Department Physiology and Pathology of Ion Transport (Thomas J. Jentsch)

We continuously accept applications for postdoctoral and doctoral positions in the areas of Molecular Physiology, Biophysics (electrophysiology & ion imaging) and Cell Biology



Current opening in ERC- and DFG-funded projects (posted Dec 7, 2020)

Postdoc in Electrophysiology / Biophysics

We are looking for highly motivated candidates with previous hands-on experience in patch-clamp analysis, preferably in brain slices, but also of transfected cells, as well as very good knowledge of neurophysiology. Additional experienece in ion imaging and advanced data analysis would be an asset. The project(s) will involve the analysis of brain (and possibly other tissue) slices from various genetic mouse models for chloride transport generated in our lab, possibly combined with analysis of cells from primary cultures, or structure-function analysis of mutated channels and transporters in transfected cells. Our lab is fully equipped for electrophyisiology, including three slice patch-clamp setups equipped with camera systems for ion imaging. We offer highly innovative projects in a stimulating interdisciplinary environment with the possibility to expand the candidate's abilitities beyond electrophysiology. The educational background of successful candidates could be in biochemistry, biology, or physics.


Current opening in ERC- and DFG-funded projects (posted Dec 7, 2020)

Postdoc in Cell Biology / Molecular Physiology

We are looking for highly motivated postdoctoral researchers interested in unravelling exciting novel roles of anion transport in cellular and organismal function. After our molecular identification of novel anion channels, several of which also transport signaling molecules or localize to intracellular membranes, we dispose of several novel mouse models and other tools to discover new physiology and disease mechanisms in many different organs. A thorough background in cell biology and physiology is a prerequisite as is previous hands-on experience in standard techniques of molecular cell biology or morphology. Although the project may focus on a particular organ, the ideal candidate will be broadly interested in several areas of biology/physiology, such as neurobiology, nephrology, or immunology, as our research - depending on the transporter under study - may impact many different organs. Our lab is fully equipped for cell biology and morphology and is part of both the FMP and MDC with access to excellent facilities (e.g. advanced optical microscopy, EM, mass spec, screening unit etc). The educational background should be in natural sciences, including, but not limited to, biology, biochemistry, biophysics or medicine.


Please direct your applications with motivation letter, full CV and references to:
Prof. Thomas J. Jentsch, FMP/MDC, Phone: 0049 30 9406 2961


Short intro to our work

We are a highly interdisciplinary, international team working on diverse aspects of ion transport, with a focus on chloride channels and transporters, some of which (VRACs) also transport signaling molecules such as neurotransmitters and cGAMP. We have molecularly identified three 'novel' channel families and are investigating their function, with a strong interest in physiology and disease. We have discovered several human channelopathies which we are charaterizing using sophisticated genetic mouse models and a broad range of cell biological, biochemical, morphological and electrophysiological techniques. Since ion transport is crucial for may cellular and organismal processes, our research extends from neurobiology to many other areas such as endocrinology and blood pressure regulation, immunology and kidney pathophysiology. Besides studying the role of plasma membrane channels e.g. in excitability, a major focus is on ion transport in endosomes and lysosomes, their impact on intracellular trafficking and signaling and role in disease.
For more details see homepage of our group.

Recent publications include: Science 328: 1398 (2010); Science 328: 1401 (2010); Nature Neurosci 14: 763 (2011); Nature Neurosci 15: 138 (2012). EMBO J 31 : 1217 (2012) ; Nature Comm 5 : 3475 (2014) ; Science 344 : 634 (2014) ; EMBO J. 34 : 2993 (2015) ; J Cell Sci 130 : 1122 (2017) ; Nature Genet. 350 : 355 (2018) ; Nature Comm. 9 : 1974 (2018) ; eLife 8 : e49187 (2019) ; Nature Comm. 10 : 4678 (2019) ; EMBO J. 39 : e103358 (2020) ; Immunity 52 : 767 (2020) ; Am J. Hum. Genet. 107: 1062 (2020).



Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)

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