Contact

Dr. Michael Beyermann

phone +49 30 94793 272
fax +49 30 94793 159
beyermann(at)fmp-berlin.de

Former Research Group of FMP: Peptide Synthesis (Michael Beyermann)

Our group is interested in acquiring insight into the molecular basis of interaction between peptide ligands and their membrane-embedded receptors, in particular G protein-coupled receptors class B. These receptors are functional only when embedded in membrane, wherefore it is difficult to obtain direct structural information by spectroscopic methods such as X-ray crystallography or NMR methods. Indirect methods such as structure-activity relationship studies (A), modifying the ligand or receptor by point substitutions, may give a rough idea of requirements for their interaction, but the results are often afflicted with the dilemma of an ambiguous interpretation. Investigation of individual receptor domains may be of interest, if they show ligand binding behaviors which are close to that of the entire receptor. In this case the structural analysis of such soluble receptor domain-ligand complexes might provide a first idea of the structural arrangement of ligand and receptor. We are investigating, therefore, ligand binding to extracellular domains (EC1-4) of CRF receptors, showing a crucial contribution of these domains to receptor affinity for ligands (B). Such studies require development of efficient chemical and biotechnological methods for preparation of individual receptor domains which will be assembled to constructs of EC1-4 that will be investigated with respect to ligand binding (C).

A
A
B
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C

Moreover, since peptides are valuable tools for biomedical studies, our group collaborates with several research groups inside and outside the institute.

Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)
info(at)fmp-berlin.de

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