Contact

Prof. Dr. Michael Krauß
phone +49 30 94793 - 202 (office)
krauss(at)fmp-berlin.de

 

Michael Krauß Lab (Haucke Department)

Research Topics of the Krauß Group

Work in our lab focuses on the molecular mechanisms that underlie endocytic transport in both, neuronal and non-neuronal cells. Our studies aim at elucidating the functional interplay between

Small GTPases, for instance ADP ribosylation factors (Arf proteins)

Phosphoinositide-metabolizing enzymes triggering the generation of membrane subdomains dedicated to the formation of distinct transport vesicles, and

Adaptor proteins mediating the incorporation of select subsets of cargo proteins into newly forming transport vesicles.

By combining biochemical studies (including protein-protein and protein-lipid binding studies of native or of purified, recombinant components) with fluorescence-based microscopy techniques applied to cellular in vivo systems we were able to elaborate novel and important aspects about how cargo recognition, coat polymerization and membrane deformation are coordinated during the generation of transport carriers.

The formation of transport carriers on different subcellular membranes is coupled to the local generation of distinct species of phosphoinositides (PIs). PI(4,5)P2 (cyan) supports endocytic events at the plasma membrane, whereas PI(4)P (green) and PI(3)P (red) are predominantly synthesized during budding from Golgi membranes and from organelles of endosomal origin, respectively. Different PIs in turn facilitate membrane translocation of adaptor and accessory proteins, which are crucial for cargo recognition, membrane deformation and budding.

Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)
info(at)fmp-berlin.de

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