Dr. Katina Lazarow

Phone: +49 (0)30 9406 3072
Mail: lazarow(at)

What's new

Dharmacon Human Edit-R crRNA library targeting 647 Ubiquitination Enzymes now available for screening! [September 2016]

We are currently establishing CRISPR-Cas9 screening with arrayed synthetic crRNA libraries for high-throughput gene editing studies. [April 2016]

We have assembled our own Silencer® siRNA subsets targeting 838 human kinases and 312 human phosphatases. Now available for screening! [May 2015]

Selected publication

Voss et al., Science 2014:

Screening Unit

RNAi and CRISPR-Cas9 Screening

The facility offers scientists from the FMP and MDC access to high-throughput screening with arrayed miRNA, siRNA and crRNA libraries on the basis of a scientific collaboration.


Broad range of assays

State of the art equipment supports a broad range of assays in high-throughput formats, ranging from basic reporter assays to high-content screening campaigns. Instrumentation covers automated widefield microscopy, flow cytometry and real-time kinetic fluorescence reading (see Technologies).

Full support in high-throughput screening

We operate on the basis of a scientific collaboration and offer support through all stages of a screening campaign: assay development and adaption to high-throughput screening, the actual wet-lab screen, data acquisition and quality assessment, statistical analysis as well as hit candidate selection.

In the course of the wet-lab screen, every single microplate is assessed by multiple quality control metrics (e.g. SSMD, Z′-factor) and visualisations (e.g. plate heatmaps, scatter plots). After experimental data acquisition is completed, resulting data is processed and putative hit candidates are selected. Raw and processed data are handed out to the researcher, accompanied by a comprehensive report.

Data mining

We are constantly advancing our in-house analysis, database and reporting tools to keep the platform updated. The integration of freely available open-source tools (e.g. KNIME Analytics Platform) and the development of our own analysis workflows enables us to meet the specific requirements of a multitude of biological questions. We also update permanently the annotations of our probes from public databases to provide you with most actual data.

Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP)
Campus Berlin-Buch
Robert-Roessle-Str. 10
13125 Berlin, Germany
+4930 94793 - 100 
+4930 94793 - 109 (Fax)

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