z. G. Yang§, A. Piontek, H. P. Chen, S. J. Wang, Y. M. Fan, Z. H. Qin, J. Piontek, Specific binding of Clostridium perfringens enterotoxin fragment to Claudin-b and modulation of zebrafish epidermal barrier. Exp Dermatol24, 605-610 (2015). https://doi.org/10.1111/exd.12728

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