Chemical Biology II (Christian Hackenberger)

Research Overview

In the densely packed world of a cell, many signaling pathways that support healthy functioning and are disrupted in disease are controlled by the modification of proteins. The most common of these functionalization events are phosphorylation and glycosylation, but increasingly other so-called post-translational modifications such as acetylation and methylation are being identified as important "toggle switches" in health and disease. Chemical biologists increasingly want to selectively control functionalization of proteins in the cell both to study the biological role of post-translational modifications and to decorate proteins with fluorescent moieties that permit their visualization, or molecular tags that allow a straightforward purification.

The Hackenberger laboratory constantly aims to identify new bioconjugation strategies that allow the functionalization of peptides and proteins, both on isolated biomolecules as well as in living cells and organisms. In this, our main focus is to apply these highly selective organic reactions together with other established chemoselective or biorthogonal reactions and biochemical methods to study functional consequences of natural protein modifications as well as to generate novel peptide- and protein-conjugates for pharmaceutical and medicinal applications (Figure 1).

Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)
info(at)fmp-berlin.de

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