Junior Research Group: ChemBioProbes (Johannes Broichhagen)

Publications

33.Transformation of Receptor Tyrosine Kinases into Glutamate Receptors and Photoreceptors, Leippe, P.#; Broichhagen, J.#; Cailliau, K.; Mougel, A.; Morel, M.; Dissous, C.; Trauner, D.; Vicogne, J., Angew. Chem. Int. Ed. 2020, in press.

32.Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics, Ast, J.; Arvaniti, A.; Fine N. H. F.; Nasteska, D.; Ashford, F.; Stamataki, Z.; Koszegi, Z.; Bacon, A.; Jones, B. J.; Lucey, M. A.; Sasaki, S.; Hastoy, B.; Tomas, A.; Reiman, F.; D’Agostino, G.; Reiman, F.; Lynn, F. C.; Reissaus, C.; Linnemann, A. K.; D’Este, E.; Calebiro, D.; Trapp, S.; Johnsson, K.; Podewin, T.*; Broichhagen, J.*; Hodson, D. J.*, Nat. Commun. 2020, 11, 467.

31. Branched photoswitchable tethered ligands enable ultra-efficient optical control and detection of G protein-coupled receptors in vivo, Acosta-Ruiz, A.; Gutzeit, V. A.; Skelly, M. J.; Meadows, S.; Lee, J.; Parekh, P.; Orr, A. G.; Liston, C.; Pleil, K. E.; Broichhagen, J.*; Levitz, J.*, Neuron 2020, 105, 446–463.

30.Genetically-targeted optical control of an endogenous G protein-coupled receptor, Donthamsetti, P. C.; Broichhagen, J.; Vyklicky, V.; Stanley, C.; Fhu, Z.; Visel, M.; Levitz, J.; Javitch, J. A.; Trauner, D.; Isacoff, E. Y. J. Am. Chem. Soc. 2019, 141, 11522–11530.

29.CCDC 1884029: Experimental Crystal Structure Determination, Broichhagen, J.; Burg, F.; Häfner, S.; Mayer, P.; Trauner, D., CSD Communication 2018, https;//doi.org/10.5517/ccdc.csd.cc217h4y.

28.Optical tools for understanding the complexity of beta cell signaling and insulin release, Frank, J. A.#, Broichhagen, J.#; Yushchenko, D.; Schultz, C.; Trauner, D.; Hodson, D. J., Nat. Rev. Endocrinol. 2018, 14, 721–737.

27.SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand, Farrants, H.; Acosta Ruiz, A.; Gutzeit, V. A.; Trauner, D.; Johnsson, K.; Levitz, J.*; Broichhagen, J.*, ACS Chem. Bio. 2018, 13, 2682–2688.

26.A New Fluorogenic Small-Molecule Labeling Tool for Surface Diffusion Analysis and Advanced Fluorescence Imaging of β-site Amyloid Precursor Protein-Cleaving Enzyme 1 Based on Silicone Rhodamine: SiR-BACE1, Karch, S.#, Broichhagen, J.#; Schneider, J.#; Böning, D.; Hartmann, S.; Schmid, B.; Tripal, P.; Palmisano, R.; Alzheimer, C.; Johnsson, K.; Huth, T., J. Med. Chem. 2018, 61, 6121–6139.

25.A (+)-larixol congener with high affinity and subtype selectivity towards TRPC6, Häfner, S.; Burg, F.; Kannler, M.; Urban, N.; Mayer, P.; Dietrich, A.; Trauner, D.*; Broichhagen, J.*; Schaefer, M.*, ChemMedChem 2018, 13, 1028–1035.

24.A predictive approach for the optical control of carbonic anhydrase II activity, DuBay, K. H.; Iwan, K.; Osorio-Planes, L.; Geissler, P.; Groll, M.; Trauner, D.; Broichhagen, J.*, ACS Chem. Bio. 2018, 13, 793–800.

23.Conditional and reversible activation of class A and B G protein-coupled receptors using tethered pharmacology, Podewin, T.#; Ast, J.#; Broichhagen, J.#; Fine, N. H. F.; Nasteska, D.; Leippe, P.; Gailer, M.; Buenaventura, T.; Kanda, N.; Jones, B. J.; M’Kadmi, C.; Baneres, J.-L.; Marie, J.; Tomas, A.; Trauner, D.; Hoffmann-Röder, A.; Hodson, D. J., ACS Cent. Sci. 2018, 4, 166–179. 

22.Optical Control of a Biological Reaction-Diffusion System, Glock, P.; Broichhagen, J.; Kretschmer, S., Blumhardt, P.; Müksch, J.; Trauner, D.; Schwille, P., Angew. Chem. Int. Ed. 2018, 57, 2362–2366; Optical Control of a Biological Reaction-Diffusion System, Glock, P.; Broichhagen, J.; Kretschmer, S., Blumhardt, P.; Müksch, J.; Trauner, D.; Schwille, P., Angew. Chem. 2018, 130, 2386–2390.

21.Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor, Berry, H. M.; Holt, A.; Levitz, J.; Broichhagen, J.; Gaub, B. M.; Visel, M.; Stanley, C.; Kim, Y. J.; Cao, K.; Kramer, R. H.; Trauner, D.; Flannery, J.; Isacoff, E. Y., Nat. Commun. 2017, 8, 1862.

20. Optical control of GPR40 signalling in pancreatic β-cells, Frank, J.; Yushchenko, D.; Fine, N. H. F.; Duca, M.; Citir, M.; Broichhagen, J.; Hodson, D. J.; Schultz, C.; Trauner, D., Chem. Sci. 2017, 8, 7604–7610.

19.Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor, Jones, B. J.; Scopelliti, R.; Bloom, S. R.; Tomas, A.; Hodson, D. J.*; Broichhagen, J.*, ChemistryOpen 2017, 6, 501–505.

18.Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone, Podewin, T.#; Broichhagen, J.#; Frost, C.; Groneberg, D.; Ast, J.; Meyer-Berg, H.; Fine, N. H. F.; Friebe, A.; Zacharias, M.; Hodson, D. J.; Trauner, D.; Hoffmann-Röder, A., Chem. Sci. 2017, 8, 4644–4653.

17.Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors, Levitz, J.#; Broichhagen, J.#; Leippe, P.; Konrad, D.; Trauner, D.; Isacoff, E. Y., Proc. Natl. Acad. Sci. USA 2017, 114, E3546–E3554. 

16.Remote control of glucose homeostasis in vivo using photopharmacology, Mehta, Z. B.#; Johnston, N. R.#; Nguyen-Tu, M.-S.#; Broichhagen, J.; Schultz, P.; Larner, D. P.; Leclerc, I.; Trauner, D.; Rutter, G. A.; Hodson, D. J., Sci. Rep. 2017, 7, 291.

15.Beta cell hubs dictate pancreatic islet responses to glucose, Johnston, N. R.; Mitchell, R. K.; Haythorne, E.; Paiva Pessoa, M.-R., Semplici, F.; Ferrer, J.; Piemonti, L.; Marchetti, P.; Bugliani, M.; Bosco, D.; Berishvili, E.; Duncanson, P.; Watkinson, M.; Broichhagen, J.; Trauner, D.; Rutter, G. A.; Hodson, D. J., Cell Metab. 2016, 24, 1–13.

14.Allosteric Optical Control of a Class B G-Protein-Coupled Receptor, Broichhagen, J.; von Ohlen, Y.; Johnston, N. R.; Meyer-Berg, H.; Jones, B. J.; Bloom, S. R.; Rutter, G. A.; Trauner, D.; Hodson, D. J., Angew. Chem. Int. Ed. 2016, 55, 5865–5868; Allosterische optische Steuerung eines Klasse-B-G-Protein-gekoppelten Rezeptors, Broichhagen, J.; von Ohlen, Y.; Johnston, N. R.; Meyer-Berg, H.; Jones, B. J.; Bloom, S. R.; Rutter, G. A.; Trauner, D.; Hodson, D. J., Angew. Chem. 2016, 128, 5961–5965.

13.6-(6-(Pyridin-2-yl)-1,2,4,5-tetrazin-3-yl)pyridin-3-amine monohydrate, Broichhagen, J.; Klingl, Y. E.; Trauner, D.; Mayer, P., Acta Cryst. 2016, E72, 238–240.

12.Optical Control of Insulin Release Using an Incretin Switch, Broichhagen, J.#; Podewin, T.#; Meyer-Berg, H.; von Ohlen, Y.; Johnston, N. R.; Jones, B. J.; Bloom, S. R.; Rutter, G. A.; Hoffmann-Röder, A.; Hodson, D. J.; Trauner, D., Angew. Chem. Int. Ed. 2015, 54, 15565–15569; Optische Kontrolle der Insulinsekretion mit einem Inkretinschalter, Broichhagen, J.#; Podewin, T.#; Meyer-Berg, H.; von Ohlen, Y.; Johnston, N. R.; Jones, B. J.; Bloom, S. R.; Rutter, G. A.; Hoffmann-Röder, A.; Hodson, D. J.; Trauner, D., Angew. Chem. 2015, 127, 15786–15790.

11.Orthogonal optical control of a G protein-coupled receptor with a SNAP-tethered photochromic ligand, Broichhagen, J.#; Damijonaitis, A.#; Levitz, J.#; Sokol, K. R.; Leippe, P.; Konrad, D.; Isacoff, E. Y.; Trauner, D., ACS Cent. Sci. 2015, 1, 383–393. 

10. A roadmap to success in photopharmacology, Broichhagen, J.; Frank, J. A.; Trauner D., Acc. Chem. Res. 2015, 48, 1947–1960.

9.Azobenzene-based inhibitors of human carbonic anhydrase II, Runtsch, L. S.; Barber, D. M.; Mayer, P.; Groll, M.; Trauner, D.*; Broichhagen, J.*, Beilstein J. Org. Chem. 2015, 11, 1129–1135.

8.Crystal structure of (E)-1,2-bis(4-bromo-2,6-difluorophenyl)diazene, Broichhagen, J.; Woodmansee, D. H.; Trauner, D.; Mayer, P., Acta Cryst. 2015, E71, o459–o460.

7.A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function, Broichhagen, J.; Frank, J. A.; Johnston, N. R.; Mitchell, R. K.; Smid, K.; Marchetti, P.; Bugliani, M.; Rutter, G. A.; Trauner, D.; Hodson, D. J., Chem. Commun. 2015, 51, 6018–6021. 

6.AzoCholine enables optical control of alpha 7 nicotinic acetylcholine receptors in neural networks, Damijonaitis, A.; Broichhagen, J.; Hüll, K.; Nagpal, J.; Laprell, L.; Woodmansee, D. H.; Urushima, T.; Schönberger, M.; Rafiq, A.; Sumser, M. P.; Kummer, W.; Gottschalk, A.; Trauner, D., ACS Chem. Neurosci. 2015, 5, 701–707.

5. The in vivo chemistry of photochromic tethered ligands, Broichhagen, J.; Trauner, D., Curr. Opin. Chem. Biol. 2014, 21, 121–127.

4. Optical control of insulin release using a photoswitchable sulfonylurea, Broichhagen, J.; Schönberger, M.; Cork, S. C.; Frank, J. A.; Marchetti, P.; Bugliani, A. M.; Shapiro, A. M. J.; Trapp, S.; Rutter, G. A.; Hodson, D. J.; Trauner, D., Nat. Commun. 2014, 5, 5116.

3. Optical Control of Acetylcholinesterase with a Tacrine Switch, Broichhagen, J.; Jurastow, I.; Iwan, K.; Kummer, W.; Trauner, D., Angew. Chem. Int. Ed. 2014, 53, 7657-7660; Optische Kontrolle der Acetylcholinesterase mit einem schaltbaren Tacrin, Broichhagen, J.; Jurastow, I.; Iwan, K.; Kummer, W.; Trauner, D., Angew. Chem. 2014, 126, 7788–7792.

2.Bilirubin in a New Light, Broichhagen, J.; Trauner, D., Angew. Chem. Int. Ed. 2013, 52, 13868-13870; Bilirubin in einem neuen Licht, Broichhagen, J.; Trauner, D., Angew. Chem. 2013, 125, 14112–14114.

1.Strain-Promoted Alkyne Azide Cycloaddition for the Functionalization of Poly(amide)-Based Dendrons and Dendrimers, Ornelas, C.; Broichhagen, J.; Weck, M., J. Am. Chem. Soc. 2010, 132, 3923–3931.

# these authors contributed equally                      

* corresponding author

Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
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13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)
info(at)fmp-berlin.de

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