Publications
Publications 2019
§, # equal contribution; * corresponding author(s); bold: FMP members
Alex, A., V. Piano, S. Polley, M. Stuiver, S. Voss, G. Ciossani, K. Overlack, B. Voss, S. Wohlgemuth, A. Petrovic, Y. Wu, P. Selenko, A. Musacchio*, S. Maffini*, Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology. Elife8, e48287 (2019). https://doi.org/10.7554/eLife.48287
Apel§, C., M. A. Kasper§*, C. E. Stieger, C. P. R. Hackenberger*, M. Christmann*, Protein Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanal. Org Lett21, 10043-10047 (2019). https://doi.org/10.1021/acs.orglett.9b03982
Arrey, F., D. Löwe, S. Kuhlmann, P. Kaiser, P. Moura-Alves, G. Krishnamoorthy, L. Lozza, J. Maertzdorf, T. Skrahina, A. Skrahina, M. Gengenbacher, G. Nouailles*, S. H. E. Kaufmann, Humanized Mouse Model Mimicking Pathology of Human Tuberculosis for in vivo Evaluation of Drug Regimens. Front Immunol10, 89 (2019). doi.org/10.3389/fimmu.2019.00089
Artarini, A., M. Meyer, Y. J. Shin, K. Huber, N. Hilz, F. Bracher, D. Eros, L. Orfi, G. Keri, S. Goedert, M. Neuenschwander, J. von Kries, Y. Domovich-Eisenberg, N. Dekel, I. Szabadkai, M. Lebendiker, Z. Horvath, T. Danielie, O. Livnahe, O. Moncorge, R. Frise, W. Barclay, T. F. Meyer, A. Karlas, Regulation of influenza A virus mRNA splicing by CLK1. Antivir Res168, 187-196 (2019). https://doi.org/10.1016/j.antiviral.2019.06.003
Ayala, S., P. Genevaux, C. Hureau, P. Faller, (Bio)chemical Strategies To Modulate Amyloid-beta Self-Assembly. ACS Chem Neurosci10, 3366-3374 (2019). Review, https://doi.org/10.1021/acschemneuro.9b00239
Azarnia Tehran§, D., T. Lopez-Hernandez§, T. Maritzen, Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations. Cells8, 1345 (2019). Review, https://doi.org/134510.3390/cells8111345
Baumann, A. L., C. P. R. Hackenberger, Tag and release: strategies for the intracellular cleavage of protein conjugates. Curr Opin Chem Biol52, 39-46 (2019). Review, https://doi.org/10.1016/j.cbpa.2019.04.019
Beier, L. S., J. Rossa, S. Woodhouse, S. Bergmann, H. B. Kramer, J. Protze, M. Eichner, A. Piontek, S. Vidal-y-Sy, J. M. Brandner, G. Krause, N. Zitzmann, J. Piontek, Use of Modified Clostridium perfringens Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells. Int J Mol Sci20, 4774 (2019). https://doi.org/10.3390/ijms20194774
Berndt, P., L. Winkler*, J. Cording, O. Breitkreuz-Korff, A. Rex, S. Dithmer, V. Rausch, R. Blasig, M. Richter, A. Sporbert, H. Wolburg, I. E. Blasig, R. F. Haseloff*, Tight junction proteins at the blood-brain barrier: far more than claudin-5. Cell Mol Life Sci76, 1987-2002 (2019). https://doi.org/10.1007/s00018-019-03030-7
Bhukel, A., C. B. Beuschel, M. Maglione, M. Lehmann, G. Juhasz, F. Madeo, S. J. Sigrist, Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner. Nat Commun10, 1318 (2019). doi.org/10.1038/s41467-019-09262-2
Binger, K. J., M. Neukam, S. G. Tattikota, F. Qadri, D. Puchkov, D. M. Willmes, S. Wurmsee, S. Geisberger, R. Dechend, K. Raile, T. Kurth, G. Nguyen, M. N. Poy, M. Solimena, D. N. Müller, A. L. Birkenfeld, Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic beta cells. Proc Natl Acad Sci USA116, 19983-19988 (2019). https://doi.org/10.1073/pnas.1903678116
Birke, R., E. Krause, M. Schümann, I. E. Blasig, R. F. Haseloff, Quantitative Evaluation of Different Protein Fractions of Cerebrospinal Fluid Using (18)O Labeling. Methods Mol Biol2044, 119-128 (2019). Book Chapter, https://doi.org/10.1007/978-1-4939-9706-0_8
Bogdanow, B., X. Wang, K. Eichelbaum, A. Sadewasser, I. Husic, K. Paki, M. Budt, M. Hergeselle, B. Vetter, J. Hou, W. Chen, L. Wiebusch, I. M. Meyer, T. Wolff, M. Selbach, The dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant. Nat Commun10, 5518 (2019). https://doi.org/10.1038/s41467-019-13520-8
Böhme§, M. A., A. W. McCarthy§, A. T. Grasskamp, C. B. Beuschel, P. Goel, M. Jusyte, D. Laber, S. Huang, U. Rey, A. G. Petzoldt, M. Lehmann, F. Gottfert, P. Haghighi, S. W. Hell, D. Owald, D. Dickman, S. J. Sigrist*, A. M. Walter*, Rapid active zone remodeling consolidates presynaptic potentiation. Nat Commun10, 1085 (2019). https://doi.org/10.1038/s41467-019-08977-6
Brennecke, P., D. Rasina, O. Aubi, K. Herzog, J. Landskron, B. Cautain, F. Vicente, J. Quintana, J. Mestres, B. Stechmann, B. Ellinger, J. Brea, J. L. Kolanowski, R. Pilarski, M. Orzaez, A. Pineda-Lucena, L. Laraia, F. Nami, P. Zielenkiewicz, K. Paruch, E. Hansen, J. P. von Kries, M. Neuenschwander, E. Specker, P. Bartunek, S. Simova, Z. Lesnikowski, S. Krauss, L. Lehtio, U. Bilitewski, M. Bronstrup, K. Tasken, A. Jirgensons, H. Lickert, M. H. Clausen, J. H. Andersen, M. J. Vicent, O. Genilloud, A. Martinez, M. Nazaré, W. Fecke*, P. Gribbon*, EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology. Slas Discov24, 398-413 (2019). https://doi.org/10.1177/2472555218816276
Brinson, R. G., J. P. Marino, F. Delaglio, L. W. Arbogast, R. M. Evans, A. Kearsley, G. Gingras, H. Ghasriani, Y. Aubin, G. K. Pierens, X. Y. Jia, M. Mobli, H. G. Grant, D. W. Keizer, K. Schweimer, J. Stahle, G. Widmalm, E. R. Zartler, C. W. Lawrence, P. N. Reardon, J. R. Cort, P. Xu, F. Ni, S. Yanaka, K. Kato, S. R. Parnham, D. Tsao, A. Blomgren, T. Rundlof, N. Trieloff, P. Schmieder, A. Ross, K. Skidmore, K. Chen , D. Keire, D. I. Freedberg, T. Suter-Stahel, G. Wider, G. Ilc, J. Plavec, S. A. Bradley, D. M. Baldisseri, M. L. Sforca, A. C. D. Zeri, J. Y. Wei, C. M. Szabo, C. A. Amezcua, J. B. Jordan, M. Wikstrom, Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics. Mabs-Austin11, 94-105 (2019). https://doi.org/10.1080/19420862.2018.1544454
Brockmann§, M. M., M. Maglione§, C. G. Willmes§, A. Stumpf, B. A. Bouazza, L. M. Velasquez, M. K. Gräuel, P. Beed, M. Lehmann, N. Gimber, J. Schmoranzer, S. J. Sigrist, C. Rosenmund, D. Schmitz, RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses. Elife8, e43243 (2019). https://doi.org/10.7554/eLife.43243
Buntz, A., T. Killian, D. Schmid, H. Seul, U. Brinkmann, J. Ravn, M. Lindholm, H. Knoetgen, V. Haucke, O. Mundigl, Quantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression. Nucleic Acids Res47, 953-969 (2019). https://doi.org/10.1093/nar/gky1158
Castillo, X., S. Castro-Obregon, B. Gutierrez-Becker, G. Gutierrez-Ospina, N. Karalis, A. A. Khalil, J. S. Lopez-Noguerola, L. L. Rodriguez, E. Martinez-Martinez, C. Perez-Cruz, J. Perez-Velazquez, M. L. Pina, K. Rubio, H. P. S. Salazar Garcia, T. Syeda, A. Vanoye-Carlo, A. Villringeruo, K. Winek, M. Zille, Re-thinking the Etiological Framework of Neurodegeneration. Front Neurosci-Switz13, 728 (2019). Review, doi.org/10.3389/fnins.2019.00728
Chow, W. Y., Investigation of Triple-Helix Collagen Hydroxylation by Solid-State NMR Spectroscopy. Methods Mol Biol1944, 57-77 (2019). Book Chapter, doi.org/10.1007/978-1-4939-9095-5_5
Culemann, S., A. Grüneboom, J. A. Nicolas-Avila, D. Weidner, K. F. Lämmle, T. Rothe, J. A. Quintana, P. Kirchner, B. Krljanac, M. Eberhardt, F. Ferrazzi, E. Kretzschmar, M. Schicht, K. Fischer, K. Gelse, M. Faas, R. Pfeifle, J. A. Ackermann, M. Pachowsky, N. Renner, D. Simon, R. F. Haseloff, A. B. Ekici, T. Bäuerle, I. E. Blasig, J. Vera, D. Voehringer, A. Kleyer, F. Paulsen, G. Schett, A. Hidalgo, G. Krönke, Locally renewing resident synovial macrophages provide a protective barrier for the joint. Nature572, 670-675 (2019). https://doi.org/10.1038/s41586-019-1471-1
Dejonghe, W., I. Sharma, B. Denoo, S. De Munck, Q. Lu, K. Mishev, H. Bulut, E. Mylle, R. De Rycke, M. Vasileva, D. V. Savatin, W. Nerinckx, A. Staes, A. Drozdzecki, D. Audenaert, K. Yperman, A. Madder, J. Friml, D. Van Damme, K. Gevaert, V. Haucke, S. N. Savvides, J. Winne, E. Russinova, Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nat Chem Biol15, 641-649 (2019). https://doi.org/10.1038/s41589-019-0262-1
Driller, R., M. Ballaschk, P. Schmieder, B. Uchanska-Ziegler, A. Ziegler*, B. Loll*, Metal-triggered conformational reorientation of a self-peptide bound to a disease-associated HLA-B*27 subtype. J Biol Chem294, 13269-13279 (2019). https://doi.org/10.1074/jbc.RA119.008937
Driller, J. H., J. Lutzkendorf, H. Depner, M. Siebert, B. Kuropka, C. Weise, C. Piao, A. G. Petzoldt, M. Lehmann, U. Stelzl, R. Zahedi, A. Sickmann, C. Freund, S. J. Sigrist, M. C. Wahl, Phosphorylation of the Bruchpilot N-terminus in Drosophila unlocks axonal transport of active zone building blocks. J Cell Sci132, jcs225151 (2019). https://doi.org/10.1242/jcs.225151
Ebner, M., P. A. Koch, V. Haucke, Phosphoinositides in the control of lysosome function and homeostasis. Biochem Soc T47, 1173-1185 (2019). Review, https://doi.org/10.1042/Bst20190158
Feleciano, D. R., K. Juenemann, M. Iburg, I. C. Bras, C. I. Holmberg, J. Kirstein, Crosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease. Front Aging Neurosci11, 9 (2019). https://doi.org/10.3389/fnagi.2019.00009
Fred, S. M., L. Laukkanen, C. A. Brunello, L. Vesa, H. Goos, I. Cardon, R. Moliner, T. Maritzen, M. Varjosalo, P. C. Casarotto*, E. Castren, Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2. J Biol Chem294, 18150-18161 (2019). https://doi.org/10.1074/jbc.RA119.008837
Gerlach, M., T. Stoschek, H. Leonhardt, C. P. R. Hackenberger, D. Schumacher, J. Helma, Tubulin Tyrosine Ligase-Mediated Modification of Proteins. Methods Mol Biol2012, 327-355 (2019). Book Chapter, https://doi.org/10.1007/978-1-4939-9546-2_17
Gerth, F., M. Jäpel, J. Sticht, B. Kuropka, X. J. Schmitt, J. H. Driller, B. Loll, M. C. Wahl, K. Pagel, V. Haucke, C. Freund, Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain. Structure27, 977-987 (2019). https://doi.org/10.1016/j.str.2019.03.020
Goel, P., D. D. Bergeron, M. A. Böhme, L. Nunnelly, M. Lehmann, C. Buser, A. M. Walter, S. J. Sigrist, D. Dickman, Homeostatic scaling of active zone scaffolds maintains global synaptic strength. J Cell Biol218, 1706-1724 (2019). https://doi.org/10.1083/jcb.201807165
Gohlke, S., V. Zagoriy, A. C. Inostroza, M. Meret, C. Mancini, L. Japtok, F. Schumacher, D. Kuhlow, A. Graja, H. Stephanowitz, M. Jahnert, E. Krause, A. Wernitz, K. J. Petzke, A. Schürmann, B. Kleuser, T. J. Schulz, Identification of functional lipid metabolism biomarkers of brown adipose tissue aging. Mol Metab24, 1-17 (2019). https://doi.org/10.1016/j.molmet.2019.03.011
Goldberga, I., R. Li, W. Y. Chow, D. G. Reid, U. Bashtanova, R. Rajan, A. Puszkarska, H. Oschkinat*, M. J. Duer*, Detection of nucleic acids and other low abundance components in native bone and osteosarcoma extracellular matrix by isotope enrichment and DNP-enhanced NMR. Rsc Adv9, 26686-26690 (2019). https://doi.org/10.1039/c9ra03198g
Göppner§, C., I. J. Orozco§, M. B. Hoegg-Beiler, A. H. Soria, C. A. Hübner, F. L. Fernandes-Rosa, S. Boulkroun, M. C. Zennaro, T. J. Jentsch, Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism. Nat Commun10, 4678 (2019). https://doi.org/10.1038/s41467-019-12113-9
Gupta, R., H. L. Zhang, M. M. Lu, G. J. Hou, M. Caporini, M. Rosay, W. Maas, J. Struppe, J. Ahn, I. J. L. Byeon, H. Oschkinat, K. Jaudzems, E. Barbet-Massin, L. Emsley, G. Pintacuda*, A. Lesage*, A. M. Gronenborn*, T. Polenova*, Dynamic Nuclear Polarization Magic-Angle Spinning Nuclear Magnetic Resonance Combined with Molecular Dynamics Simulations Permits Detection of Order and Disorder in Viral Assemblies. J Phys Chem B123, 5048-5058 (2019). https://doi.org/10.1021/acs.jpcb.9b02293
Harmel§, R. K., R. Puschmann§, M. N. Trung, A. Saiardi, P. Schmieder, D. Fiedler, Harnessing C-13-labeled myo-inositol to interrogate inositol phosphate messengers by NMR. Chem Sci10, 5267-5274 (2019). https://doi.org/10.1039/c9sc00151d
Helbig§, I., T. Lopez-Hernandez§, O. Shor§, P. Galer, S. Ganesan, M. Pendziwiat, A. Rademacher, C. A. Ellis, N. Humpfer, N. Schwarz, S. Seiffert, J. Peeden, J. Shen, K. Sterbova, T. B. Hammer, R. S. Moller, D. N. Shinde, S. Tang, L. Smith, A. Poduri, R. Krause, F. Benninger#, K. L. Helbig#, V. Haucke#, Y. G. Weber*#, EuroEPINOMICS-RES Consortium, GRIN Consortium, A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy. Am J Hum Genet104, 1060-1072 (2019). https://doi.org/10.1016/j.ajhg.2019.04.001
Höfer, C. T., S. Di Lella, I. Dahmani, N. Jungnick, N. Bordag, S. Bobone, Q. Huang, S. Keller, A. Herrmann, S. Chiantia, Structural determinants of the interaction between influenza A virus matrix protein M1 and lipid membranes. Biochim Biophys Acta Biomembr1861, 1123-1134 (2019). https://doi.org/10.1016/j.bbamem.2019.03.013
Horsch, J., P. Wilke, H. Stephanowitz, E. Krause, H. G. Börner, Fish and Clips: A Convenient Strategy to Identify Tyrosinase Substrates with Rapid Activation Behavior for Materials Science Applications. ACS Macro Lett8, 724-729 (2019). https://doi.org/10.1021/acsmacrolett.9b00244
Hwang, S., P. Fricke, M. Zinke, K. Giller, J. S. Wall, D. Riedel, S. Becker, A. Lange, Comparison of the 3D structures of mouse and human alpha-synuclein fibrils by it solid-state NMR and STEM. J Struct Biol206, 43-48 (2019). https://doi.org/10.1016/j.jsb.2018.04.003
Hwang, S., C. Öster, V. Chevelkov, K. Giller, S. Lange, S. Becker, A. Lange, Characterization of H/D exchange in type 1 pili by proton-detected solid-state NMR and molecular dynamics simulations. J Biomol NMR73, 281-291 (2019). https://doi.org/10.1007/s10858-019-00247-3
Iacobucci, C., C. Piotrowski, R. Aebersold, B. C. Amaral, P. Andrews, K. Bernfur, C. Borchers, N. I. Brodie, J. E. Bruce, Y. Cao, S. Chaignepain, J. D. Chavez, S. Claverol, J. Cox, T. Davis, G. Degliesposti, M. Q. Dong, N. Edinger, C. Emanuelsson, M. Gay, M. Götze, F. Gomes-Neto, F. C. Gozzo, C. Gutierrez, C. Haupt, A. J. R. Heck, F. Herzog, L. Huang, M. R. Hoopmann, N. Kalisman, O. Klykov, Z. Kukacka, F. Liu, M. J. MacCoss, K. Mechtler, R. Mesika, R. L. Moritz, N. Nagaraj, V. Nesati, A. G. C. Neves-Ferreira, R. Ninnis, P. Novak, F. J. O'Reilly, M. Pelzing, E. Petrotchenko, L. Piersimoni, M. Plasencia, T. Pukala, K. D. Rand, J. Rappsilber, D. Reichmann, C. Sailer, C. P. Sarnowski, R. A. Scheltema, C. Schmidt, D. C. Schriemer, Y. Shi, J. M. Skehel, M. Slavin, F. Sobott, V. Solis-Mezarino, H. Stephanowitz, F. Stengel, C. E. Stieger, E. Trabjerg, M. Trnka, M. Vilaseca, R. Viner, Y. F. Xiang, S. Yilmaz, A. Zelter, D. Ziemianowicz, A. Leitner, A. Sinz, First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study. Anal Chem91, 6953-6961 (2019). https://doi.org/10.1021/acs.analchem.9b00658
Jaudzems, K., T. Polenova, G. Pintacuda, H. Oschkinat, A. Lesage, DNP NMR of biomolecular assemblies. J Struct Biol206, 90-98 (2019). https://doi.org/10.1016/j.jsb.2018.09.011
Jayapaul, J., L. Schröder, Nanoparticle-Based Contrast Agents for Xe-129 HyperCEST NMR and MRI Applications. Contrast Media Mol I2019, 9498173 (2019). Review, https://doi.org/10.1155/2019/9498173
Kampinga, H. H., C. Andreasson, A. Barducci, M. E. Cheetham, D. Cyr, C. Emanuelsson, P. Genevaux, J. E. Gestwicki, P. Goloubinoff, J. Huerta-Cepas, J. Kirstein, K. Liberek, M. P. Mayer, K. Nagata, N. B. Nillegoda, P. Pulido, C. Ramos, P. De los Rios, S. Rospert, R. Rosenzweig, C. Sahi, M. Taipale, B. Tomiczek, R. Ushioda, J. C. Young, R. Zimmermann, A. Zylicz, M. Zylicz, E. A. Craig, J. Marszalek, Function, evolution, and structure of J-domain proteins. Cell Stress Chaperon24, 7-15 (2019). Review, https://doi.org/10.1007/s12192-018-0948-4
Kasper, M. A., M. Glanz, A. Stengl, M. Penkert, S. Klenk, T. Sauer, D. Schumacher, J. Helma, E. Krause, M. C. Cardoso, H. Leonhardt, C. P. R. Hackenberger, Cysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations. Angew Chem Int Ed58, 11625-11630 (2019). https://doi.org/10.1002/anie.201814715
Kasper§, M. A., M. Glanz§, A. Oder, P. Schmieder, J. P. von Kries, C. P. R. Hackenberger, Vinylphosphonites for Staudinger-induced chemoselective peptide cyclization and functionalization. Chem Sci10, 6322-6329 (2019). https://doi.org/10.1039/c9sc01345h
Kasper, M. A., A. Stengl, P. Ochtrop, M. Gerlach, T. Stoschek, D. Schumacher, J. Helma, M. Penkert, E. Krause, H. Leonhardt*, C. P. R. Hackenberger*, Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates. Angew Chem Int Ed58, 11631-11636 (2019). https://doi.org/10.1002/anie.201904193
Kesten§, C., A. Wallmann§, R. Schneider, H. E. McFarlane, A. Diehl, G. A. Khan, B. J. van Rossum, E. R. Lampugnani, W. G. Szymanski, N. Cremer, P. Schmieder, K. L. Ford, F. Seiter, J. L. Heazlewood, C. Sanchez-Rodriguez, H. Oschkinat*, S. Persson*, The companion of cellulose synthase 1 confers salt tolerance through a Tau-like mechanism in plants. Nat Commun10, 857 (2019). https://doi.org/10.1038/s41467-019-08780-3
Klose, M., J. E. Salloum, H. Gonschior, S. Linder, SNX3 drives maturation of Borrelia phagosomes by forming a hub for PI(3)P, Rab5a, and galectin-9. J Cell Biol218, 3039-3059 (2019). https://doi.org/10.1083/jcb.201812106
König, B., Y. C. Hao, S. Schwartz, A. J. R. Plested, T. Stauber, A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength. Elife8, e45421 (2019). https://doi.org/10.7554/eLife.45421
Kreis*, P., C. Gallrein, E. Rojas-Puente, T. G. A. Mack, C. Kroon, V. Dinkel, C. Willmes, K. Murk, S. Tom-Dieck, E. M. Schuman, J. Kirstein*, B. J. Eickholt*, ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans. Nat Commun10, 486 (2019). https://doi.org/10.1038/s41467-019-08420-w
Le Roux, A. L., I. L. Mohammad, B. Mateos, M. Arbesu, M. Gairi, F. A. Khan, J. M. C. Teixeira, M. Pons, A Myristoyl-Binding Site in the SH3 Domain Modulates c-Src Membrane Anchoring. Iscience12, 194-203 (2019). https://doi.org/10.1016/j.isci.2019.01.010
Lehmann*, M., I. Lukonin, F. Noe, J. Schmoranzer, C. Clementi, D. Loerke, V. Haucke*, Nanoscale coupling of endocytic pit growth and stability. Sci Adv5, eaax5775 (2019). https://doi.org/10.1126/sciadv.aax5775
Li, X. L., S. W. Li, L. G. Yao, E. Mollo, M. Gavagnin, Y. W. Guo, The chemical and chemo-ecological studies on Weizhou nudibranch Glossodoris atromarginata. Magn Reson Chem, (2019). https://doi.org/10.1002/mrc.4949
Liu, C. P., C. Y. Xie, J. X. Zhao, K. L. Ji, X. X. Lei, H. Sun*, L. G. Lou*, J. M. Yue*, Dysoxylactam A: A Macrocyclolipopeptide Reverses P-Glycoprotein-Mediated Multidrug Resistance in Cancer Cells. J Am Chem Soc141, 6812-6816 (2019). Article https://doi.org/10.1021/jacs.9b02259
Lozza, L., P. Moura-Alves, T. Domaszewska, C. L. Crespo, I. Streata, A. Kreuchwig, A. Puyskens, M. Bechtle, M. Klemm, U. Zedler, B. S. Ungureanu, U. Guhlich-Bornhof, A. B. Koehler, M. Staber, H. J. Mollenkopf, R. Hurwitz, J. Furkert, G. Krause, J. Weiner, A. Jacinto, I. Mihai, M. Leite-de-Moraes, F. Siebenhaar, M. Maurer, S. H. E. Kaufmann, The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis. Sci Rep9, 10878 (2019). https://doi.org/10.1038/s41598-019-47350-x
Maglione, M., G. Kochlamazashvili, T. Eisenberg, B. Racz, E. Michael, D. Toppe, A. Stumpf, A. Wirth, A. Zeug, F. E. Müller, L. Moreno-Velasquez, R. P. Sammons, S. J. Hofer, F. Madeo, T. Maritzen, N. Maier, E. Ponimaskin, D. Schmitz, V. Haucke*, S. J. Sigrist*, Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses. Sci Rep9, 19616 (2019). https://doi.org/10.1038/s41598-019-56133-3
Marcinkowski, P., I. Hoyer, E. Specker, J. Furkert, C. Rutz, M. Neuenschwander, S. Sobottka, H. Sun, M. Nazaré, U. Berchner-Pfannschmidt, J. P. Von Kries, A. Eckstein, R. Schülein, G. Krause, A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy. Thyroid29, 111-123 (2019). Article https://doi.org/10.1089/thy.2018.0349
Marcinkowski, P., A. Kreuchwig, S. Mendieta, I. Hoyer, F. Witte, J. Furkert, C. Rutz, D. Lentz, G. Krause*, R. Schülein, Thyrotropin Receptor: Allosteric Modulators Illuminate Intramolecular Signaling Mechanisms at the Interface of Ecto- and Transmembrane Domain. Mol Pharmacol96, 452-462 (2019). https://doi.org/10.1124/mol.119.116947
Matthaeus, C., X. Lian, S. Kunz, M. Lehmann, C. Zhong, C. Bernert, I. Lahmann, D. N. Müller, M. Gollasch, O. Daumke, eNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization. PLoS One14, e0223620 (2019). https://doi.org/10.1371/journal.pone.0223620
Merkert, S., M. Schubert, R. Olmer, L. Engels, S. Radetzki, M. Veltman, B. J. Scholte, J. Zöllner, N. Pedemonte, L. J. V. Galietta, J. P. von Kries, U. Martin, High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs. Stem Cell Rep12, 1389-1403 (2019). https://doi.org/10.1016/j.stemcr.2019.04.014
Milito, A., M. Brancaccio, M. Lisurek, M. Masullo, A. Palumbo, I. Castellano, Probing the Interactions of Sulfur-Containing Histidine Compounds with Human Gamma-Glutamyl Transpeptidase. Mar Drugs17, E650 (2019). https://doi.org/10.3390/md17120650
Moura-Alves, P., A. Puyskens, A. Stinn, M. Klemm, U. Guhlich-Bornhof, A. Dorhoi, J. Furkert, A. Kreuchwig, J. Protze, L. Lozza, G. Pei, P. Saikali, C. Perdomo, H. J. Mollenkopf, R. Hurwitz, F. Kirschhoefer, G. Brenner-Weiss, J. Weiner, 3rd, H. Oschkinat, M. Kolbe, G. Krause, S. H. E. Kaufmann, Host monitoring of quorum sensing during Pseudomonas aeruginosa infection. Science366, eaaw1629 (2019). https://doi.org/10.1126/science.aaw1629
Müller, K. H., R. Hayward, R. Rajan, M. Whitehead, A. M. Cobb, S. Ahmad, M. X. Sun, I. Goldberga, R. Li, U. Bashtanova, A. M. Puszkarska, D. G. Reid, R. A. Brooks, J. N. Skepper, J. Bordoloi, W. Y. Chow, H. Oschkinat, A. Groombridge, O. A. Scherman, J. A. Harrison, A. Verhulst, P. C. D'Haese, E. Neven, L. M. Needham, S. F. Lee, C. M. Shanahan, M. J. Duer, Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization. Cell Rep27, 3124-3138 (2019). https://doi.org/10.1016/j.celrep.2019.05.038
Ni, C., P. Ma, R. R. Wang, X. H. Lou, X. M. Liu, Y. Qin, R. Xue, I. Blasig, U. Erben, Z. H. Qin, Doxorubicin-induced cardiotoxicity involves IFN gamma-mediated metabolic reprogramming in cardiomyocytes. J Pathol247, 320-332 (2019). https://doi.org/10.1002/path.5192
Nojoumi, S., Y. Ma, S. Schwagerus, C. P. R. Hackenberger, N. Budisa, In-Cell Synthesis of Bioorthogonal Alkene Tag S-Allyl-Homocysteine and Its Coupling with Reprogrammed Translation. Int J Mol Sci20, 2299 (2019). https://doi.org/10.3390/ijms20092299
Öster§, C., K. Hendriks§, W. Kopec, V. Chevelkov, C. W. Shi, D. Michl, S. Lange, H. Sun, B. L. de Groot, A. Lange, The conduction pathway of potassium channels is water free under physiological conditions. Sci Adv5, eaaw6756 (2019). https://doi.org/10.1126/sciadv.aaw6756
Pascolutti, R., V. Algisi, A. Conte, A. Raimondi, M. Pasham, S. Upadhyayula, R. Gaudin, T. Maritzen, E. Barbieri, G. Caldieri, C. Tordonato, S. Confalonieri, S. Freddi, M. G. Malabarba, E. Maspero, S. Polo, C. Tacchetti, V. Haucke, T. Kirchhausen, P. P. Di Fiore, S. Sigismund, Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling. Cell Rep27, 3049-3061 (2019). https://doi.org/10.1016/j.celrep.2019.05.017
Penkert*, M., A. Hauser, R. Harmel, D. Fiedler, C. P. R. Hackenberger, E. Krause*, Electron Transfer/Higher Energy Collisional Dissociation of Doubly Charged Peptide Ions: Identification of Labile Protein Phosphorylations. J Am Soc Mass Spectr30, 1578-1585 (2019). https://doi.org/10.1007/s13361-019-02240-4
Perez-Rius, C., M. Folgueira, X. Elorza-Vidal, A. Alia, M. B. Hoegg-Beiler, M. N. H. Eeza, M. L. Diaz, V. Nunes, A. Barrallo-Gimeno, R. Estevez, Comparison of zebrafish and mice knockouts for Megalencephalic Leukoencephalopathy proteins indicates that GlialCAM/MLC1 forms a functional unit. Orphanet J Rare Dis14, 268 (2019). https://doi.org/10.1186/s13023-019-1248-5
Plastira, I., L. Joshi, E. Bernhart, J. Schoene, E. Specker, M. Nazaré, W. Sattler, Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells. Front Cell Neurosci13, 531 (2019). https://doi.org/10.3389/fncel.2019.00531
Poulsen§, M. H., A. Poshtiban§, V. Klippenstein, V. Ghisi, A. J. R. Plested, Gating modules of the AMPA receptor pore domain revealed by unnatural amino acid mutagenesis. Proc Natl Acad Sci USA116, 13358-13367 (2019). https://doi.org/10.1073/pnas.1818845116
Puschmann§, R., R. K. Harmel§, D. Fiedler, Scalable Chemoenzymatic Synthesis of Inositol Pyrophosphates. Biochemistry58, 3927-3932 (2019). https://doi.org/10.1021/acs.biochem.9b00587
Sap, K. A., A. T. Guler, K. Bezstarosti, A. E. Bury, K. Juenemann, J. A. A. Demmers, E. A. Reits, Global Proteome and Ubiquitinome Changes in the Soluble and Insoluble Fractions of Q175 Huntington Mice Brains. Mol Cell Proteomics18, 1705-1720 (2019). https://doi.org/10.1074/mcp.RA119.001486
Schewe§*, M., H. Sun§, U. Mert, A. Mackenzie, A. C. W. Pike, F. Schulz, C. Constantin, K. S. Vowinkel, L. J. Conrad, A. K. Kiper, W. Gonzalez, M. Musinszki, M. Tegtmeier, D. C. Pryde, H. Belabed, M. Nazaré, B. L. de Groot, N. Decher, B. Fakler, E. P. Carpenter, S. J. Tucker, T. Baukrowitz, A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels. Science363, 875-880 (2019). https://doi.org/10.1126/science.aav0569
Schmidtke, C., S. Tiede, M. Thelen, R. Kakela, S. Jabs, G. Makrypidi, M. Sylvester, M. Schweizer, I. Braren, N. Brocke-Ahmadinejad, S. L. Cotman, A. Schulz, V. Gieselmann, T. Braulke, Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking. J Biol Chem294, 9592-9604 (2019). https://doi.org/10.1074/jbc.RA119.008852
Schneider, A. F. L., A. L. D. Wallabregue, L. Franz, C. P. R. Hackenberger, Targeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptides. Bioconjugate Chem30, 400-404 (2019). https://doi.org/10.1021/acs.bioconjchem.8b00855
Schnurr, M., R. Joseph, A. Naugolny-Keisar, D. Kaizerman-Kane, N. Bogdanoff, P. Schuenke, Y. Cohen*, L. Schröder*, High Exchange Rate Complexes of Xe-129 with Water-Soluble Pillar[5]arenes for Adjustable Magnetization Transfer MRI. ChemPhysChem20, 246-251 (2019). https://doi.org/10.1002/cphc.201800618
Schoene, J., T. Gazzi, P. Lindemann, M. Christmann, A. Volkamer*, M. Nazaré*, Probing 2H-Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors. ChemMedChem14, 1514-1527 (2019). https://doi.org/10.1002/cmdc.201900328
Schumacher, D., H. Leonhardt, C. P. R. Hackenberger, J. Helma, One-Step Fluorescent Protein Labeling by Tubulin Tyrosine Ligase. Methods Mol Biol2033, 167-189 (2019). Book Chapter, https://doi.org/10.1007/978-1-4939-9654-4_12
Shi§*, C. W., C. Öster§, C. Bohg, L. M. Li, S. Lange, V. Chevelkov, A. Lange*, Structure and Dynamics of the Rhomboid Protease GlpG in Liposomes Studied by Solid-State NMR. J Am Chem Soc141, 17314-17321 (2019). https://doi.org/10.1021/jacs.9b08952
Sladojevic, N., S. M. Stamatovic, A. M. Johnson, J. Choi, A. N. Hu, S. Dithmer, I. E. Blasig, R. F. Keep, A. V. Andjelkovic, Claudin-1-Dependent Destabilization of the Blood-Brain Barrier in Chronic Stroke. J Neurosci39, 743-757 (2019). https://doi.org/10.1523/Jneurosci.1432-18.2018
Smith, D., A. G. Buddie, R. J. M. Goss, J. Overmann, C. Lepleux, M. Bronstrup, B. Kloaregs, T. Meiners, P. Brennecke, A. Ianora, F. Y. Bouget, P. Gribbon, M. Pina, Discovery pipelines for marine resources: an ocean of opportunity for biotechnology? World J Microb Biot35, 107 (2019). Review, https://doi.org/10.1007/s11274-019-2685-y
Song, K., C. Gras, G. Capin, N. Gimber, M. Lehmann, S. Mohd, D. Puchkov, M. Rödiger, I. Wilhelmi, O. Daumke, J. Schmoranzer, A. Schürmann, M. Krauss, A SEPT1-based scaffold is required for Golgi integrity and function. J Cell Sci132, jcs225557 (2019). https://doi.org/10.1242/jcs.225557
Stengl, A., M. Gerlach, M. A. Kasper, C. P. R. Hackenberger, H. Leonhardt, D. Schumacher, J. Helma, TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles. Org Biomol Chem17, 4964-4969 (2019). https://doi.org/10.1039/c9ob00508k
Tiosano, D., H. N. Baris, A. Chen, M. M. Hitzert, M. Schueler, F. Gulluni, A. Wiesener, A. Bergua, A. Mory, B. Copeland, J. G. Gleeson, P. Rump, H. van Meer, D. A. Sival, V. Haucke, J. Kriwinsky, K. X. Knaup, A. Reis, N. N. Hauer, E. Hirsch, R. Roepman, R. Pfundt, C. T. Thiel, M. S. Wiesener, M. G. Aslanyan, D. A. Buchner, Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction. PLoS Genet15, e1008088 (2019). https://doi.org/10.1371/journal.pgen.1008088
Ullrich, F., S. Blin, K. Lazarow, T. Daubitz, J. P. von Kries, T. J. Jentsch, Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels. Elife8, e49187 (2019). https://doi.org/10.7554/eLife.49187
van Drogen, F., R. Mishra, F. Rudolf, M. J. Walczak, S. S. Lee, W. Reiter, B. Hegemann, S. Pelet, I. Dohnal, A. Binolfi, Z. Yudina, P. Selenko, G. Wider, G. Ammerer, M. Peter, Mechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5. J Cell Biol218, 3117-3133 (2019). https://doi.org/10.1083/jcb.201808161
van Husen, L. S., S. Schedin-Weiss, M. Nguyen Trung, M. A. Kazmi, B. Winblad, T. P. Sakmar, S. J. Elsässer, L. O. Tjernberg, Dual Bioorthogonal Labeling of the Amyloid-beta Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products. J Alzheimers Dis72, 537-548 (2019). https://doi.org/10.3233/Jad-190898
Visweshwaran, S. P., T. Maritzen, A simple 3D cellular chemotaxis assay and analysis workflow suitable for a wide range of migrating cells. Methodsx6, 2807-2821 (2019). https://doi.org/10.1016/j.mex.2019.11.001
Vukicevic, T., C. Hinze, S. Baltzer, N. Himmerkus, C. Quintanova, K. Zühlke, F. Compton, R. Ahlborn, A. Dema, J. Eichhorst, B. Wiesner, M. Bleich, K. M. Schmidt-Ott, E. Klussmann, Fluconazole Increases Osmotic Water Transport in Renal Collecting Duct through Effects on Aquaporin-2 Trafficking. J Am Soc Nephrol30, 795-810 (2019). https://doi.org/10.1681/Asn.2018060668
Wallroth, A., P. A. Koch, A. L. Marat, E. Krause, V. Haucke, Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1. Nat Cell Biol21, 1093-1101 (2019). https://doi.org/10.1038/s41556-019-0377-3
Wang, H. B., W. T. Lo, V. Haucke, Phosphoinositide switches in endocytosis and in the endolysosomal system. Curr Opin Cell Biol59, 50-57 (2019). Review, https://doi.org/10.1016/j.ceb.2019.03.011
Wong, E. L., E. Nawrotzky, C. Arkona, B. G. Kim, S. Beligny, X. N. Wang, S. Wagner, M. Lisurek, D. Carstanjen, J. Rademann*, The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation. Nat Commun10, 66 (2019). https://doi.org/10.1038/s41467-018-07923-2
Wortmann, L., B. Lindenthal, P. Muhn, A. Walter, R. Nubbemeyer, D. Heldmann, L. Sobek, F. Morandi, A. K. Schrey, D. Moosmayer, J. Günther, J. Kuhnke, M. Koppitz, U. Lucking, U. Rohn, M. Schäfer, K. Nowak-Reppel, R. Kühne, H. Weinmann, G. Langer, Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo. J Med Chem62, 10321-10341 (2019). https://doi.org/10.1021/acs.jmedchem.9b01382
Wrackmeyer, U., J. Kaldrack, R. Jüttner, U. Pannasch, N. Gimber, F. Freiberg, B. Purfürst, D. Kainmueller, D. Schmitz, V. Haucke, F. G. Rathjen, M. Gotthardt, The cell adhesion protein CAR is a negative regulator of synaptic transmission. Sci Rep9, 6768 (2019). https://doi.org/10.1038/s41598-019-43150-5
Wu, Q. H., F. Ye, X. L. Li, L. F. Liang, J. D. Sun, H. Sun, Y. W. Guo, H. Wang, Uncommon Polyoxygenated Sesquiterpenoids from South China Sea Soft Coral Lemnalia flava. J Org Chem84, 3083-3092 (2019). https://doi.org/10.1021/acs.joc.8b02912
Yang§, M., X. L. Li§, J. R. Wang, X. X. Lei, W. Tang, X. W. Li*, H. Sun*, Y. W. Guo*, Sarcomililate A, an Unusual Diterpenoid with Tricyclo[11.3.0.0(2,16)]hexadecane Carbon Skeleton, and Its Potential Biogenetic Precursors from the Hainan Soft Coral Sarcophyton mililatensis. J Org Chem84, 2568-2576 (2019). https://doi.org/10.1021/acs.joc.8b03020
Zhang, Q. Y., S. N. Xu, F. F. Lai, Y. L. Wang, N. Zhang, M. Nazaré, H. Y. Hu, Rapid Synthesis of gamma-Halide/Pseudohalide-Substituted Cyanine Sensors with Programmed Generation of Singlet Oxygen. Org Lett21, 2121-2125 (2019). https://doi.org/10.1021/acs.orglett.9b00404
Zhao, X. L., K. Zhang, P. Daniel, N. Wisbrun, H. Fuchs, F. H., Delayed allogeneic skin graft rejection in CD26-deficient mice. Cellular and Molecular Immunology16, 557-567 (2019). https://doi.org/10.1038/s41423-018-0009-z
Zhu, J., K. Lau, R. Puschmann, R. K. Harmel, Y. J. Zhang, V. Pries, P. Gaugler, L. Broger, A. K. Dutta, H. J. Jessen, G. Schaaf, A. R. Fernie, L. A. Hothorn, D. Fiedler, M. Hothorn, Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis. Elife8, e43582 (2019). https://doi.org/10.7554/eLife.43582