Publications

Publications 2018

§, # equal contribution; * corresponding author(s); bold: FMP members

Abed, H. B., N. Weissing, J. Schoene, J. Paulus, N. Sewald, M. Nazaré, Novel strategy for the preparation of 3-perfluoroalkylated-2H-indazole derivatives. Tetrahedron Lett59, 1813-1815 (2018). https://doi.org/10.1016/j.tetlet.2018.03.051

Arellano, V. J., P. M. Garcia, J. G. R. Plaza, M. T. L. Ortiz, G. Schreiber, R. Volkmer, E. Klipp, G. Del Rio, An Antimicrobial Peptide Induces FIG1-Dependent Cell Death During Cell Cycle Arrest in Yeast. Front Microbiol9, 1240 (2018). https://doi.org/10.3389/fmicb.2018.01240

Aretz, J., U. R. Anumala, F. F. Fuchsberger, N. Molavi, N. Ziebart, H. X. Zhang*, M. Nazaré*, C. Rademacher*, Allosteric Inhibition of a Mammalian Lectin. J Am Chem Soc140, 14915-14925 (2018). https://doi.org/10.1021/jacs.8b08644

Ast, A., A. Buntru, F. Schindler, R. Hasenkopf, A. Schulz, L. Brusendorf, K. Klockmeier, G. Grelle, B. McMahon, H. Niederlechner, I. Jansen, L. Diez, J. Edel, A. Boeddrich, S. A. Franklin, B. Baldo, S. Schnoegl, S. Kunz, B. Purfürst, A. Gaertner, H. H. Kampinga, A. J. Morton, A. Petersen, J. Kirstein, G. P. Bates, E. E. Wanker, mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease. Mol Cell71, 675-688 (2018). https://doi.org/10.1016/j.molcel.2018.07.032

Azarnia Tehran§, D., M. Kuijpers§, V. Haucke, Presynaptic endocytic factors in autophagy and neurodegeneration. Curr Opin Neurobiol48, 153-159 (2018). Review, https://doi.org/10.1016/j.conb.2017.12.018

Azarnia Tehran*, D., M. Pirazzini*, Preparation of Cerebellum Granule Neurons from Mouse or Rat Pups and Evaluation of Clostridial Neurotoxin Activity and Their Inhibitors by Western Blot and Immunohistochemistry. Bio-Protocol8, e2918 (2018). https://doi.org/10.21769/BioProtoc.2918

Bagheri, M., M. Amininasab, M. Dathe, Arginine/Tryptophan-Rich Cyclic /-Antimicrobial Peptides: TheRoles of Hydrogen Bonding and Hydrophobic/Hydrophilic Solvent-Accessible Surface Areas upon Activity and Membrane Selectivity. Chemistry24, 14242-14253 (2018). Article https://doi.org/10.1002/chem.201802881

Baranovic, J., A. J. R. Plested, Auxiliary subunits keep AMPA receptors compact during activation and desensitization. Elife7, e40548 (2018). https://doi.org/10.7554/eLife.40548

Baumann, A. L., C. P. R. Hackenberger, Modern Ligation Methods to Access Natural and Modified Proteins. Chimia72, 802-808 (2018). Review, https://doi.org/10.2533/chimia.2018.802

Becker, M., A. Moore, M. Naughton, B. Boland, W. E. Siems, T. Walther, Neprilysin degrades murine Amyloid-beta (A beta) more efficiently than human A beta: Further implication for species-specific amyloid accumulation. Neurosci Lett686, 74-79 (2018). https://doi.org/10.1016/j.neulet.2018.08.028

Bender, F., T. Korotkova*, A. Ponomarenko*, Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice. Jove-J Vis Exp, e57349 (2018). https://doi.org/10.3791/57349

Böhme, M. A., A. T. Grasskamp, A. M. Walter, Regulation of synaptic release-site Ca2+ channel coupling as a mechanism to control release probability and short-term plasticity. FEBS Lett592, 3516-3531 (2018). Review, https://doi.org/10.1002/1873-3468.13188

Brennecke, P., M. I. Ferrante, I. A. Johnston, D. Smith, A Collaborative European Approach to Accelerating Translational Marine Science. J Mar Sci Eng6, 81 (2018). https://doi.org/10.3390/jmse6030081

Buhrke, T., L. Voss, A. Briese, H. Stephanowitz, E. Krause, A. Braeuning, A. Lampen, Oxidative inactivation of the endogenous antioxidant protein DJ-1 by the food contaminants 3-MCPD and 2-MCPD. Arch Toxicol92, 289-299 (2018). https://doi.org/10.1007/s00204-017-2027-5

Chiha, S., A. Soicke, M. Barone, M. Müller, J. Bruns, R. Opitz, J. M. Neudorfl, R. Kühne, H. G. Schmalz, Design and Synthesis of Building Blocks for PPII-Helix Secondary-Structure Mimetics: A Stereoselective Entry to 4-Substituted 5-Vinylprolines. Eur J Org Chem2018, 455-460 (2018). https://doi.org/10.1002/ejoc.201701584

Chow, W. Y., C. J. Forman, D. Bihan, A. M. Puszkarska, R. Rajan, D. G. Reid, D. A. Slatter, L. J. Colwell, D. J. Wales, R. W. Farndale, M. J. Duer, Proline provides site-specific flexibility for in vivo collagen. Sci Rep8, 13809 (2018). https://doi.org/10.1038/s41598-018-31937-x

Chow, W. Y., R. Li, I. Goldberga, D. G. Reid, R. Rajan, J. Clark, H. Oschkinat*, M. J. Duer*, R. Hayward, C. M. Shanahan, Essential but sparse collagen hydroxylysyl post-translational modifications detected by DNP NMR. Chem Commun54, 12570-12573 (2018). https://doi.org/10.1039/c8cc04960b

Cid, L. P., T. J. Jentsch, F. V. Sepulveda, Reply from L. P. Cid, T. J. Jentsch and F. V. Sepulveda: intestinal electrolyte and fluid secretion - a model in trouble? J Physiol-London596, 2465-2466 (2018). Letter, https://doi.org/10.1113/Jp276139

Czuban, M., S. Srinivasan, N. A. Yee, E. Agustin, A. Koliszak, E. Miller, I. Khan, I. Quinones, H. Noory, C. Motola, R. Volkmer, M. Di Luca, A. Trampuz*, M. Royzen*, J. M. M. Oneto*, Bio-Orthogonal Chemistry and Reloadable Biomaterial Enable Local Activation of Antibiotic Prodrugs and Enhance Treatments against Staphylococcus aureus Infections. ACS Central Sci4, 1624-1632 (2018). https://doi.org/10.1021/acscentsci.8b00344

Dema, A., F. Macaluso, F. Sgro, G. E. Berto, F. T. Bianchi, A. A. Chiotto, G. Pallavicini, F. Di Cunto, M. Gai, Citron kinase-dependent F-actin maintenance at midbody secondary ingression sites mediates abscission. J Cell Sci131, jcs209080 (2018). https://doi.org/10.1242/jcs.209080

Demers, J. P., P. Fricke, C. W. Shi, V. Chevelkov, A. Lange, Structure determination of supra-molecular assemblies by solid-state NMR: Practical considerations. Prog Nucl Mag Res Sp109, 51-78 (2018). Review, https://doi.org/10.1016/j.pnmrs.2018.06.002

Diehl§, A., Y. Roske§, L. Ball, A. Chowdhury, M. Hiller, N. Moliere, R. Kramer, D. Stöppler, C. L. Worth, B. Schlegel, M. Leidert, N. Cremer, N. Erdmann, D. Lopez, H. Stephanowitz, E. Krause, B. J. van Rossum, P. Schmieder, U. Heinemann*, K. Turgay*, U. Akbey, H. Oschkinat*, Structural changes of TasA in biofilm formation of Bacillus subtilis. Proc Natl Acad Sci USA115, 3237-3242 (2018). https://doi.org/10.1073/pnas.1718102115

Döpfert, J., M. Schnurr, M. Kunth, H. M. Rose, A. Hennig, L. Schröder, Time-resolved monitoring of enzyme activity with ultrafast Hyper-CEST spectroscopy. Magn Reson Chem56, 679-688 (2018). https://doi.org/10.1002/mrc.4702

Dovey, C. M., J. Diep, B. P. Clarke, A. T. Hale, D. E. McNamara, H. Y. Guo, N. W. Brown, J. Y. Cao, C. R. Grace, P. J. Gough, J. Bertin, S. J. Dixon, D. Fiedler, E. S. Mocarski, W. J. Kaiser, T. Moldoveanu, J. D. York, J. E. Carette, MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. Mol Cell70, 936-948 (2018). https://doi.org/10.1016/j.molcel.2018.05.010

Duro-Castano, A., N. H. Lim, I. Tranchant, M. Amoura, F. Beau, H. Wieland, O. Kingler, M. Herrmann, M. Nazaré, O. Plettenburg, V. Dive*, M. J. Vicent, H. Nagase, In Vivo Imaging of MMP-13 Activity Using a Specific Polymer-FRET Peptide Conjugate Detects Early Osteoarthritis and Inhibitor Efficacy. Adv Funct Mater28, 1802738 (2018). https://doi.org/10.1002/adfm.201802738

Ebner, M., V. Haucke, Mechanical signals regulate TORC2 activity. Nat Cell Biol20, 994-995 (2018). Editorial, https://doi.org/10.1038/s41556-018-0181-5

 

Eibl, C., A. J. R. Plested, AMPA receptors: mechanisms of auxiliary protein action. Curr Opin Physiol2, 84-91 (2018). Review, https://doi.org/10.1016/j.cophys.2017.12.009

Eichner, M., C. Augustin, A. Fromm, A. Piontek, W. Walther, R. Bucker, M. Fromm, G. Krause, J. D. Schulzke, D. Günzel, J. Piontek, In Colon Epithelia, Clostridium perfringens Enterotoxin Causes Focal Leaks by Targeting Claudins Which are Apically Accessible Due to Tight Junction Derangement. J Infect Dis217, 147-157 (2018). https://doi.org/10.1093/infdis/jix485

Farhadi, A., G. Ho, M. Kunth, B. Ling, A. Lakshmanan, G. J. Lu, R. W. Bourdeau, L. Schröder, M. G. Shapiro, Recombinantly Expressed Gas Vesicles as Nanoscale Contrast Agents for Ultrasound and Hyperpolarized MRI. Aiche J64, 2927-2933 (2018). https://doi.org/10.1002/aic.16138

Fernandes-Rosa*, F. L., G. Daniil, I. J. Orozco, C. Göppner, R. El Zein, V. Jain, S. Boulkroun, X. Jeunemaitre, L. Amar, H. Lefebvre, T. Schwarzmayr, T. M. Strom, T. J. Jentsch*, M. C. Zennaro*, A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism. Nat Genet50, 355-361 (2018). https://doi.org/10.1038/s41588-018-0053-8

Fischer, J., G. Kleinau, C. Rutz, D. Zwanziger, N. Khajavi, A. Müller, M. Rehders, K. Brix, C. L. Worth, D. Führer, H. Krude, B. Wiesner, R. Schülein*, H. Biebermann*, Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level. Cell Mol Life Sci75, 2227-2239 (2018). https://doi.org/10.1007/s00018-017-2728-1

Fleischer, I., F. Beuerle, T. Bach, C. P. R. Hackenberger, A. Walther, S. Herzon, U. T. Bornscheuer, T. Skrydstrup, ORCHEM Prizes for Ivana Fleischer and Florian Beuerle. Angew Chem Int Ed57, 11505-11506 (2018). News, https://doi.org/10.1002/anie.201808525

Fulterer§, A., T. F. M. Andlauer§, A. Ender§, M. Maglione§, K. Eyring, J. Woitkuhn, M. Lehmann, T. Matkovic-Rachid, J. R. P. Geiger, A. M. Walter, K. I. Nagel, S. J. Sigrist, Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses. Cell Rep23, 1259-1274 (2018). https://doi.org/10.1016/j.celrep.2018.03.126

Geiger, M. A., A. P. Jagtap, M. Kaushik, H. Sun, D. Stöppler, S. T. Sigurdsson*, B. Corzilius*, H. Oschkinat*, Efficiency of Water-Soluble Nitroxide Biradicals for Dynamic Nuclear Polarization in Rotating Solids at 9.4 T: bcTol-M and cyolyl-TOTAPOL as New Polarizing Agents. Chemistry24, 13485-13494 (2018). https://doi.org/10.1002/chem.201801251

Harmel, R., D. Fiedler, Features and regulation of non-enzymatic post-translational modifications. Nat Chem Biol14, 244-252 (2018). Review, https://doi.org/10.1038/Nchembio.2575

Haucke, V., M. M. Kozlov, Membrane remodeling in clathrin-mediated endocytosis. J Cell Sci131, jcs216812 (2018). Review, https://doi.org/10.1242/jcs.216812

Haucke*, V., M. Krauss, Identifying Small-Molecule Inhibitors of the Clathrin Terminal Domain. Methods Mol Biol1847, 51-64 (2018). Book Chapter, https://doi.org/10.1007/978-1-4939-8719-1_5

Helma, J., H. Leonhardt, C. P. R. Hackenberger, D. Schumacher, Tub-Tag Labeling; Chemoenzymatic Incorporation of Unnatural Amino Acids. Methods Mol Biol1728, 67-93 (2018). Book Chapter, https://doi.org/10.1007/978-1-4939-7574-7_4

Hussain, A., A. Pooryasin, M. Zhang, L. F. Loschek, M. La Fortezza, A. B. Friedrich, C. M. Blais, H. K. Ucpunar, V. A. Yepez, M. Lehmann, N. Gompel, J. Gagneur, S. J. Sigrist, I. C. Grunwald Kadow, Inhibition of oxidative stress in cholinergic projection neurons fully rescues aging-associated olfactory circuit degeneration in Drosophila. Elife7, e32018 (2018). https://doi.org/10.7554/eLife.32018

Iline-Vul, T., N. Adiram-Filiba, I. Matlahov, Y. Geiger, M. Abayev, K. Keinan-Adamsky, U. Akbey, H. Oschkinat, G. Goobes, Understanding the roles of functional peptides in designing apatite and silica nanomaterials biomimetically using NMR techniques. Curr Opin Colloid In33, 44-52 (2018). Review, https://doi.org/10.1016/j.cocis.2018.01.012

Jayapaul, J., L. Schröder, Complete Generation of a Xe-129 Biosensor on the Solid Support by Systematic Backbone Assembly. Bioconjugate Chem29, 4004-4011 (2018). https://doi.org/10.1021/acs.bioconjchem.8b00814

Jentsch, T. J., M. Pusch, Clc Chloride Channels and Transporters: Structure, Function, Physiology, and Disease. Physiol Rev98, 1493-1590 (2018). Review, https://doi.org/10.1152/physrev.00047.2017

Jiang, K., L. Faltova, S. S. Hua, G. Capitani, A. E. Prota, C. Landgraf, R. Volkmer, R. A. Kammerer, M. O. Steinmetz, A. Akhmanova, Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex. Structure26, 375-382 (2018). https://doi.org/10.1016/j.str.2017.12.017

Juenemann, K., A. H. P. Jansen, L. van Riel, R. Merkx, M. P. C. Mulder, H. An, A. Statsyuk, J. Kirstein, H. Ovaa, E. A. Reits, Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies. Sci Rep8, 1405 (2018). https://doi.org/10.1038/s41598-018-19538-0

Julio-Kalajzic, F., S. Villanueva, J. Burgos, M. Ojeda, L. P. Cid, T. J. Jentsch, F. V. Sepulveda, K-2P TASK-2 and KCNQ1-KCNE3 K+ channels are major players contributing to intestinal anion and fluid secretion. J Physiol-London596, 393-407 (2018). https://doi.org/10.1113/Jp275178

Kath, C., P. Goni-Oliver, R. Müller, C. Schultz, V. Haucke, B. Eickholt, J. Schmoranzer, PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules. PLoS One13, e0193257 (2018). https://doi.org/10.1371/journal.pone.0193257

Klein§, W., C. Rutz§, J. Eckhard, B. Provinciael, E. Specker, M. Neuenschwander, G. Kleinau, P. Scheerer, J. P. von Kries, M. Nazaré, K. Vermeire, R. Schülein, Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway. PLoS One13, e0208641 (2018). https://doi.org/10.1371/journal.pone.0208641

Korotkova, T., A. Ponomarenko, C. K. Monaghan, S. L. Poulter, F. Cacucci, T. Wills, M. E. Hasselmo, C. Lever, Reconciling the different faces of hippocampal theta: The role of theta oscillations in cognitive, emotional and innate behaviors. Neurosci Biobehav R85, 65-80 (2018). https://doi.org/10.1016/j.neubiorev.2017.09.004

Krause*, G., P. Marcinkowski, Intervention Strategies into Glycoprotein Hormone Receptors for Modulating (Mal-)function, with Special Emphasis on the TSH Receptor. Horm Metab Res50, 894-907 (2018). Review, https://doi.org/10.1055/a-0749-6528

Kunth§, M., G. J. Lu§, C. Witte, M. G. Shapiro*, L. Schröder*, Protein Nanostructures Produce Self-Adjusting Hyperpolarized Magnetic Resonance Imaging Contrast through Physical Gas Partitioning. Acs Nano12, 10939-10948 (2018). https://doi.org/10.1021/acsnano.8b04222

Li*, W. Y., N. M. O'Brien-Simpson*, J. A. Holden, L. Otvos, E. C. Reynolds, F. Separovic, M. A. Hossain, J. D. Wade*, Covalent conjugation of cationic antimicrobial peptides with a beta-lactam antibiotic core. Peptide Sci110,  (2018). https://doi.org/10.1002/pep2.24059

Limatola, A., C. Eichmann, R. S. Jacob, G. Ben-Nissan, M. Sharon, A. Binolfi*, P. Selenko*, Time-Resolved NMR Analysis of Proteolytic alpha-Synuclein Processing in vitro and in cellulo. Proteomics18, e1800056 (2018). https://doi.org/10.1002/pmic.201800056

Liss, M., M. H. Radke, J. Eckhard, M. Neuenschwander, V. Dauksaite, J. P. von Kries, M. Gotthardt, Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling. PLoS One13, e0198492 (2018). https://doi.org/10.1371/journal.pone.0198492

Liu, F., P. Lössl, B. M. Rabbitts, R. S. Balaban*, A. J. R. Heck*, The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Mol Cell Proteomics17, 216-232 (2018). https://doi.org/10.1074/mcp.RA117.000470

Liu, Y., L. L. Zhang, M. Nazaré, Q. Q. Yao, H. Y. Hu, A novel nitroreductase-enhanced MRI contrast agent and its potential application in bacterial imaging. Acta Pharm Sin B8, 401-408 (2018). https://doi.org/10.1016/j.apsb.2017.11.001

Lück, J. C., D. Puchkov, F. Ullrich, T. J. Jentsch, LRRC8/VRAC anion channels are required for late stages of spermatid development in mice. J Biol Chem293, 11796-11808 (2018). https://doi.org/10.1074/jbc.RA118.003853

Maani, N., N. Sabha, K. Rezai, A. Ramani, L. Groom, N. Eltayeb, F. Mayandadnejad, A. Pang, G. Russo, M. Brudno, V. Haucke, R. T. Dirksen, J. J. Dowling, Tamoxifen therapy in a murine model of myotubular myopathy. Nat Commun9, 4849 (2018). https://doi.org/10.1038/s41467-018-07057-5

Maares, M., C. Keil, S. Thomsen, D. Günzel, B. Wiesner, H. Haase, Characterization of Caco-2 cells stably expressing the protein-based zinc probe eCalwy-5 as a model system for investigating intestinal zinc transport. J Trace Elem Med Biol49, 296-304 (2018). https://doi.org/10.1016/j.jtemb.2018.01.004

Maritzen, T., V. Haucke, Coupling of exocytosis and endocytosis at the presynaptic active zone. Neurosci Res127, 45-52 (2018). Review, https://doi.org/10.1016/j.neures.2017.09.013

Marmelstein, A. M., J. A. M. Morgan, M. Penkert, D. T. Rogerson, J. W. Chin, E. Krause, D. Fiedler, Pyrophosphorylation via selective phosphoprotein derivatization. Chem Sci9, 5929-5936 (2018). https://doi.org/10.1039/c8sc01233d

Meyer, K., M. Kirchner, B. Uyar, J. Y. Cheng, G. Russo, L. R. Hernandez-Miranda, A. Szymborska, H. Zauber, I. M. Rudolph, T. E. Willnow, A. Akalin, V. Haucke, H. Gerhardt, C. Birchmeier, R. Kuhn, M. Krauss, S. Diecke, J. M. Pascual, M. Selbach, Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs. Cell175, 239-253 (2018). https://doi.org/10.1016/j.cell.2018.08.019

Münch, J., G. Billig, C. A. Hübner, T. Leinders-Zufall, F. Zufall, T. J. Jentsch, Ca2+-activated Cl- currents in the murine vomeronasal organ enhance neuronal spiking but are dispensable for male-male aggression. J Biol Chem293, 10392-10403 (2018). https://doi.org/10.1074/jbc.RA118.003153

Neuhaus§, W., A. Piontek§, J. Protze, M. Eichner§, A. Mahringer, E. A. Subileau, I. F. M. Lee, J. D. Schulzke, G. Krause*, J. Piontek*, Reversible opening of the blood-brain barrier by claudin-5-binding variants of Clostridium perfringens enterotoxin's claudin-binding domain. Biomaterials161, 129-143 (2018). https://doi.org/10.1016/j.biomaterials.2018.01.028

Otten, C., J. Knox, G. Boulday, M. Eymery, M. Haniszewski, M. Neuenschwander, S. Radetzki, I. Vogt, K. Hahn, C. De Luca, C. Cardoso, S. Hamad, C. I. Gil, P. Roy, C. Albiges-Rizo, E. Faurobert, J. P. von Kries, M. Campillos, E. Tournier-Lasserve, W. B. Derry, S. Abdelilah-Seyfried, Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations. EMBO Mol Med10, e9155 (2018). https://doi.org/10.15252/emmm.201809155

Palmer, E. E., T. Stuhlmann, S. Weinert, E. Haan, H. Van Esch, M. Holvoet, J. Boyle, M. Leffler, M. Raynaud, C. Moraine, H. van Bokhoven, T. Kleefstra, K. Kahrizi, H. Najmabadi, H. H. Ropers, M. R. Delgado, D. Sirsi, S. Golla, A. Sommer, M. P. Pietryga, W. K. Chung, J. Wynn, L. Rohena, E. Bernardo, D. Hamlin, B. M. Faux, D. K. Grange, L. Manwaring, J. Tolmie, S. Joss, J. M. Cobben, F. A. M. Duijkers, J. M. Goehringer, T. D. Challman, F. Hennig, U. Fischer, A. Grimme, V. Suckow, L. Musante, J. Nicholl, M. Shaw, S. P. Lodh, Z. Niu, J. A. Rosenfeld, P. Stankiewicz, T. J. Jentsch, J. Gecz, M. Field, V. M. Kalscheuer*, D. S. , De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females. Mol Psychiatr23, 222-230 (2018). https://doi.org/10.1038/mp.2016.135

Pellegrini, E., A. Desfosses, A. Wallmann, W. M. Schulze, K. Rehbein, P. Mas, L. Signor, S. Gaudon, G. Zenkeviciute, M. Hons, H. Malet, I. Gutsche, C. Sachse, G. Schoehn, H. Oschkinat, S. Cusack, RIP2 filament formation is required for NOD2 dependent NF-kappa B signalling. Nat Commun9, 4043 (2018). https://doi.org/10.1038/s41467-018-06451-3

Pirazzini, M., D. Azarnia Tehran, G. Zanetti, O. Rossetto, C. Montecucco, Hsp90 and Thioredoxin-Thioredoxin Reductase enable the catalytic activity of Clostridial neurotoxins inside nerve terminals. Toxicon147, 32-37 (2018). https://doi.org/10.1016/j.toxicon.2017.10.028

Plested, A. J. R., Leading the charge. Elife7, e37910 (2018). Editorial, https://doi.org/10.7554/eLife.37910

Rödiger, M., M. W. Werno, I. Wilhelmi, C. Baumeier, D. Hesse, N. Wettschureck, S. Offermanns, K. Song, M. Krauss, A. Schürmann, Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes. Mol Metab8, 167-179 (2018). https://doi.org/10.1016/j.molmet.2017.11.011

Ruess, D. A., G. J. Heynen, K. J. Ciecielski, J. Y. Ai, A. Berninger, D. Kabacaoglu, K. Görgülü, Z. Dantes, S. M. Wörmann, K. N. Diakopoulos, A. F. Karpathaki, M. Kowalska, E. Kaya-Aksoy, L. Song, E. A. Z. van der Laan, M. P. Lopez-Alberca, M. Nazaré, M. Reichert, D. Saur, M. M. Erkan, U. T. Hopt, B. Sainz, W. Birchmeier, R. M. Schmid, M. Lesina, H. Algül, Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med24, 954-960 (2018). https://doi.org/10.1038/s41591-018-0024-8

Sama, S., G. Jerz, P. Schmieder, J. F. Joseph, M. F. Melzig, A. Weng, Plant derived triterpenes from Gypsophila elegans M.Bieb. enable non-toxic delivery of gene loaded nanoplexes. J Biotechnol284, 131-139 (2018). https://doi.org/10.1016/j.jbiotec.2018.07.037

Santos de Freitas, M., R. R. Araghi, E. Brandenburg, J. Leiterer, F. Emmerling, K. Folmert, U. I. M. Gerling-Driessen, B. Bardiaux, C. Böttcher, K. Pagel, A. Diehl, H. von Berlepsch*, H. Oschkinat*, B. Koksch*, The protofilament architecture of a de novo designed coiled coil-based amyloidogenic peptide. J Struct Biol203, 263-272 (2018). https://doi.org/10.1016/j.jsb.2018.05.009

Schoene, J., H. Bel Abed, P. Schmieder, M. Christmann, M. Nazaré, A General One-Pot Synthesis of 2H-Indazoles Using an Organophosphorus-Silane System. Chemistry24, 9090-9100 (2018). https://doi.org/10.1002/chem.201800763

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