Protein Trafficking (Ralf Schülein)

Publications

2017

Gibert, A., M. Lehmann, B. Wiesner and R. Schülein (2017). The Monomer/Homodimer Equilibrium of G Protein-Coupled Receptors: Formation in the Secretory Pathway and Potential Functional Significance. G-Protein-Coupled Receptor Dimers. K. Herrick-Davis, G. Milligan and G. Di Giovanni. Cham, Springer International Publishing: 359-384.

Blex, C., S. Michaelis, A. K. Schrey, J. Furkert, J. Eichhorst, K. Bartho, F. G. Quast, A. Marais, M. Hakelberg, U. Gruber, S. Niquet, O. Popp, F. Kroll, M. Sefkow, R. Schülein, M. Dreger and H. Köster (2017). "Targeting G-protein-coupled receptors by Capture Compound Mass Spectrometry (CCMS) - a case study with sertindole." Chembiochem. 18:1639-1649.

Hinz, K. M., D. Neef, C. Rutz, J. Furkert, J. Kohrle, R. Schulein and G. Krause (2017). "Molecular features of the L-type amino acid transporter 2 determine different import and export profiles for thyroid hormones and amino acids." Mol Cell Endocrinol 443: 163-174.

Leonhardt, J., D. C. Villela, A. Teichmann, L. M. Munter, M. C. Mayer, M. Mardahl, S. Kirsch, P. Namsolleck, K. Lucht, V. Benz, N. Alenina, N. Daniell, M. Horiuchi, M. Iwai, G. Multhaup, R. Schulein, M. Bader, R. A. Santos, T. Unger and U. M. Steckelings (2017). "Evidence for Heterodimerization and Functional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS." Hypertension 69(6): 1128-1135.

Schulein, R., A. Gibert and C. Rutz (2017). "Functional Significance of the Signal Peptides of Corticotropin-Releasing Factor Receptors." Curr Mol Pharmacol.

2015

Hinz, K. M., K. Meyer, A. Kinne, R. Schulein, J. Kohrle and G. Krause (2015). "Structural insights into thyroid hormone transport mechanisms of the L-type amino acid transporter 2." Mol Endocrinol 29(6): 933-942.

 

Kinne, A., M. Wittner, E. K. Wirth, K. M. Hinz, R. Schulein, J. Kohrle and G. Krause (2015). "Involvement of the L-Type Amino Acid Transporter Lat2 in the Transport of 3,3'-Diiodothyronine across the Plasma Membrane." Eur Thyroid J 4(Suppl 1): 42-50.

 

Klein, W., C. Westendorf, A. Schmidt, M. Conill-Cortes, C. Rutz, M. Blohs, M. Beyermann, J. Protze, G. Krause, E. Krause and R. Schulein (2015). "Defining a conformational consensus motif in cotransin-sensitive signal sequences: a proteomic and site-directed mutagenesis study." PLoS One 10(3): e0120886.

 

Rutz, C., W. Klein and R. Schulein (2015). "N-Terminal Signal Peptides of G Protein-Coupled Receptors: Significance for Receptor Biosynthesis, Trafficking, and Signal Transduction." Prog Mol Biol Transl Sci 132: 267-287.

 

Vezzoli, V., P. Duminuco, A. Vottero, G. Kleinau, R. Schulein, R. Minari, I. Bassi, S. Bernasconi, L. Persani and M. Bonomi (2015). "A new variant in signal peptide of the human luteinizing hormone receptor (LHCGR) affects receptor biogenesis causing leydig cell hypoplasia." Hum Mol Genet 24(21): 6003-6012.

2014

Grzesik, P., A. Teichmann, J. Furkert, C. Rutz, B. Wiesner, G. Kleinau, R. Schulein, J. Gromoll and G. Krause (2014). "Differences between lutropin-mediated and choriogonadotropin-mediated receptor activation." Febs j 281(5): 1479-1492.

 

Schmidt, A., B. Wiesner, R. Schulein and A. Teichmann (2014). "Use of Kaede and Kikume green-red fusions for live cell imaging of G protein-coupled receptors." Methods Mol Biol 1174: 139-156.

 

Teichmann, A., A. Gibert, A. Lampe, P. Grzesik, C. Rutz, J. Furkert, J. Schmoranzer, G. Krause, B. Wiesner and R. Schulein (2014). "The specific monomer/dimer equilibrium of the corticotropin-releasing factor receptor type 1 is established in the endoplasmic reticulum." J Biol Chem 289(35): 24250-24262.

2013

Schmidt A, Wiesner B, Schülein R, Teichmann A (2013) Use of Kaede and Kikume green-red fusions for live cell imaging of G protein-coupled receptors. Methods Mol Biol. In press

Hoyer I, Haas AK, Kreuchwig A, Schülein R, Krause G.  (2013) Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonists. Biochem Soc Trans. 2013 Feb 1;41(1):213-7

2012

Teichmann A, Schmidt A, Wiesner B, Oksche A, Schülein R. (2012) Live cell imaging of G protein-coupled receptors. Methods Mol Biol. 2012;897:139-69

Teichmann A, Rutz C, Kreuchwig A, Krause G, Wiesner B, Schülein R. (2012) The Pseudo signal peptide of the corticotropin-releasing factor receptor type 2A prevents receptor oligomerization. J Biol Chem. 3;287(32):27265-74

Zampatis DE, Rutz C, Furkert J, Schmidt A, Wüstenhagen D, Kubick S, Tsopanoglou NE, Schülein R. (2012) The protease-activated receptor 1 possesses a functional and cleavable signal peptide which is necessary for receptor expression. FEBS Lett. 30;586(16):2351-9

Ridelis I, Schmidt A, Teichmann A, Furkert J, Wiesner B, Schülein R. (2012) Use of Kikume green-red fusions to study the influence of pharmacological chaperones on trafficking of G protein-coupled receptors. FEBS Lett. 23;586(6):784-91

Liu Y, Echtermeyer F, Thilo F, Theilmeier G, Schmidt A, Schülein R, Jensen BL, Loddenkemper C, Jankowski V, Marcussen N, Gollasch M, Arendshorst WJ, Tepel M. (2012) The proteoglycan syndecan 4 regulates transient receptor potential canonical 6 channels via RhoA/Rho-associated protein kinase signaling. Arterioscler Thromb Vasc Biol. 32(2):378-85

Schülein, R., Westendorf, C. Krause, G., and Rosenthal W. (2012) Functional significance of cleavable signal peptides of G protein-coupled receptors. Eur. J. Cell Biol. 91, 294-299

Ridelis, I., Schmidt, A., Teichmann, A., Furkert, J., Wiesner, B., and Schülein, R. (2012) Use of Kikume Green-Red Fusions to study the influence of pharmacological chaperones on trafficking of G protein-coupled receptors. FEBS Lett. 586, 784-791

2011

Kinne A, Schülein R, Krause G. (2011) Primary and secondary thyroid hormone transporters. Thyroid Res. 3;4 Suppl 1:S7

Westendorf C, Schmidt A, Coin I, Furkert J, Ridelis I, Zampatis D, Rutz C, Wiesner B, Rosenthal W, Beyermann M, Schülein R. (2011) Inhibition of biosynthesis of human endothelin B receptor by the cyclodepsipeptide cotransin. J Biol Chem. 14;286(41):35588-600

Kleinau G, Hoyer I, Kreuchwig A, Haas AK, Rutz C, Furkert J, Worth CL, Krause G, Schülein R. (2011) From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs). J Biol Chem. 22;286(29):25859-71

Westendorf, C., Schmidt, A., Coin, I., Furkert, J., Ridelis, I., Zampatis, D., Rutz, C., Wiesner, B., Rosenthal, W., Beyermann, M., and Schülein, R. (2011) Inhibition of biosynthesis of human endothelin B receptor by the cyclodepsipeptide cotransin. J. Biol. Chem. 286, 35588-355600

Haas AK, Kleinau G, Hoyer I, Neumann S, Furkert J, Rutz C, Schülein R, Gershengorn MC, Krause G. (2011) Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor. Cell Mol Life Sci. 68(1):159-67

2010

Schulz, K., Rutz, C., Westendorf, C., Ridelis, I., Vogelbein, S., Furkert, J., Schmidt, A., Wiesner, B., and Schülein, R. (2010) The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity. J. Biol. Chem. 285, 32878-32887

Kleinau, G., Haas, A.K., Neumann, S., Worth, C.L., Hoyer, I., Furkert, J., Rutz, C., Gershengorn, M.C., Schülein, R., and Krause, G. (2010) Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor. FASEB J. 24, 2347-2354

2009

Alken, M., Schmidt, A., Rutz, C., Furkert, J., Kleinau, G., Rosenthal, W., and Schülein, R. (2009) The sequence after the signal peptide of the G protein-coupled endothelin B receptor is required for efficient translocon gating at the endoplasmic reticulum membrane. Mol. Pharmacol. 75, 801-811

Schmidt, A., Wiesner, B., Weißhart, K., Schulz, K., Furkert, J., Lamprecht, B., Rosenthal, W., and Schülein, R. (2009) Use of Kaede fusions to visualize recycling of G protein-coupled receptors. Traffic 10, 2-15

2007

Oueslati, M., Hermosilla, R., Schönenberger, E., Oorschot, V., Beyermann, M., Wiesner, B., Schmidt, A., Klumperman, J., Rosenthal, W., and Schülein, R. (2007) Rescue of a nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutant by cell-penetrating peptides. J. Biol. Chem. 282, 20676-20685.

2006

Rutz, C., Renner, A., Alken, M., Schulz, K., Beyermann, M., Wiesner, B., Rosenthal, W., and Schülein, R. (2006) The corticotropin-releasing factor receptor type 2a contains an N-terminal pseudo signal peptide. J. Biol. Chem. 281, 24910-24921.

Bulwin, G.C, Heinemann, T., Bugge, V., Winter, M., Lohan, A., Schlawinsky, M., Schulze, A., Walter, S., Sabat, R., Schülein, R., Wiesner, B., Veh, R.W., Lohler, J., Blumberg, R.S., Volk, H.D., and Utku N. (2006) TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression. J. Immunol. 177, 6833-6841.

2005

Thielen, A., Oueslati, M., Hermosilla, R., Krause, G., Oksche, A., Rosenthal, W. and Schülein, R. (2005) The hydrophobic amino acid residues in the membrane-proximal C tail of the G protein-coupled vasopressin V2 receptor are necessary for transport-competent receptor folding. FEBS Lett. 579, 5227-5235.

Neuschäfer-Rube, F., Hermosilla, R., Kuna, M., Pathe-Neuschäfer-Rube, A., Schülein, R., and Püschel, G.P. (2005) A Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalization. Br. J. Pharmacol. 145, 1132-1142.

Alken, M., Rutz, C., Köchl, R., Donalies, U., Oueslati, M., Furkert, J., Wietfeld, D., Hermosilla, R., Scholz, A., Beyermann, M., Rosenthal, W., and Schülein R. (2005) The signal peptide of the rat corticotropin-releasing factor receptor 1 promotes receptor expression but is not essential for establishing a functional receptor. Biochem J. 390, 455-464.

Cai, G., Salonikidis, P.S., Fei, J., Schwarz, W., Schülein, R., Reutter, W., and Fan, H. (2005) The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1. Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter. FEBS J. 272, 1625-38.

2004

Hermosilla, R., Oueslati, M., Donalies, U., Schönenberger, E., Krause, E., Oksche, A., Rosenthal, W., and Schülein R. (2004) Disease-causing V2 vasopressin receptors are retained in different compartments of the early secretory pathway. Traffic 5, 993-1005.

Wüller, S., Wiesner, B., Löffler, A., Furkert, J., Krause, G., Hermosilla, R., Schaefer, M., Schülein, R., Rosenthal, W., Oksche, A. (2004) Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors. J. Biol. Chem. 279, 47254-63.

Droese, J., Mokros, T., Hermosilla, R., Schülein, R., Dörken, B., Lipp, M., Höpken, U., and Rehm, A. (2004) The HCMV chemokine receptor homologue US28 employs multiple routes for internalization. Biochem. Biophys. Res. Commun. 322, 42-49.

Neuschäfer-Rube, F., Rehwald, M., Hermosilla, R., Schülein, R., Rönnstrand, L., and Püschel, G. (2004) Requirement of different Ser/Thr residues in the C-terminal domain of the human EP4 receptor for agonist-induced phosphorylation, Beta arrestin interaction and sequestration. Biochem. J. 379, 573-585.

Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
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info(at)fmp-berlin.de

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