Publications

Publications 2017

§, # equal contribution; * corresponding author(s); bold: FMP members

Anumala, U. R., J. Waaler, Y. Nkizinkiko, A. Ignatev, K. Lazarow, P. Lindemann, P. A. Olsen, S. Murthy, E. Obaii, A. G. Majouga, S. Leonov, J. P. von Kries, L. Lehtio, S. Krauss*, M. Nazaré*, Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach. J Med Chem60, 10013-10025 (2017). https://doi.org/10.1021/acs.jmedchem.7b00883

Appelt-Menzel, A., A. Cubukova, K. Günther, F. Edenhofer, J. Piontek, G. Krause, T. Stüber, H. Walles, W. Neuhaus, M. Metzger, Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells. Stem Cell Rep8, 894-906 (2017). https://doi.org/10.1016/j.stemcr.2017.02.021

Arra, A., H. Lingel, B. Kuropka, J. Pick, T. Schnoeder, T. Fischer, C. Freund, M. Pierau, M. C. Brunner-Weinzierl, The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs. Oncoimmunology6, e1273300 (2017). https://doi.org/10.1080/2162402X.2016.1273300

Barskiy, D. A., A. M. Coffey, P. Nikolaou, D. M. Mikhaylov, B. M. Goodson, R. T. Branca, G. J. Lu, M. G. Shapiro, V. V. Telkki, V. V. Zhivonitko, I. V. Koptyug, O. G. Salnikov, K. V. Kovtunov, V. I. Bukhtiyarov, M. S. Rosen, M. J. Barlow, S. Safavi, I. P. Hall, L. Schröder, E. Y. Chekmenev*, NMR Hyperpolarization Techniques of Gases. Chemistry23, 725-751 (2017). https://doi.org/10.1002/chem.201603884

Baumholtz, A. I., A. Simard, E. Nikolopoulou, M. Oosenbrug, M. M. Collins, A. Piontek, G. Krause, J. Piontek, N. D. E. Greene, A. K. Ryan, Claudins are essential for cell shape changes and convergent extension movements during neural tube closure. Dev Biol428, 25-38 (2017). https://doi.org/10.1016/j.ydbio.2017.05.013

Berger, T. K., D. Fusshöller, N. Goodwin, W. Bönigk, A. Müller, N. D. Khesroshahi, C. Brenker, D. Wachten, E. Krause, U. B. Kaupp, T. Strünker*, Post-translational cleavage of Hv1 in human sperm tunes pH- and voltage-dependent gating. J Physiol-London595, 1533-1546 (2017). https://doi.org/10.1113/Jp273189

Blenau, W., D. Stöppler, S. Balfanz, M. Thamm, A. Baumann, Dm5-HT2B: Pharmacological Characterization of the Fifth Serotonin Receptor Subtype of Drosophila melanogaster. Front Syst Neurosci11, 28 (2017). https://doi.org/10.3389/fnsys.2017.00028

Blex, C., S. Michaelis, A. K. Schrey, J. Furkert, J. Eichhorst, K. Bartho, F. Gyapon Quast, A. Marais, M. Hakelberg, U. Gruber, S. Niquet, O. Popp, F. Kroll, M. Sefkow, R. Schülein, M. Dreger*, H. Köster, Targeting G Protein-Coupled Receptors by Capture Compound Mass Spectrometry: A Case Study with Sertindole. ChemBioChem18, 1639-1649 (2017). https://doi.org/10.1002/cbic.201700152

Bodrikov, V., A. Pauschert, G. Kochlamazashvili, C. A. O. Stuermer, Reggie-1 and reggie-2 (flotillins) participate in Rab11a-dependent cargo trafficking, spine synapse formation and LTP-related AMPA receptor (GluA1) surface exposure in mouse hippocampal neurons. Exp Neurol289, 31-45 (2017). https://doi.org/10.1016/j.expneurol.2016.12.007

Bormann, N., A. Koliszak, S. Kasper, L. Schoen, K. Hilpert, R. Volkmer, J. Kikhney, B. Wildemann, A short artificial antimicrobial peptide shows potential to prevent or treat bone infections. Sci Rep7, 1506 (2017). https://doi.org/10.1038/s41598-017-01698-0

Carter, D. M., E. Specker, J. Przygodda, M. Neuenschwander, J. P. von Kries, U. Heinemann, M. Nazare*, U. Gohlke, Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells. Slas Discov22, 801-812 (2017). https://doi.org/10.1177/2472555217699157

Carus-Cadavieco§, M., M. Gorbati§, L. Ye, F. Bender, S. van der Veldt, C. Kosse, C. Borgers, S. Y. Lee, C. Ramakrishnan, Y. B. Hu, N. Denisova, F. Ramm, E. Volitaki, D. Burdakov, K. Deisseroth, A. Ponomarenko*, T. Korotkova*, Gamma oscillations organize top-down signalling to hypothalamus and enable food seeking. Nature542, 232-236 (2017). https://doi.org/10.1038/nature21066

Chen, S., S. E. Palma-Vera, M. Langhammer, S. P. Galuska, B. C. Braun, E. Krause, A. Lucas-Hahn, J. Schoen, An air-liquid interphase approach for modeling the early embryo-maternal contact zone. Sci Rep7, 42298 (2017). https://doi.org/10.1038/srep42298

Chenge, J. T., L. V. Duyet, S. Swami, K. J. McLean, M. E. Kavanagh, A. G. Coyne, S. E. J. Rigby, M. R. Cheesman, H. M. Girvan, C. W. Levy, B. Rupp, J. P. von Kries, C. Abell, D. Leys, A. W. Munro, Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1. J Biol Chem292, 1310-1329 (2017). https://doi.org/10.1074/jbc.M116.748822

Chevelkov, V., K. Giller, S. Becker, A. Lange, Measurement of backbone hydrogen-deuterium exchange in the type III secretion system needle protein PrgI by solid-state NMR. J Magn Reson283, 110-116 (2017). https://doi.org/10.1016/j.jmr.2017.08.012

Cording§, J., B. Arslan§, C. Staat, S. Dithmer, S. M. Krug, A. Krüger, P. Berndt, R. Günther, L. Winkler, I. E. Blasig, R. F. Haseloff, Trictide, a tricellulin-derived peptide to overcome cellular barriers. Ann Ny Acad Sci1405, 89-101 (2017). doi.org/10.1111/nyas.13392

Dithmer, S., C. Staat, C. Müller, M. C. Ku, A. Pohlmann, T. Niendorf, N. Gehne, P. Fallier-Becker, A. Kittel, F. R. Walter, S. Veszelka, M. A. Deli, R. Blasig, R. F. Haseloff, I. E. Blasig, L. Winkler, Claudin peptidomimetics modulate tissue barriers for enhanced drug delivery. Ann Ny Acad Sci1397, 169-184 (2017). https://doi.org/10.1111/nyas.13359

Du, J., M. Neuenschwander, Y. Yu, J. H. M. Dabritz, N. R. Neuendorff, K. Schleich, A. Bittner, M. Milanovic, G. Beuster, S. Radetzki, E. Specker, M. Reimann, F. Rosenbauer, S. Mathas, P. Lohneis, M. Hummel, B. Dorken, J. P. von Kries, S. Lee, C. A. Schmitt, Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma. Blood129, 71-81 (2017). https://doi.org/10.1182/blood-2016-02-700773

Eichmann, C., S. Bibow, R. Riek, alpha-Synuclein lipoprotein nanoparticles. Nanotechnol Rev6, 105-110 (2017). Review, https://doi.org/10.1515/ntrev-2016-0062

Eichmann§, C., P. Kumari§, R. Riek, High-density lipoprotein-like particle formation of Synuclein variants. FEBS Lett591, 304-311 (2017). https://doi.org/10.1002/1873-3468.12543

Eichner, M., J. Protze, A. Piontek, G. Krause, J. Piontek, Targeting and alteration of tight junctions by bacteria and their virulence factors such as Clostridium perfringens enterotoxin. Pflug Arch Eur J Phy469, 77-90 (2017). Review, https://doi.org/10.1007/s00424-016-1902-x

Erlendsson, S., K. Gotfryd, F. H. Larsen, J. S. Mortensen, M. A. Geiger, B. J. van Rossum, H. Oschkinat, U. Gether, K. Teilum, C. J. Loland, Direct assessment of substrate binding to the Neurotransmitter: Sodium Symporter LeuT by solid state NMR. Elife6, e19314 (2017). https://doi.org/10.7554/eLife.19314

Exner, M. P., T. Kuenz , T. M. T. To, Z. F. Ouyan , S. Schwagerus, M. G. Hoesl, C. P. R. Hackenberger, M. C. Lensen, S. Panke, N. Budisa, Design of S-Allylcysteine in Situ Production and Incorporation Based on a Novel Pyrrolysyl-tRNA Synthetase Variant. Chembiochem18, 85-90 (2017). https://doi.org/10.1002/cbic.201600537

Fetzer, C., V. S. Korotkov, R. Thanert, K. M. Lee, M. Neuenschwander, J. P. von Kries, E. Medina, S. A. Sieber, A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug-Resistant Staphylococcus aureus. Angew Chem Int Ed56, 15746-15750 (2017). https://doi.org/10.1002/anie.201708454

Franca, J. A. A., A. Navarro-Vazquez, X. X. Lei, H. Sun, C. Griesinger, F. Hallwass, Complete NMR assignment and conformational analysis of 17-alpha-ethinylestradiol by using RDCs obtained in grafted graphene oxide. Magn Reson Chem55, 297-303 (2017). https://doi.org/10.1002/mrc.4526

Fricke, P., V. Chevelkov*, M. Zinke, K. Giller, S. Becker, A. Lange*, Backbone assignment of perdeuterated proteins by solid-state NMR using proton detection and ultrafast magic-angle spinning. Nat Protoc12, 764-782 (2017). https://doi.org/10.1038/nprot.2016.190

Fukuoka, A., G. Gasser, D. Guldi, C. Hackenberger, T. Hisatomi, P. Knochel, J. Kubota, S. Matile, F. Wuerthner, J. Yoon, Outstanding Reviewers for Chemical Science in 2016. Chem Sci8, 4158-4158 (2017). Editorial, https://doi.org/10.1039/c7sc90023f

Gehne, N., A. Lamik, M. Lehmann, R. F. Haseloff, A. V. Andjelkovic, I. E. Blasig, Cross-over endocytosis of claudins is mediated by interactions via their extracellular loops. PLoS One12, e0182106 (2017). https://doi.org/10.1371/journal.pone.0182106

Geithe, C., J. Protze, F. Kreuchwig, G. Krause*, D. Krautwurst*, Structural determinants of a conserved enantiomer-selective carvone binding pocket in the human odorant receptor OR1A1. Cell Mol Life Sci74, 4209-4229 (2017). https://doi.org/10.1007/s00018-017-2576-z

Gerth§, F., M. Jäpel§, A. Pechstein, G. Kochlamazashvili, M. Lehmann, D. Puchkov, F. Onofri, F. Benfenati, A. G. Nikonenko, K. Fredrich, O. Shupliakov, T. Maritzen, C. Freund, V. Haucke, Intersectin associates with synapsin and regulates its nanoscale localization and function. Proc Natl Acad Sci USA114, 12057-12062 (2017). https://doi.org/10.1073/pnas.1715341114

Gibert, A., M. Lehmann, B. Wiesner, R. Schülein, in G-Protein-Coupled Receptor Dimers, K. Herrick-Davis, G. Milligan, G. Di Giovanni, Eds. (Springer International Publishing, 2017), pp. 359-384. Book Chapter

Gimenez-Mascarell, P., I. Oyenarte, S. Hardy, T. Breiderhoff, M. Stuiver, E. Kostantin, T. Diercks, A. L. Pey, J. Ereno-Orbea, M. L. Martinez-Chantar, R. Khalaf-Nazzal, F. Claverie-Martin, D. Müller, M. L. Tremblay, L. A. Martinez-Cruz, Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2. J Biol Chem292, 786-801 (2017). https://doi.org/10.1074/jbc.M116.759944

Griger, J. C., R. B. Schneider, L. Lahmann, V. Schöwel, C. Keller, S. Spuler, M. Nazaré, C. Birchmeier, Loss of Ptpn11 (Shp2) drives satellite cells into quiescence. Elife6, e21552 (2017). https://doi.org/10.7554/eLife.21552

Hartl, M., M. Fussl, P. J. Boersema, J. O. Jost, K. Kramer, A. Bakirbas, J. Sindlinger, M. Plochinger, D. Leister, G. Uhrig, G. B. G. Moorhead, J. Cox, M. E. Salvucci, D. Schwarzer, M. Mann, I. Finkemeier, Lysine acetylome profiling uncovers novel histone deacetylase substrate proteins in Arabidopsis. Mol Syst Biol13, 949 (2017). https://doi.org/10.15252/msb.20177819

Hauser, A., M. Penkert, C. P. R. Hackenberger, Chemical Approaches to Investigate Labile Peptide and Protein Phosphorylation. Accounts of Chemical Research50, 1883-1893 (2017). Review, https://doi.org/10.1021/acs.accounts.7b00170

Hennings, J. C., O. Andrini, N. Picard, M. Paulais, A. K. Huebner, I. K. L. Cayuqueo, Y. Bignon, M. Keck, N. Corniere, D. Böhm, T. J. Jentsch, R. Chambrey, J. Teulon, C. A. Hübner, D. Eladari, The CIC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron. J Am Soc Nephrol28, 209-217 (2017). https://doi.org/10.1681/Asn.2016010085

Herce§*, H. D., D. Schumacher§*, A. F. L. Schneider, A. K. Ludwig, F. A. Mann, M. Fillies, M. A. Kasper, S. Reinke, E. Krause, H. Leonhardt, M. C. Cardoso*, C. P. R. Hackenberger*, Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells. Nat Chem9, 762-771 (2017). https://doi.org/10.1038/Nchem.2811

Herrera, C. G., A. Ponomarenko, T. Korotkova, D. Burdakov, A. Adamantidis, Sleep & metabolism: The multitasking ability of lateral hypothalamic inhibitory circuitries. Front Neuroendocrin44, 27-34 (2017). Review, https://doi.org/10.1016/j.yfrne.2016.11.002

Hinderlich, S., M. Neuenschwander*, P. R. Wratil, A. Oder, M. Lisurek, L. D. Nguyen, J. P. von Kries, C. P. R. Hackenberger*, Small Molecules Targeting Human N-Acetylmannosamine Kinase. ChemBioChem18, 1279-1285 (2017). https://doi.org/10.1002/cbic.201700066

Hinderlich, S., R. Tauber, C. R. Bertozzi, C. P. R. Hackenberger, Werner Reutter: A Visionary Pioneer in Molecular Glycobiology. Chembiochem18, 1141-1145 (2017). Editorial, https://doi.org/10.1002/cbic.201700277

Hinz, K. M., D. Neef, C. Rutz, J. Furkert, J. Kafirle, R. Schülein, G. Krause, Molecular features of the L-type amino acid transporter 2 determine different import and export profiles for thyroid hormones and amino acids. Mol Cell Endocrinol443, 163-174 (2017). https://doi.org/10.1016/j.mce.2017.01.024

Igual Gil, C., M. Jarius, J. P. von Kries, A. K. Rohlfing, Neuronal Chemosensation and Osmotic Stress Response Converge in the Regulation of aqp-8 in C. elegans. Front Physiol8, 380 (2017). https://doi.org/10.3389/fphys.2017.00380

Jakob, B., G. Kochlamazashvili, M. Jäpel, A. Gauhar, H. H. Bock, T. Maritzen, V. Haucke, Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus. Proc Natl Acad Sci USA114, 5533-5538 (2017). https://doi.org/10.1073/pnas.1704447114

Juling, S., A. Niedzwiecka, L. Böhmert, D. Lichtenstein, S. Selve, A. Braeuning, A. F. Thünemann, E. Krause, A. Lampen, Protein Corona Analysis of Silver Nanoparticles Links to Their Cellular Effects. J Proteome Res16, 4020-4034 (2017). https://doi.org/10.1021/acs.jproteome.7b00412

Juneja, M., D. Kobelt, W. Walther, C. Voss, J. Smith, E. Specker, M. Neuenschwander, B. O. Gohlke, M. Dahlmann, S. Radetzki, R. Preissner, J. P. von Kries, P. M. Schlag, U. Stein, Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1. PLoS Biol15, e2000784 (2017). https://doi.org/10.1371/journal.pbio.2000784

Kaempf, N., T. Maritzen, Safeguards of Neurotransmission: Endocytic Adaptors as Regulators of Synaptic Vesicle Composition and Function. Front Cell Neurosci11, 320 (2017). Review, https://doi.org/10.3389/fncel.2017.00320

Kirstein, J., K. Arnsburg, A. Scior, A. Szlachcic, D. L. Guilbride, R. I. Morimoto, B. Bukau, N. B. Nillegoda, In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging. Aging Cell16, 1414-1424 (2017). https://doi.org/10.1111/acel.12686

Kissing§, S., S. Rudnik§, M. Damme, R. Lullmann-Rauch, A. Ichihara, U. Kornak, E. L. Eskelinen, S. Jabs, J. Heeren, J. K. De Brabander, A. Haas, P. Saftig, Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes. Autophagy13, 670-685 (2017). https://doi.org/10.1080/15548627.2017.1280216

Kleinau, G., C. L. Worth, A. Kreuchwig, H. Biebermann, P. Marcinkowski, P. Scheerer, G. Krause, Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at work. Front Endocrinol8, 86 (2017). Review, https://doi.org/10.3389/fendo.2017.00086

Kononenko§*, N. L., G. A. Classen§, M. Kuijpers, D. Puchkov, T. Maritzen, A. Tempes, A. R. Malik, A. Skalecka, S. Bera, J. Jaworski, V. Haucke*, Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration. Nat Commun8, 14819 (2017). https://doi.org/10.1038/ncomms14819

Krause*, G., K. M. Hinz, Thyroid hormone transport across L-type. amino acid transporters: What can molecular modelling tell us? Mol Cell Endocrinol458, 68-75 (2017). Review, https://doi.org/10.1016/j.mce.2017.03.018

Kumar, A., C. Manatschal, A. Rai, I. Grigoriev, M. S. Degen, R. Jaussi, I. Kretzschmar, A. E. Prota, R. Volkmer, R. A. Kammerer, A. Akhmanova, M. O. Steinmetz, Short Linear Sequence Motif LxxPTPh Targets Diverse Proteins to Growing Microtubule Ends. Structure25, 924-932 (2017). https://doi.org/10.1016/j.str.2017.04.010

Lakshmanan, A., G. J. Lu, A. Farhadi, S. P. Nety, M. Kunth, A. Lee-Gosselin, D. Maresca, R. W. Bourdeau, M. Yin, J. Yan, C. Witte, D. Malounda, F. S. Foster, L. Schröder, M. G. Shapiro, Preparation of biogenic gas vesicle nanostructures for use as contrast agents for ultrasound and MRI. Nat Protoc12, 2050-2080 (2017). https://doi.org/10.1038/nprot.2017.081

Lauster§, D., M. Glanz§, M. Bardua, K. Ludwig, M. Hellmund, U. Hoffmann, A. Hamann, C. Böttcher, R. Haag, C. P. R. Hackenberger*, A. Herrmann*, Multivalent Peptide-Nanoparticle Conjugates for Influenza-Virus Inhibition. Angew Chem Int Ed56, 5931-5936 (2017). https://doi.org/10.1002/anie.201702005

Lechler, M. C., E. D. Crawford, N. Groh, K. Widmaier, R. Jung, J. Kirstein, J. C. Trinidad, A. L. Burlingame, D. C. David, Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging. Cell Rep18, 454-467 (2017). https://doi.org/10.1016/j.celrep.2016.12.033

Lei, X. X., F. Qiu, H. Sun, L. W. Bai, W. X. Wang, W. S. Xiang, H. P. Xiao, A Self-Assembled Oligopeptide as a Versatile NMR Alignment Medium for the Measurement of Residual Dipolar Couplings in Methanol. Angew Chem Int Ed56, 12857-12861 (2017). https://doi.org/10.1002/anie.201705123

Leipold, E., F. Ullrich, M. Thiele, A. A. Tietze, H. Terlau, D. Imhof, S. H. Heinemann, Subtype-specific block of voltage-gated K+ channels by mu-conopeptides. Biochem Biophys Res Commun482, 1135-1140 (2017). https://doi.org/10.1016/j.bbrc.2016.11.170

Leonhardt, J., D. C. Villela, A. Teichmann, L. M. Münter, M. C. Mayer, M. Mardahl, S. Kirsch, P. Namsolleck, K. Lucht, V. Benz, N. Alenina, N. Daniell, M. Horiuchi, M. Iwai, G. Multhaup, R. Schülein, M. Bader, R. A. Santos, T. Unger, U. M. Steckelings, Evidence for Heterodimerization and Functional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS. Hypertension69, 1128-1135 (2017). https://doi.org/10.1161/Hypertensionaha.116.08814

Li, G. W., J. M. Cao, W. Zong, L. Hu, M. L. Hu, X. X. Lei*, H. Sun*, R. X. Tan*, Helical Polyisocyanopeptides as Lyotropic Liquid Crystals for Measuring Residual Dipolar Couplings. Chemistry23, 7653-7656 (2017). https://doi.org/10.1002/chem.201700539

Liokatis, S., Reconstitution of Nucleosomes with Differentially Isotope-labeled Sister Histones. Jove-J Vis Exp2017, e55349 (2017). https://doi.org/10.3791/55349

Liu, Q. Y., S. Remmelzwaal, A. J. R. Heck, A. Akhmanova*, F. Liu*, Facilitating identification of minimal protein binding domains by cross-linking mass spectrometry. Sci Rep7, 13453 (2017). https://doi.org/10.1038/s41598-017-13663-y

Liu§*, F., P. Lössl§, R. Scheltema, R. Viner, A. J. R. Heck, Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification. Nat Commun8, 15473 (2017). https://doi.org/10.1038/ncomms15473

Lo§, W. T., A. Vujicic Zagar§, F. Gerth§, M. Lehmann, D. Puchkov, O. Krylova, C. Freund, L. Scapozza, O. Vadas*, V. Haucke*, A Coincidence Detection Mechanism Controls PX-BAR Domain-Mediated Endocytic Membrane Remodeling via an Allosteric Structural Switch. Dev Cell43, 522-529 (2017). https://doi.org/10.1016/j.devcel.2017.10.019

Lorenz, C., P. Lesimple, R. Bukowiecki, A. Zink, G. Inak, B. Mlody, M. Singh, M. Semtner, N. Mah, K. Aure, M. Leong, O. Zabiegalov, E. M. Lyras, V. Pfiffer, B. Fauler, J. Eichhorst, B. Wiesner, N. Huebner, J. Priller, T. Mielke, D. Meierhofer, Z. Izsvak, J. C. Meier, F. Bouillaud, J. Adjaye, M. Schuelke, E. E. Wanker, A. Lombes*, A. Prigione*, Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders. Cell Stem Cell20, 659-674 (2017). https://doi.org/10.1016/j.stem.2016.12.013

Lutter, D., F. Ullrich, J. C. Lueck, S. Kempa, T. J. Jentsch, Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels. J Cell Sci130, 1122-1133 (2017). https://doi.org/10.1242/jcs.196253

Ma, F. H., X. Wang, J. L. Chen, X. Wen, H. Sun*, X. C. Su*, Deciphering the Multisite Interactions of a Protein and Its Ligand at Atomic Resolution by Using Sensitive Paramagnetic Effects. Chemistry23, 926-934 (2017). https://doi.org/10.1002/chem.201604393

Marat§, A. L., A. Wallroth§, W. T. Lo, R. Müller, G. D. Norata, M. Falasca, C. Schultz, V. Haucke, mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate. Science356, 968-972 (2017). https://doi.org/10.1126/science.aaf8310

Marmelstein§, A. M., J. Moreno§, D. Fiedler, Chemical Approaches to Studying Labile Amino Acid Phosphorylation. Top Curr Chem (Cham)375, 22 (2017). Review, https://doi.org/10.1007/s41061-017-0111-1

Marter, K., J. Wetzel, J. Eichhorst, N. Eremina, G. Leboulle, A. Barth, B. Wiesner, D. Eisenhardt, Inhibition of Protein Synthesis with Highly Soluble Caged Compounds. Chemistryselect2, 6212-6217 (2017). https://doi.org/10.1002/slct.201701175

Mertins, P., D. Przybylski, N. Yosef, J. N. Qiao, K. Clauser, R. Raychowdhury, T. M. Eisenhaure, T. Maritzen, V. Haucke, T. Satoh, S. Akira, S. A. Carr, A. Regev, N. Hacohen, N. Chevrier, An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling. Cell Rep19, 2853-2866 (2017). https://doi.org/10.1016/j.celrep.2017.06.016

Minge, D., O. Senkov, R. Kaushik, M. K. Herde, O. Tikhobrazova, A. B. Wulff, A. Mironov, T. H. van Kuppevelt, A. Oosterhof, G. Kochlamazashvili, A. Dityatev, C. Henneberger, Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination. Cereb Cortex27, 903-918 (2017). https://doi.org/10.1093/cercor/bhx003

Moreno, J., L. Grubert, J. Schwarz, D. Bleger, S. Hecht, Efficient Sensitized Z -> E Photoisomerization of an Iridium(III)-Azobenzene Complex over a Wide Concentration Range. Chemistry23, 14090-14095 (2017). https://doi.org/10.1002/chem.201703376

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Piontek§, A., C. Witte§, H. M. Rose, M. Eichner§, J. Protze, G. Krause, J. Piontek*, L. Schröder*, A cCPE-based xenon biosensor for magnetic resonance imaging of claudin-expressing cells. Ann Ny Acad Sci1397, 195-208 (2017). https://doi.org/10.1111/nyas.13363

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