Philipp Alexander Koch

Nutrient-regulated control of lysosome function by signaling lipid conversion

• Michael Ebner; Dmytro Puchkov; Orestes López-Ortega; Pathma Muthukottiappan; Yanwei Su; Christopher Schmied; Silke Zillmann; Iryna Nikonenko; Jochen Koddebusch; Gillian L. Dornan; Max T. Lucht; Vonda Koka; Wonyul Jang; Philipp Alexander Koch; Alexander Wallroth; Martin Lehmann; Britta Brügger; Mario Pende; Dominic Winter; Volker Haucke

Cell 2023

Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover.

• Posor Y; Kampyli C; Bilanges B; Ganguli S; Koch PA; Wallroth A; Morelli D; Jenkins M; Alliouachene S; Deltcheva E; Baum B; Haucke V; Vanhaesebroeck B

Developmental cell 2022

Antagonistic control of active surface integrins by myotubularin and phosphatidylinositol 3-kinase C2β in a myotubular myopathy model

• Paula Samsó; Philipp A. Koch; York Posor; Wen-Ting Lo; Hassane Belabed; Marc Nazare; Jocelyn Laporte; Volker Haucke

Proceedings of the National Academy of Sciences 2022

The molecular mechanisms mediating class II PI 3‐kinase function in cell physiology

• Philipp Alexander Koch; Gillian Leigh Dornan; Manuel Hessenberger; Volker Haucke

The FEBS Journal 2021

Genetic basis of neurodevelopmental disorders in 103 Jordanian families.

• Froukh T; Nafie O; Al Hait SAS; Laugwitz L; Sommerfeld J; Sturm M; Baraghiti A; Issa T; Al-Nazer A; Koch PA; Hanselmann J; Kootz B; Bauer P; Buchert R

Clinical genetics 2020

Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway.

• Wang H; Loerke D; Bruns C; Müller R; Koch PA; Puchkov D; Schultz C; Haucke V

The Journal of biological chemistry 2019

Phosphoinositides in the control of lysosome function and homeostasis.

• Ebner M; Koch PA; Haucke V

Biochemical Society transactions 2019

Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1.

• Wallroth A; Koch PA; Marat AL; Krause E; Haucke V

Nature cell biology 2019

Peptides in headlock--a novel high-affinity and versatile peptide-binding nanobody for proteomics and microscopy.

• Braun MB; Traenkle B; Koch PA; Emele F; Weiss F; Poetz O; Stehle T; Rothbauer U

Scientific reports 2016