Proteostasis in Aging and Disease (Janine Kirstein)
Publications
2020
Pigazzini ML & Kirstein J
In vivo quantification of protein turnover in aging C. elegans using the photoconvertable Dendra2
J. Vis Exp., in press
Iburg M, Puchkov D, Brugada IUR, Bergemann L, Rieprecht U & Kirstein J
The non-canonical small heat shock protein HSP-17 from C. elegans is a selective protein aggregase
J Biol Chem, Jan 30 doi: 10.1074/jbc.RA119.011185.
Pigazzini ML, Gallrein C, Iburg M, Kaminski Schierle G, Kirstein J
Characterisation of amyloid structures in aging C. elegans using fluorescence lifetime imaging.
J. Vis Exp., in press
2019
Sandhof CA, Hoppe SO, Druffel-Augustin S, Gallrein C, Kirstein J, Voisine C, Nussbaum-Krammer C
Reducing INS-IGF1 Signaling Protects Against Non-Cell Autonomous Vesicle Rupture Caused by SNCA Spreading
Autophagy, 2019 Jul 29:1-22.
Feleciano DR, Juenemann K, Iburg M, Bras I, Holmberg CI, Kirstein J
Crosstalk between chaperone-mediated protein disaggregation and proteolytic pathways in aging and disease”
Frontiers in Aging Neuroscience, 2019 Jan 29;11:9
Kreis P*#, Gallrein C#, Rojas-Puente E#, Mack TGA, Kroon C, Dinkel V, Willmes C, Murk K, tom-Dieck S, Schuman EM, Kirstein J*, Eickholt BJ*
ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans
Nature Communications, 019 Jan 30;10(1):486 (# co-first authors; * co-corresponding authors)
2018
Kampinga HH, Andreasson C, Barducci A, Cheetham ME, Cyr D, Emanuelsson C, Genevaux P, Gestwicki JP, Goloubinoff P, Huerta-Cepas J, Kirstein J, Liberek K, Mayer MP, Nagata K, Nillegoda NB, Pulido P, Ramos C, De los Rios P, Rospert S, Rosenzweig R, Sahi C, Taipale M, Tomiczek B, Ushioda R, Young JC, Zimmermann R, Zylicz A, Zylicz M, Craig EA, Marszalek J
Function, evolution, and structure of J-domain proteins
Cell Stress and Chaperones, 2018 Nov 26. doi: 10.1007/s12192-018-0948-4
Ast A, Buntru A, Schindler F, Hasenkopf R, Schulz A, Brusendorf L, Klockmeier K, Grelle G, McMahon B, Niederlechner H, Jansen I, Diez LM, Boeddrich A, Franklin SA, Baldo B, Schnoegl S, Kunz S, Purfürst B, Kampinga HH, Morton AJ, Petersén A, Kirstein J, Bates GP, Wanker EE
Mutant HTT seeding activity: a marker of disease progression and neurotoxicity in models of Huntington’s disease.
Molecular Cell, 2018; 71(5):675-688
Juenemann K, Jansen AHP, van Riel L, Merkx R, Mulder MPC, An H, Statsyuk A, Kirstein J, Ovaa H, Reits EA
Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies
Scientific Reports, 2018 23;8(1):1405
Scior A, Buntru A, Arnsburg K, Ast A, Iburg M, Juenemann K, Pigazzini ML, Mlody B, Puchkov D, Priller J, Wanker EE, Prigione A, Kirstein J
Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a chaperone complex.
The EMBO Journal, 2018; 37(2)282-299
2017
Kirstein J, Arnsburg K, Scior A, Szlachcic A, Guilbride DL, Morimoto RI, Bukau B & Nillegoda NB
In vivo properties of the disaggregase function of J-proteins and Hsc70 in C. elegans stress and aging
Aging Cell, 2017 Oct 10. doi: 10.1111/acel.12686.
Lechler MC, Crawford ED, Groh N, Widmaier K, Jung R, Kirstein J, Trinidad JC, Burlingame AL, David DC
Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging
Cell Reports, 2017
2016
Feleciano RD, Arnsburg K & Kirstein J
Interplay between redox and protein homeostasis
Worm, 2016
Scior A, Juenemann K & Kirstein J
Cellular strategies to cope with protein aggregation
Essays in Biochemistry, 2016
2015
Feleciano RD & Kirstein J
Collapse of redox homeostasis during aging and stress
Molecular & Cellular Oncology, 2015
Nillegoda N, Kirstein J, Szlachcic A, Berynskyy M, Stank A, Stengel F, Arnsburg K, Gao X, Scior A, Aebersold R, Guilbride DL, Wade RC, Morimoto RI, Mayer MP and Bukau B
Crucial Hsp70 co-chaperone complex unlocks metazoan protein disaggregation
Nature, 2015
Kirstein J*, Morito D, Kakihana T, Sugihara M, Minnen A, Hipp MS, Nussbaum-Krammer C, Hartl FU*, Nagata K* & Morimoto RI*
Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments
EMBO J, 2015 (* corresponding authors)
2014
Arnsburg, K & Kirstein-Miles, J
Interrelation between Protein Synthesis, Proteostasis and Life Span
Current Genomics, 2014
Kirstein-Miles J, Morimoto RI
Protein Homeostasis in Health and Aging
Molecular and Cellular Biology of Aging
Bartlett and Jones Publishers, 2014
2013
Kirstein-Miles J, Morimoto RI
Ribosome-associated chaperones act as proteostasis sentinels.
Cell Cycle, 2013
Kirstein-Miles J*, Scior A*, Deuerling E, Morimoto RI
The nascent polypeptide associated complex is a key regulator of proteostasis.
EMBO J, 2013; (* equal contribution)
2012
Rampelt H, Kirstein-Miles J, Nillegoda NB, Kang C, Scholz SR, Morimoto RI, Bukau B
Metazoan Hsp70 machines use Hsp110 to power protein disaggregation.
EMBO J, 2012
Lowth BR, Kirstein-Miles J, Broetz-Oesterhelt H, Morimoto RI, Truscott KN, Dougan DA
Identification and characterization of hClpX-interacting proteins, using a hClpXP Walker B mutant.
J Struct. Biol, 2012
2010
Wolf D, Kalamorz F, Wecke T, Juszczak A, Mäder U, Homuth G, Jordan S, Kirstein J, Hoppert M, Voigt B, Hecker M, Mascher T.
In-depth profiling of the LiaR response of Bacillus subtilis.
J Bacteriol, 2010
Kirstein-Miles J, Morimoto RI
Peptides signal mitochondrial stress.
Cell Metab, 2010
Kirstein-Miles J, Morimoto RI
Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases.
Dev Dyn, 2010
2009
Kirstein J, Moliere N, Dougan DA, Turgay K
Adapting the machine: Adaptor proteins for Hsp100/Clp and AAA+ proteases
Nat Rev Microbiol, 2009
Kirstein J, Hoffmann A, Lilie H, Schmidt R, Ruebsamen-Waigmann H, Broetz-Oesterhelt H, Mogk A, Turgay K
The antibiotic ADEP reprograms ClpP, switching it from a regulated to an uncontrolled protease.
EMBO Mol Med, 2009
2008
Kirstein J, Strahl H, Moliere N, Hamoen, L & Turgay K
Localization of general and regulatory proteolysis in Bacillus subtilis cells.
Mol Microbiol, 2008
Haslberger T, Zdanowicz A, Brand I, Kirstein J, Turgay K, Mogk A, Bukau B
Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments.
Nat Struct Mol Biol, 2008
Erbse AH, Wagner JN, Truscott KN, Spall SK, Kirstein J, Zeth K, Turgay K, Mogk A, Bukau B, Dougan DA
Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding
FEBS J, 2008
2007
Kirstein J, Dougan DA, Gerth U, Hecker M & Turgay K
The tyrosine kinase McsB is a regulated adaptor protein for ClpCP
EMBO J, 2007
2006
Kirstein J, Schlothauer T, Dougan DA, Lilie H, Tischendorf G, Mogk A, Bukau B, Turgay K.
Adaptor protein controlled oligomerization activates the AAA+ protein ClpC.
EMBO J, 2006
Andersson FI, Blakytny R, Kirstein J, Turgay K, Bukau B, Mogk A, Clarke AK.
Cyanobacterial ClpC/HSP100 protein displays intrinsic chaperone activity.
J Biol Chem, 2006
2005
Kirstein J, Zuhlke D, Gerth U, Turgay K, Hecker M.
A tyrosine kinase and its activator control the activity of the CtsR heat shock repressor in B. subtilis.
EMBO J, 2005
Kirstein J, Turgay K.
A new tyrosine phosphorylation mechanism involved in signal transduction in Bacillus subtilis.
J Mol Microbiol Biotechnol, 2005
2004
Gerth U, Kirstein J, Mostertz J, Waldminghaus T, Miethke M, Kock H, Hecker M.
Fine-tuning in regulation of Clp protein content in Bacillus subtilis.
J Bacteriol, 2004
2003
Rollenhagen C, Antelmann H, Kirstein J, Delumeau O, Hecker M, Yudkin MD.
Binding of sigma(A) and sigma(B) to core RNA polymerase after environmental stress in Bacillus subtilis.
J Bacteriol, 2003
