Current Research on PI-metabolizing enzymes

Further Contributions:

  • Lehmann, M., Lukonin, I., Noe, F., Schmoranzer, J., Clementi, C., Loerke, D., Haucke, V. (2019) Nanoscale coupling of endocytic pit growth and stability. Sci. Adv., 5, eaax5775.
  • Ebner, M., Koch, P.A., Haucke, V. (2019) Phosphoinositides in the control of lysosome function and homeostasis. Biochem. Soc. Trans., 47, 1173-1185.
  • Wang, H., Lo, W.T., Haucke, V. (2019) Phosphoinositide switches in endocytosis and in the endolysosomal system. Curr. Opin. Cell Biol., 59, 50-57.
  • Lo, W.T., Vujicic Zagar, A., Gerth, F., Lehmann, M., Puchkov, D., Krylova, O., Freund, C., Scapozza, L., Vadas, O., Haucke, V. (2017) A coincidence detection mechanism controls PX-BAR domain-mediated endocytic membrane remodeling via an allosteric structural switc. Dev. Cell, 43, 522-529.
  • Schöneberg, J., Lehmann, M., Ullrich, A., Posor, Y., Lo, W.T., Lichtner, G., Schmoranzer, J., Haucke, V., Noe, F. (2017) Lipid-mediated PX-BAR domain recruitment couples local membrane constriction  to endocytic vesicle fission. Nat. Commun., 8, 15873.
  • Ketel, K., Krauss, M., Nicot, A.S., Puchkov, D., Wieffer, M., Müller, R., Subramanian, D., Schultz, C., Laporte, J., Haucke, V. (2016) A phosphoinositide conversion mechanism for exit from endosomes. Nature, 529, 408-412.
  • Krauss, M., Haucke, V. (2016) Directing lipid transport at membrane contact sites. Nat. Cell Biol., 18, 461-3.
  • Marat, A.L., Haucke, V. (2016) Phosphatidylinositol 3-phosphates - at the interface between cell signalling and membrane traffic. EMBO J., 35, 561-579.
  • Haucke, V. (2015) Cell biology: On the endocytosis rollercoaster. Nature, 517, 446-447.
  • Reubold, T.F., Faelber, K., Plattner, N., Posor, Y., Ketel, K., Curth, U., Schlegel, J., Anand, R., Manstein, D.J., Noé, F., Haucke, V., Daumke, O., Eschenburg, S. (2015) Crystal structure of the dynamin tetramer. Nature, 525, 404-408.
  • Posor, Y., Eichhorn-Grünig, M., Haucke, V. (2015) Phosphoinositides in endocytosis. Biochim. Biophys. Acta, 1851, 794-804.
  • Daumke, O., Roux, A., Haucke, V. (2014) BAR domain scaffolds in dynamin-mediated membrane fission. Cell 156, 882-892.
  • Franco, I., Gulluni, F., Campa, C.C., Costa, C., Margaria, P., Ciraolo, E., Martini, M., Monteyne, D., De Luca, D., Germena, G.,  Posor, Y., Maffucci, T., Marengo, S., Haucke, V., Falasca, M., Perez-Morga, D., Boletta, A., Merlo, G.R.,  Hirsch, E. (2014) PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function. Dev. Cell, 28, 647-58.
  • Posor, Y., Eichhorn-Grünig, M., Puchkov, D., Schöneberg, J., Ullrich, A., Lampe, A., Müller, R., Zarbakhsh, Gulluni, F., Hirsch, E., Krauss, M., Schultz, C., Noe, F., Haucke, V. (2013) Spatiotemporal Control of Endocytosis by Phosphatidylinositol 3,4-Bisphosphate. Nature, 499, 233-237.
  • Wieffer, M., Cibrián Uhalte, E., Posor, Y., Otten, C., Branz, K., Schütz, I., Mössinger, J., Schu, P., Abdelilah-Seyfried, S., Krauß, M., Haucke, V. (2013) PI4K2/ AP-1-based TGN-endosomal sorting regulates Wnt signaling. Curr Biol., 23, 2185-90.
  • Puchkov, D. and Haucke, V. (2013) Greasing the synaptic vesicle cycle by membrane lipids. TrendsCell Biol., 23, 493–503.
  • Mössinger, J., Wieffer, M., Krause, E., Freund, C., Gerth, F., Krauss, M., Haucke, V. (2012) Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase ltch. EMBO Rep., 13, 1087-94.
  • Rao, Y., Ma, Q., Vahedi-Faridi, A., Sundborger, A., Pechstein, A., Puchkov, D., Luo, L., Shupliakov, O., Saenger, W., Haucke, V. (2010) Molecular basis for SH3-domain regulation of F-BAR-mediated membrane deformation. Proc. Natl. Acad. Sci. USA, 107, 8213-8218.
  • Kahlfeldt, N., Vahedi-Faridi, A., Schäfer, J.G., Krainer, G., Keller, S., Saenger, W., Krauss, M., Haucke V. (2010) Molecular basis for the association of PIPKIg-p90 with the clathrin adaptor AP-2, J. Biol. Chem., 285, 2734-2749.
  • Krauss, M. and Haucke, V. (2007) Phosphoinositide modifying enzymes at the interface between membrane traffic and cell signaling. EMBO Rep., 3, 241-246.
  • Krauss M., Kukhtina, V., Pechstein, A., and Haucke V. (2006) Stimulation of PIPK type I-mediated PI(4,5)P2 synthesis by endocytic AP-2mu adaptor cargo complexes. Proc. Natl. Acad. Sci. USA 103, 11934-9.

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